SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rp2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 3rp2 RAT MAST CELL
PROTEASE II
(Rattus
rattus) 		4 / 8 HIS A  57
SER A 195
VAL A 213
GLY A 216
 None
 0.52A 1aq7A-3rp2A:
35.0		 1aq7A-3rp2A:
35.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 3rp2 RAT MAST CELL
PROTEASE II
(Rattus
rattus) 		4 / 8 PHE A 228
THR A 229
ASP A 102
HIS A  57
 None
 0.86A 1ei6C-3rp2A:
undetectable		 1ei6C-3rp2A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_D_SAMD300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3rp2 RAT MAST CELL
PROTEASE II
(Rattus
rattus) 		6 / 12 GLY A 142
GLY A  44
GLY A 196
GLY A 193
THR A  54
LEU A  53
 None
 1.42A 2oxtD-3rp2A:
undetectable		 2oxtD-3rp2A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		 3rp2 RAT MAST CELL
PROTEASE II
(Rattus
rattus) 		3 / 3 LEU A  46
ARG A  49
ILE A  47
 None
 0.61A 2xn5B-3rp2A:
undetectable		 2xn5B-3rp2A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)		 3rp2 RAT MAST CELL
PROTEASE II
(Rattus
rattus) 		4 / 8 GLY A 184
ILE A  16
PHE A  45
PHE A 228
 None
 1.04A 3ko0B-3rp2A:
undetectable
3ko0J-3rp2A:
undetectable		 3ko0B-3rp2A:
21.89
3ko0J-3rp2A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJQ_A_27RA401_1
(DNA POLYMERASE III
SUBUNIT BETA)		 3rp2 RAT MAST CELL
PROTEASE II
(Rattus
rattus) 		4 / 5 ARG A  27
TYR A  29
PRO A 198
VAL A 213
 None
 1.49A 4mjqA-3rp2A:
undetectable		 4mjqA-3rp2A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_0
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 3rp2 RAT MAST CELL
PROTEASE II
(Rattus
rattus) 		5 / 12 VAL A 231
GLY A  44
ILE A 103
LEU A 105
LEU A  46
 None
 1.01A 4qdjA-3rp2A:
undetectable		 4qdjA-3rp2A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_B_ADNB301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 3rp2 RAT MAST CELL
PROTEASE II
(Rattus
rattus) 		5 / 9 PRO A 198
LEU A  33
ILE A 212
LEU A  53
THR A  54
 None
 1.21A 4x3mB-3rp2A:
undetectable		 4x3mB-3rp2A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_C_SAMC4000_0
(NS5
METHYLTRANSFERASE)		 3rp2 RAT MAST CELL
PROTEASE II
(Rattus
rattus) 		6 / 12 GLY A 142
GLY A  44
GLY A 196
GLY A 193
THR A  54
VAL A  52
 None
 1.28A 5eiwC-3rp2A:
undetectable		 5eiwC-3rp2A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3rp2 RAT MAST CELL
PROTEASE II
(Rattus
rattus) 		4 / 6 TYR A 234
HIS A 101
ILE A  90
TYR A 215
 None
 1.01A 5ih0A-3rp2A:
undetectable		 5ih0A-3rp2A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 3rp2 RAT MAST CELL
PROTEASE II
(Rattus
rattus) 		3 / 3 HIS A  91
GLU A  92
TRP A 237
 None
 1.06A 5odiD-3rp2A:
undetectable		 5odiD-3rp2A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 3rp2 RAT MAST CELL
PROTEASE II
(Rattus
rattus) 		3 / 3 HIS A  91
GLU A  92
TRP A 237
 None
 0.92A 5odqD-3rp2A:
undetectable		 5odqD-3rp2A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODR_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 3rp2 RAT MAST CELL
PROTEASE II
(Rattus
rattus) 		3 / 3 HIS A  91
GLU A  92
TRP A 237
 None
 0.99A 5odrD-3rp2A:
undetectable		 5odrD-3rp2A:
19.47