SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rmg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_2
(TRANSTHYRETIN)		 3rmg OCTAPRENYL-DIPHOSPHA
TE SYNTHASE
(Bacteroides
thetaiotaomicron) 		4 / 7 LEU A  52
ALA A 183
THR A  67
VAL A 187
 None
 0.90A 1dvxB-3rmgA:
undetectable		 1dvxB-3rmgA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_C_T44C128_1
(TRANSTHYRETIN)		 3rmg OCTAPRENYL-DIPHOSPHA
TE SYNTHASE
(Bacteroides
thetaiotaomicron) 		5 / 11 LEU A 272
ALA A 256
ALA A 243
LEU A 241
THR A 276
 None
 0.99A 1ictA-3rmgA:
undetectable
1ictC-3rmgA:
undetectable		 1ictA-3rmgA:
18.48
1ictC-3rmgA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_1
(PROTEASE)		 3rmg OCTAPRENYL-DIPHOSPHA
TE SYNTHASE
(Bacteroides
thetaiotaomicron) 		5 / 10 ASP A 212
ASP A 213
GLY A 205
ILE A 204
ILE A 289
 None
 0.96A 1muiA-3rmgA:
undetectable		 1muiA-3rmgA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_2
(PROTEASE)		 3rmg OCTAPRENYL-DIPHOSPHA
TE SYNTHASE
(Bacteroides
thetaiotaomicron) 		5 / 12 ASP A 212
ASP A 213
GLY A 205
ILE A 204
ILE A 289
 None
 0.89A 1muiB-3rmgA:
undetectable		 1muiB-3rmgA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_2
(PROTEASE)		 3rmg OCTAPRENYL-DIPHOSPHA
TE SYNTHASE
(Bacteroides
thetaiotaomicron) 		5 / 9 ASP A 212
ILE A 168
GLY A 205
ILE A 204
ILE A 289
 None
 1.07A 3ndwB-3rmgA:
undetectable		 3ndwB-3rmgA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_B_T44B128_1
(TRANSTHYRETIN)		 3rmg OCTAPRENYL-DIPHOSPHA
TE SYNTHASE
(Bacteroides
thetaiotaomicron) 		4 / 7 LEU A  52
ALA A 183
THR A  67
VAL A 187
 None
 0.93A 3ozkB-3rmgA:
undetectable		 3ozkB-3rmgA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_D_SALD404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 3rmg OCTAPRENYL-DIPHOSPHA
TE SYNTHASE
(Bacteroides
thetaiotaomicron) 		4 / 5 ALA A 285
PRO A 239
TYR A 242
ALA A 243
 None
 1.25A 3twpD-3rmgA:
undetectable		 3twpD-3rmgA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3rmg OCTAPRENYL-DIPHOSPHA
TE SYNTHASE
(Bacteroides
thetaiotaomicron) 		3 / 3 LYS A 258
GLU A 268
TRP A 251
 None
 1.49A 3v4tH-3rmgA:
undetectable		 3v4tH-3rmgA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		 3rmg OCTAPRENYL-DIPHOSPHA
TE SYNTHASE
(Bacteroides
thetaiotaomicron) 		4 / 7 LEU A  74
THR A 127
ALA A  70
THR A  67
 None
 0.94A 4d7bA-3rmgA:
undetectable		 4d7bA-3rmgA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_A_IMNA201_1
(TRANSTHYRETIN)		 3rmg OCTAPRENYL-DIPHOSPHA
TE SYNTHASE
(Bacteroides
thetaiotaomicron) 		4 / 7 LEU A  74
THR A 127
ALA A  70
THR A  67
 None
 0.87A 4ik7A-3rmgA:
undetectable		 4ik7A-3rmgA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTP_A_ASCA802_0
(RRNA N-GLYCOSIDASE)		 3rmg OCTAPRENYL-DIPHOSPHA
TE SYNTHASE
(Bacteroides
thetaiotaomicron) 		4 / 5 TYR A 292
ILE A 289
TYR A 164
ILE A 210
 None
 1.01A 4jtpA-3rmgA:
undetectable		 4jtpA-3rmgA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A202_1
(PROTEASE)		 3rmg OCTAPRENYL-DIPHOSPHA
TE SYNTHASE
(Bacteroides
thetaiotaomicron) 		5 / 10 ASP A 212
ASP A 213
GLY A 205
ILE A 204
ILE A 289
 None
 0.90A 4ll3A-3rmgA:
undetectable		 4ll3A-3rmgA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_A_RITA500_2
(PROTEASE)		 3rmg OCTAPRENYL-DIPHOSPHA
TE SYNTHASE
(Bacteroides
thetaiotaomicron) 		5 / 11 ASP A 212
ASP A 213
GLY A 205
ILE A 204
ILE A 289
 None
 0.93A 4njvB-3rmgA:
undetectable		 4njvB-3rmgA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD5_A_GEOA501_1
(NUPC FAMILY PROTEIN)		 3rmg OCTAPRENYL-DIPHOSPHA
TE SYNTHASE
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A 201
ALA A 180
VAL A  56
TYR A  60
LEU A 312
 None
 1.14A 4pd5A-3rmgA:
1.7		 4pd5A-3rmgA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_1
(NUPC FAMILY PROTEIN)		 3rmg OCTAPRENYL-DIPHOSPHA
TE SYNTHASE
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A 201
ALA A 180
VAL A  56
TYR A  60
LEU A 312
 None
 1.19A 4pd9A-3rmgA:
1.7		 4pd9A-3rmgA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_D_FK5D201_1
(FK506-BINDING
PROTEIN 1)		 3rmg OCTAPRENYL-DIPHOSPHA
TE SYNTHASE
(Bacteroides
thetaiotaomicron) 		5 / 11 TYR A 164
ASP A 213
PHE A 165
ILE A 214
ILE A 282
 None
 1.24A 5hw8D-3rmgA:
undetectable		 5hw8D-3rmgA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		 3rmg OCTAPRENYL-DIPHOSPHA
TE SYNTHASE
(Bacteroides
thetaiotaomicron) 		3 / 3 TYR A 284
TYR A 292
GLN A 291
 None
 1.11A 5jsdA-3rmgA:
undetectable
5jsdB-3rmgA:
undetectable		 5jsdA-3rmgA:
20.06
5jsdB-3rmgA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		 3rmg OCTAPRENYL-DIPHOSPHA
TE SYNTHASE
(Bacteroides
thetaiotaomicron) 		3 / 3 TYR A 284
TYR A 292
GLN A 291
 None
 1.11A 5jsdB-3rmgA:
undetectable
5jsdC-3rmgA:
undetectable		 5jsdB-3rmgA:
20.06
5jsdC-3rmgA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_1
(PROTEASE PR5-SQV)		 3rmg OCTAPRENYL-DIPHOSPHA
TE SYNTHASE
(Bacteroides
thetaiotaomicron) 		5 / 9 ASP A 212
ASP A 213
GLY A 205
ILE A 204
THR A 288
 None
 1.25A 5kr2A-3rmgA:
undetectable		 5kr2A-3rmgA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_1
(CYTOCHROME P450 2C9)		 3rmg OCTAPRENYL-DIPHOSPHA
TE SYNTHASE
(Bacteroides
thetaiotaomicron) 		5 / 12 ALA A  57
GLY A 201
ALA A 177
LEU A 139
LEU A 135
 None
 0.97A 5xxiA-3rmgA:
undetectable		 5xxiA-3rmgA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 3rmg OCTAPRENYL-DIPHOSPHA
TE SYNTHASE
(Bacteroides
thetaiotaomicron) 		5 / 10 VAL A  56
ALA A 183
LEU A 200
LEU A 316
LEU A 312
 None
 1.04A 6f6nA-3rmgA:
undetectable
6f6nB-3rmgA:
undetectable		 6f6nA-3rmgA:
15.21
6f6nB-3rmgA:
13.20