SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rmu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)		 3rmu METHYLMALONYL-COA
EPIMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ALA A 153
GLY A 155
HIS A  82
LEU A  79
PRO A  78
 None
 1.32A 1cmcA-3rmuA:
undetectable
1cmcB-3rmuA:
undetectable		 1cmcA-3rmuA:
21.28
1cmcB-3rmuA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_1
(POL POLYPROTEIN)		 3rmu METHYLMALONYL-COA
EPIMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 ALA A  61
ILE A  53
GLY A 119
GLY A 118
PRO A 101
 None
 1.04A 1k6cA-3rmuA:
undetectable		 1k6cA-3rmuA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC2199_0
(PROTEIN (METHIONINE
REPRESSOR))		 3rmu METHYLMALONYL-COA
EPIMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ALA A 153
GLY A 155
HIS A  82
LEU A  79
PRO A  78
 None
 1.29A 1mj2C-3rmuA:
undetectable
1mj2D-3rmuA:
undetectable		 1mj2C-3rmuA:
21.28
1mj2D-3rmuA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 3rmu METHYLMALONYL-COA
EPIMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 170
VAL A 169
SER A 144
LEU A  45
LEU A  48
 None
None
None
EDO  A 177 ( 4.3A)
None
 1.26A 2zlcA-3rmuA:
undetectable		 2zlcA-3rmuA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_B_PNNB5002_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3rmu METHYLMALONYL-COA
EPIMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 5 ASN A 129
ALA A 132
ALA A 133
LYS A 140
 None
None
EDO  A 177 ( 3.9A)
EDO  A   2 ( 4.1A)
 1.03A 3kp2B-3rmuA:
undetectable		 3kp2B-3rmuA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 3rmu METHYLMALONYL-COA
EPIMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A  91
HIS A 154
LEU A  98
ILE A  53
ALA A  54
 None
 0.96A 3uwlB-3rmuA:
undetectable		 3uwlB-3rmuA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_D_FOZD316_0
(THYMIDYLATE SYNTHASE)		 3rmu METHYLMALONYL-COA
EPIMERASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A  91
HIS A 154
LEU A  98
ILE A  53
ALA A  54
 None
 0.97A 3uwlD-3rmuA:
undetectable		 3uwlD-3rmuA:
18.97