SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rnl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLB_A_NVPA999_1
(HIV-1 RT A-CHAIN)		 3rnl SULFOTRANSFERASE
(Alicyclobacillus
acidocaldarius) 		4 / 8 VAL A 161
TYR A 158
GLY A 162
LEU A 155
 None
None
None
GOL  A 313 (-3.9A)
 0.87A 1jlbA-3rnlA:
undetectable		 1jlbA-3rnlA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3rnl SULFOTRANSFERASE
(Alicyclobacillus
acidocaldarius) 		5 / 12 GLY A  17
ALA A  13
GLY A  12
LEU A 110
ILE A 183
 None
None
None
None
GOL  A 314 (-4.3A)
 0.99A 3ku1G-3rnlA:
undetectable		 3ku1G-3rnlA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 3rnl SULFOTRANSFERASE
(Alicyclobacillus
acidocaldarius) 		4 / 5 LEU A 163
GLY A 162
PHE A 280
PHE A 279
 None
 0.76A 3smtA-3rnlA:
undetectable		 3smtA-3rnlA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3rnl SULFOTRANSFERASE
(Alicyclobacillus
acidocaldarius) 		4 / 6 GLU A  85
TYR A  90
VAL A 174
PHE A   9
 None
 1.01A 4a97E-3rnlA:
undetectable		 4a97E-3rnlA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3rnl SULFOTRANSFERASE
(Alicyclobacillus
acidocaldarius) 		4 / 7 GLU A  85
TYR A  90
VAL A 174
PHE A   9
 None
 1.04A 4a97H-3rnlA:
undetectable		 4a97H-3rnlA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3rnl SULFOTRANSFERASE
(Alicyclobacillus
acidocaldarius) 		4 / 6 LEU A 155
TYR A 152
LEU A 127
GLU A 133
 GOL  A 313 (-3.9A)
None
None
None
 1.18A 4f3tA-3rnlA:
4.3		 4f3tA-3rnlA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUF_A_ACTA605_0
(SERUM ALBUMIN)		 3rnl SULFOTRANSFERASE
(Alicyclobacillus
acidocaldarius) 		4 / 4 ALA A  14
HIS A  40
PHE A  89
LEU A  91
 GOL  A 313 ( 4.0A)
None
GOL  A 313 (-4.9A)
None
 1.09A 4lufA-3rnlA:
0.0		 4lufA-3rnlA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUH_A_ACTA609_0
(SERUM ALBUMIN)		 3rnl SULFOTRANSFERASE
(Alicyclobacillus
acidocaldarius) 		4 / 4 ALA A  14
HIS A  40
PHE A  89
LEU A  91
 GOL  A 313 ( 4.0A)
None
GOL  A 313 (-4.9A)
None
 1.15A 4luhA-3rnlA:
undetectable		 4luhA-3rnlA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3rnl SULFOTRANSFERASE
(Alicyclobacillus
acidocaldarius) 		5 / 11 LEU A 272
ARG A 273
LEU A 276
LEU A 141
GLU A 133
 None
 1.11A 4wg0F-3rnlA:
undetectable
4wg0G-3rnlA:
undetectable
4wg0H-3rnlA:
undetectable		 4wg0F-3rnlA:
5.08
4wg0G-3rnlA:
5.08
4wg0H-3rnlA:
5.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 3rnl SULFOTRANSFERASE
(Alicyclobacillus
acidocaldarius) 		4 / 5 LEU A 155
TYR A 152
LEU A 127
GLU A 133
 GOL  A 313 (-3.9A)
None
None
None
 1.32A 5weaA-3rnlA:
3.9		 5weaA-3rnlA:
16.88