SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rlf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 3rlf MALTOSE/MALTODEXTRIN
IMPORT ATP-BINDING
PROTEIN MALK
(Escherichia
coli) 		4 / 8 LEU A 242
SER A 282
PHE A 355
GLY A 359
 None
 0.92A 1fapB-3rlfA:
undetectable		 1fapB-3rlfA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2502_0
(FERROCHELATASE)		 3rlf MALTOSE/MALTODEXTRIN
IMPORT ATP-BINDING
PROTEIN MALK
(Escherichia
coli) 		4 / 8 MET A 198
ARG A 351
VAL A 371
GLY A 370
 None
 1.01A 1hrkB-3rlfA:
undetectable		 1hrkB-3rlfA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 3rlf MALTOSE/MALTODEXTRIN
IMPORT ATP-BINDING
PROTEIN MALK
(Escherichia
coli) 		5 / 10 ILE A  62
GLY A  63
GLU A  30
GLY A  29
GLU A  28
 None
 1.15A 1mehA-3rlfA:
undetectable		 1mehA-3rlfA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VIF_A_FOLA1_0
(DIHYDROFOLATE
REDUCTASE)		 3rlf MALTOSE/MALTODEXTRIN
IMPORT ATP-BINDING
PROTEIN MALK
(Escherichia
coli) 		3 / 3 GLN A 331
ILE A 316
TYR A 329
 None
 0.71A 1vifA-3rlfA:
undetectable		 1vifA-3rlfA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		 3rlf MALTOSE/MALTODEXTRIN
IMPORT ATP-BINDING
PROTEIN MALK
(Escherichia
coli) 		5 / 12 VAL A 266
LEU A 242
SER A 282
LEU A 258
LEU A 268
 None
 1.04A 1ya4C-3rlfA:
2.8		 1ya4C-3rlfA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_B_P1ZB2001_1
(SERUM ALBUMIN)		 3rlf MALTOSE TRANSPORT
SYSTEM PERMEASE
PROTEIN MALG
MALTOSE/MALTODEXTRIN
IMPORT ATP-BINDING
PROTEIN MALK
(Escherichia
coli) 		5 / 9 GLU G 189
LEU A  90
HIS A  89
ALA A  85
ALA G 192
 None
 1.30A 2bxcB-3rlfG:
undetectable		 2bxcB-3rlfG:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CC8_A_RBFA1067_1
(VNG1446H)		 3rlf MALTOSE TRANSPORT
SYSTEM PERMEASE
PROTEIN MALG
(Escherichia
coli) 		3 / 3 PHE G  79
VAL G 240
TRP G  84
 None
 0.81A 2cc8A-3rlfG:
undetectable		 2cc8A-3rlfG:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CCB_A_RBFA1067_1
(VNG1446H)		 3rlf MALTOSE TRANSPORT
SYSTEM PERMEASE
PROTEIN MALG
(Escherichia
coli) 		3 / 3 PHE G  79
VAL G 240
TRP G  84
 None
 0.82A 2ccbA-3rlfG:
undetectable		 2ccbA-3rlfG:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 3rlf MALTOSE TRANSPORT
SYSTEM PERMEASE
PROTEIN MALG
MALTOSE/MALTODEXTRIN
IMPORT ATP-BINDING
PROTEIN MALK
(Escherichia
coli) 		4 / 5 SER G 187
LEU A  86
GLY G 293
ARG A 146
 None
 1.17A 2j2pA-3rlfG:
undetectable
2j2pB-3rlfG:
undetectable		 2j2pA-3rlfG:
19.13
2j2pB-3rlfG:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VX9_A_RBFA1064_1
(DODECIN)		 3rlf MALTOSE TRANSPORT
SYSTEM PERMEASE
PROTEIN MALG
(Escherichia
coli) 		3 / 3 PHE G  79
VAL G 240
TRP G  84
 None
 0.81A 2vx9A-3rlfG:
undetectable		 2vx9A-3rlfG:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_2
(CYTOCHROME P450 2R1)		 3rlf MALTOSE/MALTODEXTRIN
IMPORT ATP-BINDING
PROTEIN MALK
(Escherichia
coli) 		3 / 3 MET A 260
VAL A 298
GLU A 257
 None
 0.59A 3c6gA-3rlfA:
undetectable		 3c6gA-3rlfA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_G_ACTG225_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3rlf MALTOSE/MALTODEXTRIN
IMPORT ATP-BINDING
PROTEIN MALK
(Escherichia
coli) 		3 / 3 PRO A 225
LEU A 221
GLN A 214
 None
 0.69A 3hznG-3rlfA:
undetectable
3hznH-3rlfA:
undetectable		 3hznG-3rlfA:
22.89
3hznH-3rlfA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_A_SALA301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 3rlf MALTOSE/MALTODEXTRIN
IMPORT ATP-BINDING
PROTEIN MALK
(Escherichia
coli) 		4 / 8 ARG A 286
VAL A 230
TYR A 222
GLN A 194
 None
 1.00A 3remA-3rlfA:
undetectable		 3remA-3rlfA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3REM_B_SALB301_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 3rlf MALTOSE/MALTODEXTRIN
IMPORT ATP-BINDING
PROTEIN MALK
(Escherichia
coli) 		4 / 8 ARG A 286
VAL A 230
TYR A 222
GLN A 194
 None
 1.00A 3remB-3rlfA:
undetectable		 3remB-3rlfA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TPX_E_ACTE204_0
(E3 UBIQUITIN-PROTEIN
LIGASE MDM2)		 3rlf MALTOSE/MALTODEXTRIN
IMPORT ATP-BINDING
PROTEIN MALK
(Escherichia
coli) 		3 / 3 LYS A 217
PRO A 218
LEU A 219
 None
 0.50A 3tpxE-3rlfA:
undetectable		 3tpxE-3rlfA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_2
(ADENOSINE KINASE)		 3rlf MALTOSE TRANSPORT
SYSTEM PERMEASE
PROTEIN MALG
(Escherichia
coli) 		4 / 4 LEU G 236
SER G 234
LEU G 137
LEU G 156
 None
 1.07A 4n09A-3rlfG:
undetectable		 4n09A-3rlfG:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_2
(ADENOSINE KINASE)		 3rlf MALTOSE TRANSPORT
SYSTEM PERMEASE
PROTEIN MALG
(Escherichia
coli) 		4 / 5 LEU G 236
SER G 234
LEU G 137
LEU G 156
 None
 1.07A 4n09B-3rlfG:
undetectable		 4n09B-3rlfG:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3rlf MALTOSE TRANSPORT
SYSTEM PERMEASE
PROTEIN MALG
(Escherichia
coli) 		4 / 5 GLY G 196
ASP G 195
GLU G 189
VAL G 294
 None
 1.07A 4nkvD-3rlfG:
undetectable		 4nkvD-3rlfG:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_2
(ANDROGEN RECEPTOR)		 3rlf MALTOSE TRANSPORT
SYSTEM PERMEASE
PROTEIN MALG
(Escherichia
coli) 		4 / 6 LEU G 156
ASN G 157
LEU G 235
VAL G 247
 None
 1.01A 4okbA-3rlfG:
undetectable		 4okbA-3rlfG:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6V_E_RBFE201_1
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E)		 3rlf MALTOSE/MALTODEXTRIN
IMPORT ATP-BINDING
PROTEIN MALK
(Escherichia
coli) 		4 / 5 HIS A 317
VAL A 307
GLU A 308
VAL A 328
 None
 1.27A 4p6vB-3rlfA:
undetectable
4p6vE-3rlfA:
undetectable		 4p6vB-3rlfA:
19.08
4p6vE-3rlfA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA845_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 3rlf MALTOSE TRANSPORT
SYSTEM PERMEASE
PROTEIN MALG
MALTOSE/MALTODEXTRIN
IMPORT ATP-BINDING
PROTEIN MALK
(Escherichia
coli) 		4 / 8 ARG A 146
ALA G 191
LEU G 194
GLY A  78
 None
 1.01A 4xk8a-3rlfA:
undetectable		 4xk8a-3rlfA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_1
(FK506-BINDING
PROTEIN 1)		 3rlf MALTOSE/MALTODEXTRIN
IMPORT ATP-BINDING
PROTEIN MALK
(Escherichia
coli) 		3 / 3 ILE A 320
PRO A 321
ILE A 323
 None
 0.34A 5hw8F-3rlfA:
undetectable		 5hw8F-3rlfA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZP_A_CFFA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 3rlf MALTOSE/MALTODEXTRIN
IMPORT ATP-BINDING
PROTEIN MALK
(Escherichia
coli) 		5 / 9 ILE A 345
VAL A 298
MET A 260
LEU A 242
ILE A 285
 None
 1.33A 5mzpA-3rlfA:
undetectable		 5mzpA-3rlfA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZP_A_CFFA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 3rlf MALTOSE/MALTODEXTRIN
IMPORT ATP-BINDING
PROTEIN MALK
(Escherichia
coli) 		5 / 9 ILE A 345
VAL A 298
MET A 260
LEU A 283
ILE A 285
 None
 1.10A 5mzpA-3rlfA:
undetectable		 5mzpA-3rlfA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB307_0
(WELO5)		 3rlf MALTOSE/MALTODEXTRIN
IMPORT ATP-BINDING
PROTEIN MALK
(Escherichia
coli) 		3 / 3 GLU A 339
HIS A 317
VAL A 307
 None
 0.91A 5trqB-3rlfA:
undetectable		 5trqB-3rlfA:
22.66