SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ro3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_B_ADNB1301_1
(SUGAR KINASE MJ0406)		 3ro3 G-PROTEIN-SIGNALING
MODULATOR 2
(Mus
musculus) 		5 / 7 HIS A 205
ALA A 217
GLY A 199
GLY A 202
ASN A 203
 None
 1.36A 2c49B-3ro3A:
undetectable		 2c49B-3ro3A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_A_NCAA1536_0
(DIPHTHERIA TOXIN)		 3ro3 G-PROTEIN-SIGNALING
MODULATOR 2
(Mus
musculus) 		4 / 6 GLY A 242
ALA A 244
TYR A 245
GLU A 219
 None
 0.96A 4ae1A-3ro3A:
undetectable		 4ae1A-3ro3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 3ro3 G-PROTEIN-SIGNALING
MODULATOR 2
PEPTIDE OF PROTEIN
INSCUTEABLE HOMOLOG
(Mus
musculus;
Mus
musculus) 		5 / 11 ASN A 243
LEU B  77
LEU A 281
GLY A 282
ALA A 254
 None
 1.32A 5fctA-3ro3A:
undetectable		 5fctA-3ro3A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AN0_A_HISA520_0
(HISTIDINOL
DEHYDROGENASE)		 3ro3 G-PROTEIN-SIGNALING
MODULATOR 2
(Mus
musculus) 		4 / 6 LYS A 231
ARG A 235
GLU A 234
ALA A 237
 None
 1.03A 6an0A-3ro3A:
undetectable		 6an0A-3ro3A:
16.93