SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rm5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4003_1
(SERUM ALBUMIN)		 3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 372
VAL A 356
ALA A 475
LEU A 476
 None
 0.76A 1e7bB-3rm5A:
3.3		 1e7bB-3rm5A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCL_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
N-ACETYL-D-HIS-L-PRO
-OH)		 3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 445
GLU A 540
PHE A 372
TYR A 383
 None
 1.46A 1mclA-3rm5A:
undetectable
1mclB-3rm5A:
undetectable
1mclP-3rm5A:
undetectable		 1mclA-3rm5A:
18.18
1mclB-3rm5A:
18.18
1mclP-3rm5A:
0.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20
(Saccharomyces
cerevisiae) 		4 / 8 ALA A 248
TYR A 269
LEU A 245
GLY A 242
 None
None
None
SO4  A   1 (-3.3A)
 0.87A 1rukH-3rm5A:
undetectable
1rukL-3rm5A:
undetectable		 1rukH-3rm5A:
17.51
1rukL-3rm5A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 161
GLY A 200
LEU A 245
VAL A 263
ILE A 156
 None
 1.27A 1zq9A-3rm5A:
undetectable		 1zq9A-3rm5A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20
(Saccharomyces
cerevisiae) 		4 / 8 VAL A 410
TYR A 503
GLY A 510
ALA A 506
 None
 0.70A 2a1hA-3rm5A:
undetectable
2a1hB-3rm5A:
undetectable		 2a1hA-3rm5A:
20.63
2a1hB-3rm5A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_B_SCKB951_1
(ACETYLCHOLINESTERASE)		 3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 379
ASP A 376
TYR A 472
HIS A 353
 None
 1.41A 2ha2B-3rm5A:
undetectable		 2ha2B-3rm5A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH8_A_VIBA1_1
(MAJOR PRION PROTEIN)		 3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20
(Saccharomyces
cerevisiae) 		4 / 6 PRO A 467
HIS A 346
ASP A 348
TYR A 350
 None
 1.40A 2lh8A-3rm5A:
undetectable		 2lh8A-3rm5A:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_A_CLUA808_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20
(Saccharomyces
cerevisiae) 		4 / 7 ALA A 273
TYR A 269
TYR A 295
HIS A 293
 None
 1.44A 2pncA-3rm5A:
undetectable		 2pncA-3rm5A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 172
ASN A 195
THR A 191
 None
 0.77A 2q63A-3rm5A:
undetectable		 2q63A-3rm5A:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_C_CTCC1385_0
(TETX2 PROTEIN)		 3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 126
ASN A  62
GLN A  64
HIS A 239
GLY A  99
 SO4  A   1 (-2.8A)
None
None
None
None
 1.44A 2y6rC-3rm5A:
undetectable		 2y6rC-3rm5A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20
(Saccharomyces
cerevisiae) 		3 / 3 SER A  28
GLY A  99
GLY A  31
 None
 0.50A 3bogA-3rm5A:
undetectable
3bogC-3rm5A:
undetectable		 3bogA-3rm5A:
undetectable
3bogC-3rm5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20
(Saccharomyces
cerevisiae) 		3 / 3 SER A  28
GLY A  99
GLY A  39
 None
 0.53A 3bogA-3rm5A:
undetectable
3bogC-3rm5A:
undetectable		 3bogA-3rm5A:
undetectable
3bogC-3rm5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		 3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20
(Saccharomyces
cerevisiae) 		5 / 10 ILE A  29
ASN A  94
LEU A  84
ASN A  87
LEU A  88
 None
 1.15A 3o02A-3rm5A:
undetectable
3o02B-3rm5A:
undetectable		 3o02A-3rm5A:
19.53
3o02B-3rm5A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_C_ACHC323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 383
GLU A 540
TYR A 445
PHE A 543
 None
 0.95A 3rqwC-3rm5A:
3.5
3rqwD-3rm5A:
3.6		 3rqwC-3rm5A:
18.07
3rqwD-3rm5A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_I_ACHI323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 383
GLU A 540
TYR A 445
PHE A 543
 None
 0.95A 3rqwI-3rm5A:
undetectable
3rqwJ-3rm5A:
undetectable		 3rqwI-3rm5A:
18.07
3rqwJ-3rm5A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_J_ACHJ323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20
(Saccharomyces
cerevisiae) 		4 / 8 GLU A 540
TYR A 445
PHE A 543
TYR A 383
 None
 0.94A 3rqwF-3rm5A:
undetectable
3rqwJ-3rm5A:
undetectable		 3rqwF-3rm5A:
18.07
3rqwJ-3rm5A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_C_T1CC401_1
(TETX2 PROTEIN)		 3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20
(Saccharomyces
cerevisiae) 		5 / 11 ASP A 126
ASN A  62
GLN A  64
HIS A 239
GLY A  99
 SO4  A   1 (-2.8A)
None
None
None
None
 1.45A 3v3oC-3rm5A:
undetectable		 3v3oC-3rm5A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_A_P1BA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 513
LEU A 465
ILE A 406
PHE A 449
TYR A 379
 None
 1.23A 4a79A-3rm5A:
undetectable		 4a79A-3rm5A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A79_B_P1BB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 513
LEU A 465
ILE A 406
PHE A 449
TYR A 379
 None
 1.24A 4a79B-3rm5A:
undetectable		 4a79B-3rm5A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_A_RGZA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 513
LEU A 465
ILE A 406
PHE A 449
TYR A 379
 None
 1.19A 4a7aA-3rm5A:
undetectable		 4a7aA-3rm5A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_A_UEGA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20
(Saccharomyces
cerevisiae) 		5 / 11 ALA A  38
VAL A  69
VAL A 128
HIS A 239
CYH A 243
 None
None
SO4  A   1 (-3.5A)
None
None
 1.01A 4c5lA-3rm5A:
32.3		 4c5lA-3rm5A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_A_UEGA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20
(Saccharomyces
cerevisiae) 		8 / 11 GLY A  31
ASP A  33
ALA A  38
GLY A  39
MET A 100
VAL A 128
HIS A 239
CYH A 243
 None
None
None
None
None
SO4  A   1 (-3.5A)
None
None
 0.37A 4c5lA-3rm5A:
32.3		 4c5lA-3rm5A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20
(Saccharomyces
cerevisiae) 		5 / 9 ALA A  38
VAL A  69
VAL A 128
HIS A 239
CYH A 243
 None
None
SO4  A   1 (-3.5A)
None
None
 1.05A 4c5lB-3rm5A:
32.6		 4c5lB-3rm5A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20
(Saccharomyces
cerevisiae) 		8 / 9 GLY A  31
ASP A  33
ALA A  38
GLY A  39
MET A 100
VAL A 128
HIS A 239
CYH A 243
 None
None
None
None
None
SO4  A   1 (-3.5A)
None
None
 0.38A 4c5lB-3rm5A:
32.6		 4c5lB-3rm5A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20
(Saccharomyces
cerevisiae) 		5 / 10 ALA A  38
VAL A  69
VAL A 128
HIS A 239
CYH A 243
 None
None
SO4  A   1 (-3.5A)
None
None
 0.98A 4c5lC-3rm5A:
32.6		 4c5lC-3rm5A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20
(Saccharomyces
cerevisiae) 		8 / 10 GLY A  31
ASP A  33
ALA A  38
GLY A  39
MET A 100
VAL A 128
HIS A 239
CYH A 243
 None
None
None
None
None
SO4  A   1 (-3.5A)
None
None
 0.38A 4c5lC-3rm5A:
32.6		 4c5lC-3rm5A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20
(Saccharomyces
cerevisiae) 		5 / 10 ALA A  38
VAL A  69
VAL A 128
HIS A 239
CYH A 243
 None
None
SO4  A   1 (-3.5A)
None
None
 1.00A 4c5lD-3rm5A:
32.5		 4c5lD-3rm5A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20
(Saccharomyces
cerevisiae) 		8 / 10 GLY A  31
ASP A  33
ALA A  38
GLY A  39
MET A 100
VAL A 128
HIS A 239
CYH A 243
 None
None
None
None
None
SO4  A   1 (-3.5A)
None
None
 0.35A 4c5lD-3rm5A:
32.5		 4c5lD-3rm5A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_A_PXLA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20
(Saccharomyces
cerevisiae) 		6 / 7 GLY A  31
ASP A  33
GLY A  39
MET A 100
HIS A 239
CYH A 243
 None
 0.39A 4c5nA-3rm5A:
33.0		 4c5nA-3rm5A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20
(Saccharomyces
cerevisiae) 		5 / 10 ALA A  38
VAL A  69
VAL A 128
HIS A 239
CYH A 243
 None
None
SO4  A   1 (-3.5A)
None
None
 1.00A 4c5nB-3rm5A:
33.0		 4c5nB-3rm5A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20
(Saccharomyces
cerevisiae) 		8 / 10 GLY A  31
ASP A  33
ALA A  38
GLY A  39
MET A 100
VAL A 128
HIS A 239
CYH A 243
 None
None
None
None
None
SO4  A   1 (-3.5A)
None
None
 0.37A 4c5nB-3rm5A:
33.0		 4c5nB-3rm5A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_C_PXLC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20
(Saccharomyces
cerevisiae) 		7 / 8 GLY A  31
ASP A  33
GLY A  39
MET A 100
VAL A 128
HIS A 239
CYH A 243
 None
None
None
None
SO4  A   1 (-3.5A)
None
None
 0.41A 4c5nC-3rm5A:
32.8		 4c5nC-3rm5A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20
(Saccharomyces
cerevisiae) 		5 / 10 ALA A  38
VAL A  69
VAL A 128
HIS A 239
CYH A 243
 None
None
SO4  A   1 (-3.5A)
None
None
 1.00A 4c5nD-3rm5A:
33.1		 4c5nD-3rm5A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20
(Saccharomyces
cerevisiae) 		8 / 10 GLY A  31
ASP A  33
ALA A  38
GLY A  39
MET A 100
VAL A 128
HIS A 239
CYH A 243
 None
None
None
None
None
SO4  A   1 (-3.5A)
None
None
 0.47A 4c5nD-3rm5A:
33.1		 4c5nD-3rm5A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_D_GAID410_0
(PROTEIN (ARGINASE))		 3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20
(Saccharomyces
cerevisiae) 		4 / 6 ARG A 504
LEU A 469
MET A 507
ASP A 508
 None
 1.48A 4cevD-3rm5A:
3.1
4cevE-3rm5A:
3.5		 4cevD-3rm5A:
21.90
4cevE-3rm5A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_F_GAIF411_0
(PROTEIN (ARGINASE))		 3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20
(Saccharomyces
cerevisiae) 		4 / 6 ARG A 504
LEU A 469
MET A 507
ASP A 508
 None
 1.50A 4cevE-3rm5A:
3.1
4cevF-3rm5A:
3.6		 4cevE-3rm5A:
21.90
4cevF-3rm5A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20
(Saccharomyces
cerevisiae) 		4 / 8 GLN A 178
ILE A 227
VAL A 216
PHE A 225
 None
 0.98A 4dx7B-3rm5A:
2.1		 4dx7B-3rm5A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_1
(DIPEPTIDYL PEPTIDASE
4)		 3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 439
TYR A 472
VAL A 410
TYR A 379
HIS A 417
 None
 1.30A 4ffwB-3rm5A:
undetectable		 4ffwB-3rm5A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J14_A_X2NA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20
(Saccharomyces
cerevisiae) 		5 / 10 LEU A  27
ILE A  40
ALA A  30
THR A  59
ALA A 105
 None
 1.10A 4j14A-3rm5A:
undetectable		 4j14A-3rm5A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20
(Saccharomyces
cerevisiae) 		4 / 5 GLU A 540
TYR A 445
PHE A 543
TYR A 383
 None
 0.99A 4twdA-3rm5A:
3.3
4twdE-3rm5A:
3.3		 4twdA-3rm5A:
16.91
4twdE-3rm5A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_B_377B401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 383
GLU A 540
TYR A 445
PHE A 543
 None
 1.00A 4twdA-3rm5A:
3.3
4twdB-3rm5A:
0.0		 4twdA-3rm5A:
16.91
4twdB-3rm5A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20
(Saccharomyces
cerevisiae) 		4 / 6 TYR A 383
GLU A 540
TYR A 445
PHE A 543
 None
 1.04A 4twdB-3rm5A:
3.5
4twdC-3rm5A:
3.4		 4twdB-3rm5A:
16.91
4twdC-3rm5A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 383
GLU A 540
TYR A 445
PHE A 543
 None
 1.07A 4twdC-3rm5A:
3.4
4twdD-3rm5A:
3.6		 4twdC-3rm5A:
16.91
4twdD-3rm5A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20
(Saccharomyces
cerevisiae) 		4 / 6 TYR A 383
GLU A 540
TYR A 445
PHE A 543
 None
 1.05A 4twdD-3rm5A:
3.6
4twdE-3rm5A:
3.3		 4twdD-3rm5A:
16.91
4twdE-3rm5A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20
(Saccharomyces
cerevisiae) 		4 / 6 TYR A 383
GLU A 540
TYR A 445
PHE A 543
 None
 1.00A 4twdF-3rm5A:
1.4
4twdG-3rm5A:
0.7		 4twdF-3rm5A:
16.91
4twdG-3rm5A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20
(Saccharomyces
cerevisiae) 		4 / 6 TYR A 383
GLU A 540
TYR A 445
PHE A 543
 None
 1.06A 4twdG-3rm5A:
undetectable
4twdH-3rm5A:
undetectable		 4twdG-3rm5A:
16.91
4twdH-3rm5A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20
(Saccharomyces
cerevisiae) 		4 / 6 TYR A 383
GLU A 540
TYR A 445
PHE A 543
 None
 1.06A 4twdI-3rm5A:
undetectable
4twdJ-3rm5A:
undetectable		 4twdI-3rm5A:
16.91
4twdJ-3rm5A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP6_A_B40A601_1
(TRANSPORTER)		 3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20
(Saccharomyces
cerevisiae) 		4 / 5 ASP A  33
VAL A 128
ASP A 126
GLY A 242
 None
SO4  A   1 (-3.5A)
SO4  A   1 (-2.8A)
SO4  A   1 (-3.3A)
 0.98A 4xp6A-3rm5A:
undetectable		 4xp6A-3rm5A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 389
VAL A 386
SER A 453
PHE A 449
HIS A 516
 None
 1.11A 5ergB-3rm5A:
undetectable		 5ergB-3rm5A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HQA_A_ACRA705_2
(ALPHA-GLUCOSIDASE)		 3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20
(Saccharomyces
cerevisiae) 		4 / 8 TRP A 494
TRP A 502
HIS A 417
THR A 466
 None
 1.31A 5hqaA-3rm5A:
undetectable		 5hqaA-3rm5A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 372
LEU A 476
ASP A 376
ILE A 373
 None
 1.00A 5ik1A-3rm5A:
1.1		 5ik1A-3rm5A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_2
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 124
ARG A  51
PRO A  24
 None
 0.73A 5koxA-3rm5A:
undetectable		 5koxA-3rm5A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_2
(PROTEASE PR5-DRV)		 3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 242
VAL A 124
GLY A 266
ILE A 267
 SO4  A   1 (-3.3A)
None
None
None
 0.67A 5kr1B-3rm5A:
undetectable		 5kr1B-3rm5A:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20
(Saccharomyces
cerevisiae) 		5 / 12 THR A 281
THR A  65
GLN A  64
GLY A 289
THR A 236
 None
 1.31A 5l5zH-3rm5A:
undetectable
5l5zI-3rm5A:
undetectable		 5l5zH-3rm5A:
18.76
5l5zI-3rm5A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20
(Saccharomyces
cerevisiae) 		5 / 12 THR A 281
THR A  65
GLN A  64
GLY A 289
THR A 236
 None
 1.30A 5l5zV-3rm5A:
undetectable
5l5zW-3rm5A:
undetectable		 5l5zV-3rm5A:
18.76
5l5zW-3rm5A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OTR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3rm5 HYDROXYMETHYLPYRIMID
INE/PHOSPHOMETHYLPYR
IMIDINE KINASE THI20
(Saccharomyces
cerevisiae) 		4 / 5 VAL A 124
ASP A 126
PRO A 127
ALA A 246
 None
SO4  A   1 (-2.8A)
SO4  A   1 (-4.4A)
None
 1.08A 5otrA-3rm5A:
undetectable		 5otrA-3rm5A:
22.44