SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ro2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_C_CCSC47_0
(GLUTATHIONE
S-TRANSFERASE)		 3ro2 G-PROTEIN-SIGNALING
MODULATOR 2
(Mus
musculus) 		4 / 6 THR A 204
LEU A 201
GLY A 199
TYR A 178
 None
 1.13A 1gtiC-3ro2A:
1.4		 1gtiC-3ro2A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 3ro2 G-PROTEIN-SIGNALING
MODULATOR 2
PEPTIDE OF NUCLEAR
MITOTIC APPARATUS
PROTEIN 1
(Mus
musculus;
Homo
sapiens) 		4 / 5 ILE A 224
ARG A 221
ASP B2005
ASN B2008
 None
 1.29A 1kiaD-3ro2A:
undetectable		 1kiaD-3ro2A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1867_0
(FPRA)		 3ro2 G-PROTEIN-SIGNALING
MODULATOR 2
(Mus
musculus) 		4 / 4 ALA A 303
ARG A 271
GLN A 306
GLU A 307
 None
 1.28A 1lqtB-3ro2A:
undetectable		 1lqtB-3ro2A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1424_0
(FPRA)		 3ro2 G-PROTEIN-SIGNALING
MODULATOR 2
(Mus
musculus) 		4 / 4 ALA A 303
ARG A 271
GLN A 306
GLU A 307
 None
 1.29A 1lquB-3ro2A:
undetectable		 1lquB-3ro2A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)		 3ro2 G-PROTEIN-SIGNALING
MODULATOR 2
PEPTIDE OF NUCLEAR
MITOTIC APPARATUS
PROTEIN 1
(Mus
musculus;
Homo
sapiens) 		3 / 3 ARG A 221
ASP B2005
ASN B2008
 None
 0.89A 1nbhA-3ro2A:
undetectable		 1nbhA-3ro2A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 3ro2 G-PROTEIN-SIGNALING
MODULATOR 2
PEPTIDE OF NUCLEAR
MITOTIC APPARATUS
PROTEIN 1
(Mus
musculus;
Homo
sapiens) 		3 / 3 ARG A 221
ASP B2005
ASN B2008
 None
 0.89A 1nbhD-3ro2A:
undetectable		 1nbhD-3ro2A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_1
(GLYCINE
N-METHYLTRANSFERASE)		 3ro2 G-PROTEIN-SIGNALING
MODULATOR 2
PEPTIDE OF NUCLEAR
MITOTIC APPARATUS
PROTEIN 1
(Mus
musculus;
Homo
sapiens) 		4 / 4 ILE A 224
ARG A 221
ASP B2005
ASN B2008
 None
 1.23A 1nbiC-3ro2A:
undetectable		 1nbiC-3ro2A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 3ro2 G-PROTEIN-SIGNALING
MODULATOR 2
PEPTIDE OF NUCLEAR
MITOTIC APPARATUS
PROTEIN 1
(Mus
musculus;
Homo
sapiens) 		4 / 4 ILE A 224
ARG A 221
ASP B2005
ASN B2008
 None
 1.24A 1nbiD-3ro2A:
undetectable		 1nbiD-3ro2A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_B_LOCB700_2
(TUBULIN BETA-2B
CHAIN)		 3ro2 G-PROTEIN-SIGNALING
MODULATOR 2
(Mus
musculus) 		5 / 11 LEU A 248
LEU A 241
ALA A 244
ASN A 203
ALA A 217
 None
 1.27A 3e22B-3ro2A:
undetectable		 3e22B-3ro2A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E22_D_LOCD700_2
(TUBULIN BETA-2B
CHAIN)		 3ro2 G-PROTEIN-SIGNALING
MODULATOR 2
(Mus
musculus) 		5 / 11 LEU A 248
LEU A 241
ALA A 244
ASN A 203
ALA A 217
 None
 1.26A 3e22D-3ro2A:
undetectable		 3e22D-3ro2A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 3ro2 G-PROTEIN-SIGNALING
MODULATOR 2
(Mus
musculus) 		4 / 6 GLY A 202
THR A 204
LEU A 208
ASP A 213
 None
 1.03A 3ps9A-3ro2A:
undetectable		 3ps9A-3ro2A:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_D_ACTD502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3ro2 G-PROTEIN-SIGNALING
MODULATOR 2
(Mus
musculus) 		3 / 3 GLY A 102
THR A 104
ASN A 100
 None
None
GOL  A   2 (-3.6A)
 0.72A 3v4tD-3ro2A:
0.2		 3v4tD-3ro2A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_A_NCAA1536_0
(DIPHTHERIA TOXIN)		 3ro2 G-PROTEIN-SIGNALING
MODULATOR 2
(Mus
musculus) 		4 / 6 GLY A 242
ALA A 244
TYR A 245
GLU A 219
 None
 0.99A 4ae1A-3ro2A:
2.6		 4ae1A-3ro2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA8_C_Z80C301_1
(MAJOR PRION PROTEIN)		 3ro2 G-PROTEIN-SIGNALING
MODULATOR 2
(Mus
musculus) 		4 / 5 LEU A 177
GLY A 142
ILE A 115
GLN A 119
 None
None
None
GOL  A   1 (-3.4A)
 1.15A 4ma8C-3ro2A:
undetectable		 4ma8C-3ro2A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA301_1
(CHITOSANASE)		 3ro2 G-PROTEIN-SIGNALING
MODULATOR 2
(Mus
musculus) 		3 / 3 TYR A 206
GLY A 156
PRO A 157
 None
 0.66A 4qwpA-3ro2A:
0.9		 4qwpA-3ro2A:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 3ro2 G-PROTEIN-SIGNALING
MODULATOR 2
PEPTIDE OF NUCLEAR
MITOTIC APPARATUS
PROTEIN 1
(Mus
musculus;
Homo
sapiens) 		5 / 11 ASN A  63
LEU B2004
LEU A 101
GLY A 102
ALA A  74
 GOL  A   2 (-3.6A)
GOL  A   2 ( 4.3A)
None
None
None
 1.36A 5fctA-3ro2A:
undetectable		 5fctA-3ro2A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3ro2 G-PROTEIN-SIGNALING
MODULATOR 2
(Mus
musculus) 		3 / 3 ALA A  97
ASN A 100
LEU A 101
 None
GOL  A   2 (-3.6A)
None
 0.40A 5i1oC-3ro2A:
undetectable		 5i1oC-3ro2A:
7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3ro2 G-PROTEIN-SIGNALING
MODULATOR 2
(Mus
musculus) 		3 / 3 ALA A  97
ASN A 100
LEU A 101
 None
GOL  A   2 (-3.6A)
None
 0.46A 5i1pD-3ro2A:
undetectable		 5i1pD-3ro2A:
7.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD15_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)		 3ro2 G-PROTEIN-SIGNALING
MODULATOR 2
(Mus
musculus) 		3 / 3 GLY A  31
CYH A  33
CYH A  28
 None
 0.97A 5inzB-3ro2A:
undetectable		 5inzB-3ro2A:
4.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD15_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)		 3ro2 G-PROTEIN-SIGNALING
MODULATOR 2
(Mus
musculus) 		3 / 3 GLY A  36
CYH A  28
CYH A  33
 None
 0.90A 5inzB-3ro2A:
undetectable		 5inzB-3ro2A:
4.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_2
(SCRFP-TAG,GP41)		 3ro2 G-PROTEIN-SIGNALING
MODULATOR 2
(Mus
musculus) 		4 / 7 LEU A  68
ASP A  70
ALA A  72
LEU A  75
 None
 0.93A 5nwvA-3ro2A:
undetectable		 5nwvA-3ro2A:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZSF_A_6T0A910_0
(TOLL-LIKE RECEPTOR 7)		 3ro2 G-PROTEIN-SIGNALING
MODULATOR 2
PEPTIDE OF NUCLEAR
MITOTIC APPARATUS
PROTEIN 1
(Mus
musculus;
Homo
sapiens) 		4 / 7 THR A 286
ILE A 246
TYR A 279
PHE B1992
 None
 0.95A 5zsfA-3ro2A:
undetectable
5zsfB-3ro2A:
undetectable		 5zsfA-3ro2A:
12.46
5zsfB-3ro2A:
12.46