SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ro8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_F_CCSF47_0
(GLUTATHIONE
S-TRANSFERASE)		 3ro8 ENDO-1,4-BETA-XYLANA
SE
(Paenibacillus
sp.
JDR-2) 		4 / 5 THR A 266
LEU A 284
GLY A 280
TYR A 285
 None
 1.37A 1gtiF-3ro8A:
undetectable		 1gtiF-3ro8A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3003_1
(SERUM ALBUMIN)		 3ro8 ENDO-1,4-BETA-XYLANA
SE
(Paenibacillus
sp.
JDR-2) 		3 / 4 LYS A 201
ALA A 204
MET A 140
 None
 1.06A 1hk3A-3ro8A:
undetectable		 1hk3A-3ro8A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3ro8 ENDO-1,4-BETA-XYLANA
SE
(Paenibacillus
sp.
JDR-2) 		5 / 10 GLY A 228
VAL A 229
GLY A 230
MET A 231
VAL A 256
 None
 1.02A 1pwyE-3ro8A:
undetectable		 1pwyE-3ro8A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3ro8 ENDO-1,4-BETA-XYLANA
SE
(Paenibacillus
sp.
JDR-2) 		5 / 10 GLY A 228
VAL A 229
GLY A 230
MET A 231
VAL A 256
 None
 1.09A 1v3qE-3ro8A:
undetectable		 1v3qE-3ro8A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_F_CSCF1383_2
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 3ro8 ENDO-1,4-BETA-XYLANA
SE
(Paenibacillus
sp.
JDR-2) 		3 / 3 LEU A  33
MET A  36
MET A  78
 None
 0.94A 2vavF-3ro8A:
undetectable		 2vavF-3ro8A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 3ro8 ENDO-1,4-BETA-XYLANA
SE
(Paenibacillus
sp.
JDR-2) 		5 / 12 SER A 261
HIS A  79
TYR A 191
VAL A 256
GLY A 228
 None
 1.41A 3f8wB-3ro8A:
undetectable		 3f8wB-3ro8A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 3ro8 ENDO-1,4-BETA-XYLANA
SE
(Paenibacillus
sp.
JDR-2) 		4 / 6 GLY A  28
THR A  29
LEU A  33
ASP A  25
 None
 0.95A 3ps9A-3ro8A:
undetectable		 3ps9A-3ro8A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		 3ro8 ENDO-1,4-BETA-XYLANA
SE
(Paenibacillus
sp.
JDR-2) 		5 / 11 ILE A 119
ILE A 226
ALA A 174
GLU A 169
VAL A  84
 None
 1.11A 3tmzA-3ro8A:
undetectable		 3tmzA-3ro8A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)		 3ro8 ENDO-1,4-BETA-XYLANA
SE
(Paenibacillus
sp.
JDR-2) 		5 / 12 GLN A 170
ALA A 171
ALA A 174
ALA A 175
VAL A 122
 None
 1.11A 4j6dA-3ro8A:
undetectable		 4j6dA-3ro8A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 3ro8 ENDO-1,4-BETA-XYLANA
SE
(Paenibacillus
sp.
JDR-2) 		5 / 12 GLN A 170
ALA A 171
ALA A 174
ALA A 175
VAL A 122
 None
 1.12A 4j6dB-3ro8A:
undetectable		 4j6dB-3ro8A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_A_ASDA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 3ro8 ENDO-1,4-BETA-XYLANA
SE
(Paenibacillus
sp.
JDR-2) 		5 / 12 GLN A 170
ALA A 171
ALA A 174
ALA A 175
VAL A 122
 None
 1.12A 4jbtA-3ro8A:
undetectable		 4jbtA-3ro8A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_B_ASDB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 3ro8 ENDO-1,4-BETA-XYLANA
SE
(Paenibacillus
sp.
JDR-2) 		5 / 11 GLN A 170
ALA A 171
ALA A 174
ALA A 175
VAL A 122
 None
 1.13A 4jbtB-3ro8A:
undetectable		 4jbtB-3ro8A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3ro8 ENDO-1,4-BETA-XYLANA
SE
(Paenibacillus
sp.
JDR-2) 		5 / 12 HIS A 118
THR A 121
LEU A  93
GLY A  57
PHE A  61
 None
 1.35A 4pfjB-3ro8A:
undetectable		 4pfjB-3ro8A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD202_0
(RETINOL-BINDING
PROTEIN 2)		 3ro8 ENDO-1,4-BETA-XYLANA
SE
(Paenibacillus
sp.
JDR-2) 		4 / 5 ASP A 134
VAL A  82
TRP A  85
GLU A 138
 None
 1.48A 4qzuA-3ro8A:
0.0
4qzuD-3ro8A:
0.0		 4qzuA-3ro8A:
17.77
4qzuD-3ro8A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 3ro8 ENDO-1,4-BETA-XYLANA
SE
(Paenibacillus
sp.
JDR-2) 		6 / 12 VAL A 209
ILE A 205
ALA A 204
LYS A 201
VAL A 229
GLY A 228
 None
 1.20A 5j2tC-3ro8A:
undetectable		 5j2tC-3ro8A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_O_ASCO1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 3ro8 ENDO-1,4-BETA-XYLANA
SE
(Paenibacillus
sp.
JDR-2) 		4 / 7 HIS A 298
ILE A 299
VAL A 258
TYR A 190
 None
 1.23A 5kkzM-3ro8A:
undetectable
5kkzO-3ro8A:
undetectable		 5kkzM-3ro8A:
19.65
5kkzO-3ro8A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7B_B_PA1B204_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)		 3ro8 ENDO-1,4-BETA-XYLANA
SE
(Paenibacillus
sp.
JDR-2) 		3 / 3 GLY A 230
ASN A 192
ARG A 301
 None
 0.77A 5w7bD-3ro8A:
undetectable		 5w7bD-3ro8A:
11.31