SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rom'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ISM_A_NCAA303_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 3rom ADP-RIBOSYL CYCLASE
1
(Homo
sapiens) 		6 / 9 TRP A 125
LEU A 145
ASP A 155
TRP A 189
SER A 193
GLU A 226
 48Z  A 301 (-3.6A)
48Z  A 301 ( 4.8A)
None
None
48Z  A 301 (-2.8A)
48Z  A 301 (-2.0A)
 0.62A 1ismA-3romA:
28.3		 1ismA-3romA:
34.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 3rom ADP-RIBOSYL CYCLASE
1
(Homo
sapiens) 		4 / 7 TRP A 125
LEU A 145
ASP A 155
TRP A 189
 48Z  A 301 (-3.6A)
48Z  A 301 ( 4.8A)
None
None
 0.34A 1ismB-3romA:
28.4		 1ismB-3romA:
34.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1R15_C_NCAC439_0
(ADP-RIBOSYL CYCLASE)		 3rom ADP-RIBOSYL CYCLASE
1
(Homo
sapiens) 		3 / 3 TRP A 159
PHE A 188
TRP A 189
 None
 0.34A 1r15C-3romA:
25.3		 1r15C-3romA:
33.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1R15_F_NCAF469_0
(ADP-RIBOSYL CYCLASE)		 3rom ADP-RIBOSYL CYCLASE
1
(Homo
sapiens) 		3 / 3 TRP A 159
PHE A 188
TRP A 189
 None
 0.32A 1r15F-3romA:
25.2		 1r15F-3romA:
33.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1R15_G_NCAG479_0
(ADP-RIBOSYL CYCLASE)		 3rom ADP-RIBOSYL CYCLASE
1
(Homo
sapiens) 		3 / 3 TRP A 159
PHE A 188
TRP A 189
 None
 0.34A 1r15G-3romA:
25.3		 1r15G-3romA:
33.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1R15_H_NCAH489_0
(ADP-RIBOSYL CYCLASE)		 3rom ADP-RIBOSYL CYCLASE
1
(Homo
sapiens) 		3 / 3 TRP A 159
PHE A 188
TRP A 189
 None
 0.34A 1r15H-3romA:
25.2		 1r15H-3romA:
33.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA8_0
(GRAMICIDIN D)		 3rom ADP-RIBOSYL CYCLASE
1
(Homo
sapiens) 		3 / 3 VAL A 187
TRP A 189
VAL A 192
 None
 0.95A 2izqA-3romA:
undetectable
2izqB-3romA:
undetectable		 2izqA-3romA:
6.11
2izqB-3romA:
6.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 3rom ADP-RIBOSYL CYCLASE
1
(Homo
sapiens) 		4 / 6 THR A 148
THR A 144
ASN A 120
ASP A 202
 None
 1.29A 2okcA-3romA:
undetectable		 2okcA-3romA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_B_LDPB502_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 3rom ADP-RIBOSYL CYCLASE
1
(Homo
sapiens) 		4 / 5 GLN A 139
PHE A 135
PHE A 284
TRP A 241
 None
 1.41A 2qmzA-3romA:
5.3
2qmzB-3romA:
5.3		 2qmzA-3romA:
21.32
2qmzB-3romA:
21.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DZG_A_NCAA302_0
(ADP-RIBOSYL CYCLASE
1)		 3rom ADP-RIBOSYL CYCLASE
1
(Homo
sapiens) 		7 / 7 TRP A 125
LYS A 129
LEU A 145
GLU A 146
ASP A 155
TRP A 189
SER A 193
 48Z  A 301 (-3.6A)
None
48Z  A 301 ( 4.8A)
48Z  A 301 ( 4.3A)
None
None
48Z  A 301 (-2.8A)
 0.60A 3dzgA-3romA:
38.6		 3dzgA-3romA:
99.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DZG_B_NCAB302_0
(ADP-RIBOSYL CYCLASE
1)		 3rom ADP-RIBOSYL CYCLASE
1
(Homo
sapiens) 		7 / 7 TRP A 125
LEU A 145
GLU A 146
ASP A 155
TRP A 189
SER A 193
THR A 221
 48Z  A 301 (-3.6A)
48Z  A 301 ( 4.8A)
48Z  A 301 ( 4.3A)
None
None
48Z  A 301 (-2.8A)
48Z  A 301 (-4.0A)
 0.45A 3dzgB-3romA:
38.8		 3dzgB-3romA:
99.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)		 3rom ADP-RIBOSYL CYCLASE
1
(Homo
sapiens) 		4 / 6 LEU A 145
GLU A 146
TRP A 189
SER A 193
 48Z  A 301 ( 4.8A)
48Z  A 301 ( 4.3A)
None
48Z  A 301 (-2.8A)
 0.44A 3i9jB-3romA:
24.8		 3i9jB-3romA:
33.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ROP_A_NCAA302_0
(ADP-RIBOSYL CYCLASE
1)		 3rom ADP-RIBOSYL CYCLASE
1
(Homo
sapiens) 		6 / 6 TRP A 125
LEU A 145
GLU A 146
TRP A 189
SER A 193
THR A 221
 48Z  A 301 (-3.6A)
48Z  A 301 ( 4.8A)
48Z  A 301 ( 4.3A)
None
48Z  A 301 (-2.8A)
48Z  A 301 (-4.0A)
 0.54A 3ropA-3romA:
38.6		 3ropA-3romA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ROP_B_NCAB302_0
(ADP-RIBOSYL CYCLASE
1)		 3rom ADP-RIBOSYL CYCLASE
1
(Homo
sapiens) 		4 / 4 TRP A 125
GLU A 146
TRP A 189
THR A 221
 48Z  A 301 (-3.6A)
48Z  A 301 ( 4.3A)
None
48Z  A 301 (-4.0A)
 0.54A 3ropB-3romA:
38.8		 3ropB-3romA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_1
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 3rom ADP-RIBOSYL CYCLASE
1
(Homo
sapiens) 		5 / 12 VAL A  85
GLN A 115
THR A 116
VAL A 117
TYR A  70
 None
 1.49A 4s0vA-3romA:
undetectable		 4s0vA-3romA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMH_A_EF2A151_1
(CEREBLON ISOFORM 4)		 3rom ADP-RIBOSYL CYCLASE
1
(Homo
sapiens) 		4 / 7 ASN A 183
PRO A 184
PHE A  93
TRP A  50
 None
 1.36A 5amhA-3romA:
undetectable		 5amhA-3romA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 3rom ADP-RIBOSYL CYCLASE
1
(Homo
sapiens) 		4 / 7 GLY A 245
GLY A 210
ASP A 282
ASP A 249
 None
 0.76A 5ergB-3romA:
undetectable		 5ergB-3romA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_2
(CYTOCHROME P450 2C9)		 3rom ADP-RIBOSYL CYCLASE
1
(Homo
sapiens) 		4 / 4 PHE A 273
LEU A 123
LEU A 208
VAL A 204
 None
 1.06A 5xxiA-3romA:
undetectable		 5xxiA-3romA:
19.52