SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rmj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3rmj 2-ISOPROPYLMALATE
SYNTHASE
(Neisseria
meningitidis) 		6 / 12 ILE A 156
ALA A 159
TRP A 201
PHE A 140
ALA A 163
LEU A 189
 None
 1.27A 1fm6A-3rmjA:
undetectable		 1fm6A-3rmjA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3rmj 2-ISOPROPYLMALATE
SYNTHASE
(Neisseria
meningitidis) 		6 / 12 ILE A 156
ALA A 159
TRP A 201
PHE A 140
ALA A 163
LEU A 189
 None
 1.27A 1fm9A-3rmjA:
undetectable		 1fm9A-3rmjA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3rmj 2-ISOPROPYLMALATE
SYNTHASE
(Neisseria
meningitidis) 		6 / 12 ILE A 156
ALA A 159
TRP A 201
PHE A 140
ALA A 163
LEU A 189
 None
 1.31A 1k74A-3rmjA:
undetectable		 1k74A-3rmjA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 3rmj 2-ISOPROPYLMALATE
SYNTHASE
(Neisseria
meningitidis) 		4 / 8 ASP A 208
GLY A 210
ASP A  16
THR A 230
 None
None
MN  A 365 (-2.6A)
None
 0.87A 1m4iA-3rmjA:
undetectable		 1m4iA-3rmjA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3rmj 2-ISOPROPYLMALATE
SYNTHASE
(Neisseria
meningitidis) 		4 / 4 ALA A 241
VAL A 213
ALA A 212
HIS A 206
 None
None
None
MN  A 365 (-3.4A)
 1.25A 1q23F-3rmjA:
undetectable		 1q23F-3rmjA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3rmj 2-ISOPROPYLMALATE
SYNTHASE
(Neisseria
meningitidis) 		4 / 4 ALA A 241
VAL A 213
ALA A 212
HIS A 206
 None
None
None
MN  A 365 (-3.4A)
 1.18A 1q23K-3rmjA:
undetectable		 1q23K-3rmjA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 3rmj 2-ISOPROPYLMALATE
SYNTHASE
(Neisseria
meningitidis) 		4 / 8 THR A 265
GLY A 322
ILE A 268
VAL A 269
 None
 0.85A 1rxcB-3rmjA:
undetectable		 1rxcB-3rmjA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_E_URFE2031_1
(URIDINE
PHOSPHORYLASE)		 3rmj 2-ISOPROPYLMALATE
SYNTHASE
(Neisseria
meningitidis) 		4 / 8 THR A 265
GLY A 322
ILE A 268
VAL A 269
 None
 0.88A 1rxcE-3rmjA:
undetectable		 1rxcE-3rmjA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_I_URFI2041_1
(URIDINE
PHOSPHORYLASE)		 3rmj 2-ISOPROPYLMALATE
SYNTHASE
(Neisseria
meningitidis) 		4 / 8 THR A 265
GLY A 322
ILE A 268
VAL A 269
 None
 0.91A 1rxcI-3rmjA:
undetectable		 1rxcI-3rmjA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_K_URFK2061_1
(URIDINE
PHOSPHORYLASE)		 3rmj 2-ISOPROPYLMALATE
SYNTHASE
(Neisseria
meningitidis) 		4 / 8 THR A 265
GLY A 322
ILE A 268
VAL A 269
 None
 0.87A 1rxcK-3rmjA:
undetectable		 1rxcK-3rmjA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3rmj 2-ISOPROPYLMALATE
SYNTHASE
(Neisseria
meningitidis) 		6 / 12 ILE A 156
ALA A 159
TRP A 201
PHE A 140
ALA A 163
LEU A 189
 None
 1.32A 1xdkA-3rmjA:
undetectable		 1xdkA-3rmjA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_E_9CRE1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3rmj 2-ISOPROPYLMALATE
SYNTHASE
(Neisseria
meningitidis) 		6 / 12 ILE A 156
ALA A 159
TRP A 201
PHE A 140
ALA A 163
LEU A 189
 None
 1.32A 1xdkE-3rmjA:
undetectable		 1xdkE-3rmjA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_A_9CRA801_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3rmj 2-ISOPROPYLMALATE
SYNTHASE
(Neisseria
meningitidis) 		6 / 12 ILE A 156
ALA A 159
TRP A 201
PHE A 140
ALA A 163
LEU A 189
 None
 1.29A 1xlsA-3rmjA:
undetectable		 1xlsA-3rmjA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_B_9CRB802_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3rmj 2-ISOPROPYLMALATE
SYNTHASE
(Neisseria
meningitidis) 		6 / 12 ILE A 156
ALA A 159
TRP A 201
PHE A 140
ALA A 163
LEU A 189
 None
 1.28A 1xlsB-3rmjA:
undetectable		 1xlsB-3rmjA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_C_9CRC803_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3rmj 2-ISOPROPYLMALATE
SYNTHASE
(Neisseria
meningitidis) 		6 / 12 ILE A 156
ALA A 159
TRP A 201
PHE A 140
ALA A 163
LEU A 189
 None
 1.28A 1xlsC-3rmjA:
undetectable		 1xlsC-3rmjA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_D_9CRD804_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3rmj 2-ISOPROPYLMALATE
SYNTHASE
(Neisseria
meningitidis) 		6 / 12 ILE A 156
ALA A 159
TRP A 201
PHE A 140
ALA A 163
LEU A 189
 None
 1.29A 1xlsD-3rmjA:
undetectable		 1xlsD-3rmjA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 3rmj 2-ISOPROPYLMALATE
SYNTHASE
(Neisseria
meningitidis) 		5 / 12 HIS A 204
ARG A 225
LEU A 250
ILE A 246
SER A 216
 MN  A 365 (-3.4A)
None
None
None
None
 1.31A 2fj1A-3rmjA:
undetectable		 2fj1A-3rmjA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 3rmj 2-ISOPROPYLMALATE
SYNTHASE
(Neisseria
meningitidis) 		5 / 12 GLY A 164
ASP A 137
VAL A 138
ARG A  97
VAL A 125
 None
 1.09A 2qe6B-3rmjA:
undetectable		 2qe6B-3rmjA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		 3rmj 2-ISOPROPYLMALATE
SYNTHASE
(Neisseria
meningitidis) 		6 / 12 VAL A 247
ALA A 249
ALA A 288
VAL A 290
VAL A   7
THR A 261
 None
 1.45A 3czhA-3rmjA:
undetectable		 3czhA-3rmjA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3rmj 2-ISOPROPYLMALATE
SYNTHASE
(Neisseria
meningitidis) 		4 / 7 GLU A 244
VAL A 290
VAL A 321
TRP A 323
 None
 1.26A 3dqrA-3rmjA:
undetectable
3dqrB-3rmjA:
undetectable		 3dqrA-3rmjA:
22.35
3dqrB-3rmjA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 3rmj 2-ISOPROPYLMALATE
SYNTHASE
(Neisseria
meningitidis) 		4 / 5 ASP A  11
ILE A 246
VAL A   7
THR A 167
 None
 1.19A 3eigA-3rmjA:
undetectable		 3eigA-3rmjA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 3rmj 2-ISOPROPYLMALATE
SYNTHASE
(Neisseria
meningitidis) 		5 / 12 GLY A  48
GLU A  46
GLY A  87
ALA A  93
PHE A  57
 None
 1.24A 3qowA-3rmjA:
undetectable		 3qowA-3rmjA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOD_A_HQEA1173_1
(FMN-BINDING PROTEIN)		 3rmj 2-ISOPROPYLMALATE
SYNTHASE
(Neisseria
meningitidis) 		4 / 7 ASP A 144
ARG A 237
HIS A 206
HIS A 108
 None
None
MN  A 365 (-3.4A)
None
 1.40A 3zodA-3rmjA:
undetectable		 3zodA-3rmjA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZTV_A_ADNA1600_1
(NAD NUCLEOTIDASE)		 3rmj 2-ISOPROPYLMALATE
SYNTHASE
(Neisseria
meningitidis) 		5 / 9 ASN A 240
GLY A 235
GLY A 239
GLY A  17
ASP A  16
 MN  A 365 (-2.6A)
None
None
None
MN  A 365 (-2.6A)
 1.13A 3ztvA-3rmjA:
2.0		 3ztvA-3rmjA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3rmj 2-ISOPROPYLMALATE
SYNTHASE
(Neisseria
meningitidis) 		4 / 7 GLU A 244
VAL A 290
VAL A 321
TRP A 323
 None
 1.30A 4cx4A-3rmjA:
undetectable
4cx4B-3rmjA:
undetectable		 4cx4A-3rmjA:
22.35
4cx4B-3rmjA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_C_URFC1301_1
(URIDINE
PHOSPHORYLASE)		 3rmj 2-ISOPROPYLMALATE
SYNTHASE
(Neisseria
meningitidis) 		4 / 8 THR A 265
GLY A 322
ILE A 268
VAL A 269
 None
 0.87A 4e1vC-3rmjA:
undetectable		 4e1vC-3rmjA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_E_URFE1301_1
(URIDINE
PHOSPHORYLASE)		 3rmj 2-ISOPROPYLMALATE
SYNTHASE
(Neisseria
meningitidis) 		4 / 8 THR A 265
GLY A 322
ILE A 268
VAL A 269
 None
 0.86A 4e1vE-3rmjA:
undetectable		 4e1vE-3rmjA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H2F_A_ADNA601_1
(5'-NUCLEOTIDASE)		 3rmj 2-ISOPROPYLMALATE
SYNTHASE
(Neisseria
meningitidis) 		5 / 9 ASN A 240
GLY A 235
GLY A 239
GLY A  17
ASP A  16
 MN  A 365 (-2.6A)
None
None
None
MN  A 365 (-2.6A)
 1.12A 4h2fA-3rmjA:
2.3		 4h2fA-3rmjA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H2G_A_ADNA603_1
(5'-NUCLEOTIDASE)		 3rmj 2-ISOPROPYLMALATE
SYNTHASE
(Neisseria
meningitidis) 		5 / 9 ASN A 240
GLY A 235
GLY A 239
GLY A  17
ASP A  16
 MN  A 365 (-2.6A)
None
None
None
MN  A 365 (-2.6A)
 1.06A 4h2gA-3rmjA:
2.6		 4h2gA-3rmjA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3rmj 2-ISOPROPYLMALATE
SYNTHASE
(Neisseria
meningitidis) 		4 / 4 ASN A 240
GLY A  17
ASP A 137
ASP A  11
 MN  A 365 (-2.6A)
None
None
None
 1.32A 4n49A-3rmjA:
undetectable		 4n49A-3rmjA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB307_1
(CHITOSANASE)		 3rmj 2-ISOPROPYLMALATE
SYNTHASE
(Neisseria
meningitidis) 		4 / 7 THR A 230
GLY A  17
THR A  12
HIS A 206
 None
None
None
MN  A 365 (-3.4A)
 0.93A 4qwpB-3rmjA:
undetectable		 4qwpB-3rmjA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_D_READ602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 3rmj 2-ISOPROPYLMALATE
SYNTHASE
(Neisseria
meningitidis) 		5 / 12 GLU A 183
ARG A 187
TRP A 201
CYH A 142
LEU A 189
 None
 1.25A 5fhzD-3rmjA:
undetectable		 5fhzD-3rmjA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 3rmj 2-ISOPROPYLMALATE
SYNTHASE
(Neisseria
meningitidis) 		4 / 8 LEU A 259
LEU A 217
ILE A 170
TRP A 201
 None
 1.02A 5ljbA-3rmjA:
undetectable		 5ljbA-3rmjA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 3rmj 2-ISOPROPYLMALATE
SYNTHASE
(Neisseria
meningitidis) 		3 / 3 ARG A  81
PHE A  49
ARG A  77
 None
 1.16A 5y9yA-3rmjA:
undetectable		 5y9yA-3rmjA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3rmj 2-ISOPROPYLMALATE
SYNTHASE
(Neisseria
meningitidis) 		6 / 12 ILE A 156
ALA A 159
TRP A 201
PHE A 140
ALA A 163
LEU A 189
 None
 1.31A 5z12B-3rmjA:
undetectable		 5z12B-3rmjA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_C_9CRC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3rmj 2-ISOPROPYLMALATE
SYNTHASE
(Neisseria
meningitidis) 		6 / 12 ILE A 156
ALA A 159
TRP A 201
PHE A 140
ALA A 163
LEU A 189
 None
 1.26A 5z12C-3rmjA:
undetectable		 5z12C-3rmjA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3rmj 2-ISOPROPYLMALATE
SYNTHASE
(Neisseria
meningitidis) 		6 / 12 ILE A 156
ALA A 159
TRP A 201
PHE A 140
ALA A 163
LEU A 189
 None
 1.31A 6a5yD-3rmjA:
undetectable		 6a5yD-3rmjA:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3rmj 2-ISOPROPYLMALATE
SYNTHASE
(Neisseria
meningitidis) 		4 / 8 ASP A 172
HIS A  99
ASP A  16
GLU A 236
 None
GOL  A 367 ( 4.8A)
MN  A 365 (-2.6A)
None
 0.87A 6mn4A-3rmjA:
undetectable		 6mn4A-3rmjA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3rmj 2-ISOPROPYLMALATE
SYNTHASE
(Neisseria
meningitidis) 		4 / 8 ASP A 172
HIS A  99
ASP A  16
GLU A 236
 None
GOL  A 367 ( 4.8A)
MN  A 365 (-2.6A)
None
 0.87A 6mn4B-3rmjA:
undetectable		 6mn4B-3rmjA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3rmj 2-ISOPROPYLMALATE
SYNTHASE
(Neisseria
meningitidis) 		4 / 8 ASP A 172
HIS A  99
ASP A  16
GLU A 236
 None
GOL  A 367 ( 4.8A)
MN  A 365 (-2.6A)
None
 1.01A 6mn4D-3rmjA:
undetectable		 6mn4D-3rmjA:
21.22