SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rot'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3rot ABC SUGAR
TRANSPORTER,
PERIPLASMIC SUGAR
BINDING PROTEIN
(Legionella
pneumophila) 		4 / 8 GLY A 163
THR A  87
THR A 113
ILE A 162
 None
None
GOL  A 317 ( 4.8A)
None
 0.74A 1c9sU-3rotA:
undetectable
1c9sV-3rotA:
undetectable		 1c9sU-3rotA:
13.47
1c9sV-3rotA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3rot ABC SUGAR
TRANSPORTER,
PERIPLASMIC SUGAR
BINDING PROTEIN
(Legionella
pneumophila) 		4 / 7 VAL A 108
GLY A  83
THR A  79
ILE A 106
 None
 0.85A 1gtnC-3rotA:
undetectable
1gtnD-3rotA:
undetectable		 1gtnC-3rotA:
13.47
1gtnD-3rotA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3rot ABC SUGAR
TRANSPORTER,
PERIPLASMIC SUGAR
BINDING PROTEIN
(Legionella
pneumophila) 		4 / 6 GLY A 163
THR A  87
THR A 113
ILE A 162
 None
None
GOL  A 317 ( 4.8A)
None
 0.77A 1gtnD-3rotA:
undetectable
1gtnE-3rotA:
undetectable		 1gtnD-3rotA:
13.47
1gtnE-3rotA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3rot ABC SUGAR
TRANSPORTER,
PERIPLASMIC SUGAR
BINDING PROTEIN
(Legionella
pneumophila) 		4 / 7 GLY A 163
THR A  87
THR A 113
ILE A 162
 None
None
GOL  A 317 ( 4.8A)
None
 0.73A 1gtnJ-3rotA:
undetectable
1gtnK-3rotA:
undetectable		 1gtnJ-3rotA:
13.47
1gtnK-3rotA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3rot ABC SUGAR
TRANSPORTER,
PERIPLASMIC SUGAR
BINDING PROTEIN
(Legionella
pneumophila) 		4 / 8 GLY A 163
THR A  87
THR A 113
ILE A 162
 None
None
GOL  A 317 ( 4.8A)
None
 0.66A 1gtnP-3rotA:
undetectable
1gtnQ-3rotA:
undetectable		 1gtnP-3rotA:
13.47
1gtnQ-3rotA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_A_ESTA1_1
(ESTROGEN RECEPTOR)		 3rot ABC SUGAR
TRANSPORTER,
PERIPLASMIC SUGAR
BINDING PROTEIN
(Legionella
pneumophila) 		5 / 10 LEU A 124
ALA A 110
LEU A 277
ILE A 106
LEU A  98
 None
 1.25A 1pcgA-3rotA:
undetectable		 1pcgA-3rotA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_B_TRPB81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rot ABC SUGAR
TRANSPORTER,
PERIPLASMIC SUGAR
BINDING PROTEIN
(Legionella
pneumophila) 		4 / 8 GLY A 163
THR A  87
THR A 113
ILE A 162
 None
None
GOL  A 317 ( 4.8A)
None
 0.77A 1utdB-3rotA:
undetectable
1utdC-3rotA:
undetectable		 1utdB-3rotA:
13.47
1utdC-3rotA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_F_TRPF81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rot ABC SUGAR
TRANSPORTER,
PERIPLASMIC SUGAR
BINDING PROTEIN
(Legionella
pneumophila) 		4 / 8 GLY A 163
THR A  87
THR A 113
ILE A 162
 None
None
GOL  A 317 ( 4.8A)
None
 0.77A 1utdF-3rotA:
undetectable
1utdG-3rotA:
undetectable		 1utdF-3rotA:
13.47
1utdG-3rotA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_J_TRPJ81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3rot ABC SUGAR
TRANSPORTER,
PERIPLASMIC SUGAR
BINDING PROTEIN
(Legionella
pneumophila) 		4 / 8 GLY A 163
THR A  87
THR A 113
ILE A 162
 None
None
GOL  A 317 ( 4.8A)
None
 0.77A 1utdJ-3rotA:
undetectable
1utdK-3rotA:
undetectable		 1utdJ-3rotA:
13.47
1utdK-3rotA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_C_CHDC3_0
(LIVER
CARBOXYLESTERASE 1)		 3rot ABC SUGAR
TRANSPORTER,
PERIPLASMIC SUGAR
BINDING PROTEIN
(Legionella
pneumophila) 		4 / 6 LEU A 227
LEU A 252
PRO A 238
VAL A 240
 None
 1.21A 2dqyC-3rotA:
2.3		 2dqyC-3rotA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EZ7_A_DHIA301_0
(CARBONIC ANHYDRASE 2)		 3rot ABC SUGAR
TRANSPORTER,
PERIPLASMIC SUGAR
BINDING PROTEIN
(Legionella
pneumophila) 		4 / 6 HIS A 161
GLN A  69
THR A 113
PRO A 115
 GOL  A 317 (-4.0A)
None
GOL  A 317 ( 4.8A)
None
 1.23A 2ez7A-3rotA:
undetectable		 2ez7A-3rotA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_A_SAMA301_0
(UPF0217 PROTEIN
AF_1056)		 3rot ABC SUGAR
TRANSPORTER,
PERIPLASMIC SUGAR
BINDING PROTEIN
(Legionella
pneumophila) 		5 / 9 LEU A 138
GLU A 140
ILE A 171
GLY A 170
LEU A 143
 None
 1.19A 2qmmA-3rotA:
2.0		 2qmmA-3rotA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3rot ABC SUGAR
TRANSPORTER,
PERIPLASMIC SUGAR
BINDING PROTEIN
(Legionella
pneumophila) 		3 / 3 ASN A 209
MET A 225
PHE A 202
 None
 1.07A 3g4lD-3rotA:
undetectable		 3g4lD-3rotA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3rot ABC SUGAR
TRANSPORTER,
PERIPLASMIC SUGAR
BINDING PROTEIN
(Legionella
pneumophila) 		5 / 6 VAL A 108
LEU A 285
MET A 280
ILE A  88
ILE A  84
 None
 1.48A 3gcsA-3rotA:
undetectable		 3gcsA-3rotA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3rot ABC SUGAR
TRANSPORTER,
PERIPLASMIC SUGAR
BINDING PROTEIN
(Legionella
pneumophila) 		4 / 5 GLY A 160
ILE A 162
VAL A  66
SER A  90
 None
 1.22A 4d33A-3rotA:
undetectable		 4d33A-3rotA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3rot ABC SUGAR
TRANSPORTER,
PERIPLASMIC SUGAR
BINDING PROTEIN
(Legionella
pneumophila) 		4 / 5 GLY A 160
ILE A 162
VAL A  66
SER A  90
 None
 1.27A 4d33B-3rotA:
undetectable		 4d33B-3rotA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3rot ABC SUGAR
TRANSPORTER,
PERIPLASMIC SUGAR
BINDING PROTEIN
(Legionella
pneumophila) 		3 / 3 ASN A 131
ASP A 112
ASP A  34
 None
GOL  A 317 (-2.8A)
None
 0.83A 4obwD-3rotA:
3.4		 4obwD-3rotA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 3rot ABC SUGAR
TRANSPORTER,
PERIPLASMIC SUGAR
BINDING PROTEIN
(Legionella
pneumophila) 		5 / 12 TYR A  36
SER A  39
TRP A  37
THR A 113
THR A  87
 GOL  A 317 (-3.9A)
None
None
GOL  A 317 ( 4.8A)
None
 1.24A 4u15A-3rotA:
undetectable		 4u15A-3rotA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 3rot ABC SUGAR
TRANSPORTER,
PERIPLASMIC SUGAR
BINDING PROTEIN
(Legionella
pneumophila) 		5 / 12 TYR A  36
SER A  39
TRP A  37
THR A 113
THR A  87
 GOL  A 317 (-3.9A)
None
None
GOL  A 317 ( 4.8A)
None
 1.29A 5dsgA-3rotA:
undetectable		 5dsgA-3rotA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 3rot ABC SUGAR
TRANSPORTER,
PERIPLASMIC SUGAR
BINDING PROTEIN
(Legionella
pneumophila) 		5 / 12 TYR A  36
SER A  39
TRP A  37
THR A 113
THR A  87
 GOL  A 317 (-3.9A)
None
None
GOL  A 317 ( 4.8A)
None
 1.31A 5dsgB-3rotA:
undetectable		 5dsgB-3rotA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 3rot ABC SUGAR
TRANSPORTER,
PERIPLASMIC SUGAR
BINDING PROTEIN
(Legionella
pneumophila) 		4 / 6 ILE A  73
ALA A  76
LEU A  77
ILE A 106
 None
 0.79A 5mvmB-3rotA:
undetectable
5mvmC-3rotA:
undetectable		 5mvmB-3rotA:
17.47
5mvmC-3rotA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6M_B_SALB503_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 3rot ABC SUGAR
TRANSPORTER,
PERIPLASMIC SUGAR
BINDING PROTEIN
(Legionella
pneumophila) 		4 / 7 THR A  87
HIS A  30
GLN A 158
THR A 215
 None
GOL  A 317 (-4.3A)
None
GOL  A 317 ( 4.7A)
 1.27A 5u6mB-3rotA:
4.4		 5u6mB-3rotA:
22.25