SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rp7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_1
(POL POLYPROTEIN)		 3rp7 FLAVOPROTEIN
MONOOXYGENASE
(Klebsiella
pneumoniae) 		5 / 10 LEU A 275
ALA A 286
ILE A   6
GLY A   7
GLY A  12
 None
None
FAD  A 385 (-4.4A)
FAD  A 385 (-3.4A)
None
 1.09A 1k6cA-3rp7A:
undetectable		 1k6cA-3rp7A:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_C_DEXC3999_1
(GLUCOCORTICOID
RECEPTOR)		 3rp7 FLAVOPROTEIN
MONOOXYGENASE
(Klebsiella
pneumoniae) 		5 / 12 GLY A 295
ARG A 204
MET A  71
LEU A  87
THR A  94
 URC  A7579 ( 3.5A)
URC  A7579 (-2.9A)
None
None
None
 1.48A 1p93C-3rp7A:
undetectable		 1p93C-3rp7A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3rp7 FLAVOPROTEIN
MONOOXYGENASE
(Klebsiella
pneumoniae) 		5 / 12 ALA A 327
VAL A 311
ALA A 310
PHE A 312
LEU A  19
 None
 1.00A 1uduB-3rp7A:
undetectable		 1uduB-3rp7A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1104_0
(FERROCHELATASE)		 3rp7 FLAVOPROTEIN
MONOOXYGENASE
(Klebsiella
pneumoniae) 		3 / 3 LEU A 223
PRO A 224
LEU A 227
 None
 0.48A 2qd5B-3rp7A:
undetectable		 2qd5B-3rp7A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3rp7 FLAVOPROTEIN
MONOOXYGENASE
(Klebsiella
pneumoniae) 		4 / 8 MET A 302
ALA A 301
GLY A  11
ILE A  10
 None
FAD  A 385 ( 4.5A)
FAD  A 385 (-3.5A)
FAD  A 385 (-4.1A)
 0.89A 2zm9A-3rp7A:
undetectable		 2zm9A-3rp7A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC505_2
(PHOSPHOLIPASE A2)		 3rp7 FLAVOPROTEIN
MONOOXYGENASE
(Klebsiella
pneumoniae) 		4 / 5 VAL A 210
GLN A 194
PHE A 217
ARG A  70
 None
 1.28A 3bjwH-3rp7A:
0.0		 3bjwH-3rp7A:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_2
(PHOSPHOLIPASE A2)		 3rp7 FLAVOPROTEIN
MONOOXYGENASE
(Klebsiella
pneumoniae) 		4 / 6 VAL A 210
GLN A 194
PHE A 217
ARG A  70
 None
 1.25A 3bjwF-3rp7A:
0.2		 3bjwF-3rp7A:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 3rp7 FLAVOPROTEIN
MONOOXYGENASE
(Klebsiella
pneumoniae) 		5 / 12 GLY A 284
GLY A 155
ILE A  10
ALA A 300
LEU A 282
 FAD  A 385 (-3.4A)
FAD  A 385 (-3.7A)
FAD  A 385 (-4.1A)
None
None
 1.13A 3ckkA-3rp7A:
undetectable		 3ckkA-3rp7A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_1
(PROTEASE)		 3rp7 FLAVOPROTEIN
MONOOXYGENASE
(Klebsiella
pneumoniae) 		5 / 10 ALA A  15
ILE A  24
GLY A 309
ALA A 281
ILE A 151
 None
 1.00A 3ekwA-3rp7A:
undetectable		 3ekwA-3rp7A:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3rp7 FLAVOPROTEIN
MONOOXYGENASE
(Klebsiella
pneumoniae) 		4 / 5 SER A 206
ASP A 293
ASP A 345
ILE A 346
 None
 1.37A 3uj7B-3rp7A:
undetectable		 3uj7B-3rp7A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3rp7 FLAVOPROTEIN
MONOOXYGENASE
(Klebsiella
pneumoniae) 		3 / 3 SER A 146
LEU A  -5
MET A   1
 None
 0.62A 5ikrB-3rp7A:
undetectable		 5ikrB-3rp7A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_2
(CYTOCHROME P450 3A4)		 3rp7 FLAVOPROTEIN
MONOOXYGENASE
(Klebsiella
pneumoniae) 		4 / 7 ARG A 263
ILE A 264
PHE A 217
ARG A 235
 None
 1.00A 5vc0A-3rp7A:
undetectable		 5vc0A-3rp7A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_C_SALC201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3rp7 FLAVOPROTEIN
MONOOXYGENASE
(Klebsiella
pneumoniae) 		4 / 7 ARG A 116
VAL A  28
GLY A 115
TYR A 113
 None
 1.00A 5x80C-3rp7A:
undetectable
5x80D-3rp7A:
undetectable		 5x80C-3rp7A:
22.36
5x80D-3rp7A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3rp7 FLAVOPROTEIN
MONOOXYGENASE
(Klebsiella
pneumoniae) 		4 / 5 ARG A  74
MET A  82
THR A  83
LEU A 362
 None
 1.32A 6nknW-3rp7A:
undetectable		 6nknW-3rp7A:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 3rp7 FLAVOPROTEIN
MONOOXYGENASE
(Klebsiella
pneumoniae) 		3 / 3 ASP A 112
LEU A 111
ARG A 103
 None
None
FAD  A 385 (-4.7A)
 0.84A 7dfrA-3rp7A:
undetectable		 7dfrA-3rp7A:
17.80