SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rns'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_0
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 3rns CUPIN 2 CONSERVED
BARREL DOMAIN
PROTEIN
(Leptotrichia
buccalis) 		5 / 12 ARG A  56
TYR A  57
GLY A 104
ILE A 103
LEU A 128
 None
 1.21A 1kglA-3rnsA:
undetectable		 1kglA-3rnsA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)		 3rns CUPIN 2 CONSERVED
BARREL DOMAIN
PROTEIN
(Leptotrichia
buccalis) 		4 / 8 TYR A  58
ILE A  67
LEU A  98
LEU A  41
 None
 0.86A 2w98B-3rnsA:
undetectable		 2w98B-3rnsA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3rns CUPIN 2 CONSERVED
BARREL DOMAIN
PROTEIN
(Leptotrichia
buccalis) 		5 / 12 VAL A  23
ALA A  42
LEU A  41
ARG A  14
LEU A  38
 None
 0.74A 3mb5A-3rnsA:
undetectable		 3mb5A-3rnsA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_A_XRAA233_2
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3rns CUPIN 2 CONSERVED
BARREL DOMAIN
PROTEIN
(Leptotrichia
buccalis) 		4 / 5 VAL A 151
PHE A  81
ILE A 154
PHE A 126
 None
 0.90A 3owxB-3rnsA:
undetectable		 3owxB-3rnsA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_0
(REGULATORY PROTEIN
TETR)		 3rns CUPIN 2 CONSERVED
BARREL DOMAIN
PROTEIN
(Leptotrichia
buccalis) 		5 / 12 ALA A 146
LEU A 219
ILE A 220
TYR A  59
PHE A  81
 None
 1.31A 5vlmB-3rnsA:
undetectable		 5vlmB-3rnsA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BER_A_DVAA2_0
(E(DVA)DP(DGL)(DHI)(D
PR)N(DAL)(DPR))		 3rns CUPIN 2 CONSERVED
BARREL DOMAIN
PROTEIN
(Leptotrichia
buccalis) 		3 / 3 GLU A 209
ASP A 164
PRO A 165
 None
 0.71A 6berA-3rnsA:
undetectable		 6berA-3rnsA:
5.45