SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rnr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3rnr STAGE II SPORULATION
E FAMILY PROTEIN
(Thermanaerovibri
o
acidaminovorans) 		4 / 5 GLY A 135
ILE A 136
VAL A  47
SER A 132
 None
 1.20A 1rs7A-3rnrA:
undetectable		 1rs7A-3rnrA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_D_SALD1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3rnr STAGE II SPORULATION
E FAMILY PROTEIN
(Thermanaerovibri
o
acidaminovorans) 		5 / 12 THR A  67
GLY A  68
PHE A 133
GLY A  65
LEU A  64
 None
 1.10A 2y7kD-3rnrA:
undetectable		 2y7kD-3rnrA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 3rnr STAGE II SPORULATION
E FAMILY PROTEIN
(Thermanaerovibri
o
acidaminovorans) 		4 / 7 ASN A 138
ILE A 136
PHE A 133
GLN A  51
 None
None
None
ACY  A 213 ( 4.5A)
 1.28A 3tvxB-3rnrA:
undetectable		 3tvxB-3rnrA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3rnr STAGE II SPORULATION
E FAMILY PROTEIN
(Thermanaerovibri
o
acidaminovorans) 		5 / 12 ALA A 174
THR A 202
ALA A 176
VAL A   1
ALA A 183
 None
 1.44A 4df3B-3rnrA:
undetectable		 4df3B-3rnrA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA206_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 3rnr STAGE II SPORULATION
E FAMILY PROTEIN
(Thermanaerovibri
o
acidaminovorans) 		4 / 4 ALA A  46
ALA A  49
ALA A  50
ALA A  53
 None
 0.10A 4oadA-3rnrA:
undetectable		 4oadA-3rnrA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA208_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 3rnr STAGE II SPORULATION
E FAMILY PROTEIN
(Thermanaerovibri
o
acidaminovorans) 		4 / 4 ALA A  46
ALA A  49
ALA A  50
ALA A  53
 None
 0.11A 4oaeA-3rnrA:
undetectable		 4oaeA-3rnrA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1Y_D_LOCD502_2
(TUBULIN BETA CHAIN)		 3rnr STAGE II SPORULATION
E FAMILY PROTEIN
(Thermanaerovibri
o
acidaminovorans) 		5 / 12 LEU A  37
THR A 202
ALA A 204
VAL A 206
ALA A 176
 None
 0.79A 4x1yD-3rnrA:
undetectable		 4x1yD-3rnrA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 3rnr STAGE II SPORULATION
E FAMILY PROTEIN
(Thermanaerovibri
o
acidaminovorans) 		4 / 8 ARG A 103
ASP A 162
ASP A  90
ASP A 107
 None
None
GOL  A 212 (-2.7A)
None
 0.95A 4xqgA-3rnrA:
undetectable		 4xqgA-3rnrA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 3rnr STAGE II SPORULATION
E FAMILY PROTEIN
(Thermanaerovibri
o
acidaminovorans) 		4 / 8 ARG A 103
ASP A 162
ASP A  90
ASP A 107
 None
None
GOL  A 212 (-2.7A)
None
 0.96A 4xqgB-3rnrA:
undetectable		 4xqgB-3rnrA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_A_SAMA1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 3rnr STAGE II SPORULATION
E FAMILY PROTEIN
(Thermanaerovibri
o
acidaminovorans) 		4 / 4 SER A 105
SER A  87
GLU A 141
ASP A 107
 None
 1.35A 4ymgA-3rnrA:
undetectable		 4ymgA-3rnrA:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HSW_A_ACTA501_0
(ORF 37)		 3rnr STAGE II SPORULATION
E FAMILY PROTEIN
(Thermanaerovibri
o
acidaminovorans) 		4 / 5 SER A 105
SER A 143
SER A  87
SER A 145
 None
 1.45A 5hswA-3rnrA:
undetectable		 5hswA-3rnrA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_1
(REGULATORY PROTEIN
TETR)		 3rnr STAGE II SPORULATION
E FAMILY PROTEIN
(Thermanaerovibri
o
acidaminovorans) 		4 / 8 ILE A  63
GLN A  60
VAL A  54
ASP A  23
 None
 1.03A 5vlmF-3rnrA:
undetectable		 5vlmF-3rnrA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_1
(REGULATORY PROTEIN
TETR)		 3rnr STAGE II SPORULATION
E FAMILY PROTEIN
(Thermanaerovibri
o
acidaminovorans) 		4 / 8 GLY A  68
ILE A  63
GLN A  60
ASP A  23
 None
 0.80A 5vlmH-3rnrA:
undetectable		 5vlmH-3rnrA:
24.34