SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rp9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)		 3rp9 MITOGEN-ACTIVATED
PROTEIN KINASE
(Toxoplasma
gondii) 		4 / 6 LEU A  93
PHE A 129
ASP A 125
GLU A 428
 None
 1.13A 2vn1B-3rp9A:
undetectable		 2vn1B-3rp9A:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_A_ACTA501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 3rp9 MITOGEN-ACTIVATED
PROTEIN KINASE
(Toxoplasma
gondii) 		4 / 7 ARG A 180
ARG A 250
ILE A 255
TYR A 261
 None
 1.15A 2yfbA-3rp9A:
2.5		 2yfbA-3rp9A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_B_ACTB501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 3rp9 MITOGEN-ACTIVATED
PROTEIN KINASE
(Toxoplasma
gondii) 		4 / 6 ARG A 180
ARG A 250
ILE A 255
TYR A 261
 None
 1.12A 2yfbB-3rp9A:
2.7		 2yfbB-3rp9A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZSE_A_PAUA600_0
(PANTOTHENATE KINASE)		 3rp9 MITOGEN-ACTIVATED
PROTEIN KINASE
(Toxoplasma
gondii) 		4 / 7 PHE A 435
PHE A 129
ILE A 103
ASN A 107
 None
 1.03A 2zseA-3rp9A:
undetectable		 2zseA-3rp9A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_A_NILA600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3rp9 MITOGEN-ACTIVATED
PROTEIN KINASE
(Toxoplasma
gondii) 		5 / 10 VAL A  69
LYS A  84
VAL A 115
VAL A 197
ASP A 199
 None
 0.80A 3cs9A-3rp9A:
15.7		 3cs9A-3rp9A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3rp9 MITOGEN-ACTIVATED
PROTEIN KINASE
(Toxoplasma
gondii) 		4 / 8 GLU A 102
ASN A 186
HIS A 179
LYS A 183
 None
 1.26A 3kp6A-3rp9A:
undetectable
3kp6B-3rp9A:
undetectable		 3kp6A-3rp9A:
18.40
3kp6B-3rp9A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZV_B_ECNB411_1
(FLAVOHEMOGLOBIN)		 3rp9 MITOGEN-ACTIVATED
PROTEIN KINASE
(Toxoplasma
gondii) 		5 / 9 ILE A 273
ILE A 270
PHE A 274
LEU A 165
LEU A 277
 None
 1.01A 3ozvB-3rp9A:
undetectable		 3ozvB-3rp9A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3rp9 MITOGEN-ACTIVATED
PROTEIN KINASE
(Toxoplasma
gondii) 		5 / 8 VAL A 114
VAL A 115
LEU A 188
CYH A 198
ASP A 199
 None
 0.78A 3wzeA-3rp9A:
19.2		 3wzeA-3rp9A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR4_C_AICC401_1
(OUTER MEMBRANE
PROTEIN F)		 3rp9 MITOGEN-ACTIVATED
PROTEIN KINASE
(Toxoplasma
gondii) 		4 / 8 TYR A 208
ARG A 204
ARG A 180
GLU A 343
 SO4  A 459 (-4.8A)
None
None
None
 1.34A 4kr4C-3rp9A:
undetectable		 4kr4C-3rp9A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3rp9 MITOGEN-ACTIVATED
PROTEIN KINASE
(Toxoplasma
gondii) 		4 / 6 ASN A 284
GLU A 155
TYR A 152
GLU A 283
 None
 1.19A 4mi4A-3rp9A:
undetectable		 4mi4A-3rp9A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3rp9 MITOGEN-ACTIVATED
PROTEIN KINASE
(Toxoplasma
gondii) 		4 / 8 ASN A 284
GLU A 155
TYR A 152
GLU A 283
 None
 1.19A 4mj8A-3rp9A:
undetectable
4mj8C-3rp9A:
undetectable		 4mj8A-3rp9A:
19.04
4mj8C-3rp9A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_C_PACC601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 3rp9 MITOGEN-ACTIVATED
PROTEIN KINASE
(Toxoplasma
gondii) 		5 / 12 PRO A 184
PHE A 147
ILE A 273
VAL A 189
VAL A 195
 None
 1.48A 4yfbC-3rp9A:
0.0		 4yfbC-3rp9A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_I_PACI601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 3rp9 MITOGEN-ACTIVATED
PROTEIN KINASE
(Toxoplasma
gondii) 		5 / 12 PRO A 184
PHE A 147
ILE A 273
VAL A 189
VAL A 195
 None
 1.49A 4yfbI-3rp9A:
undetectable		 4yfbI-3rp9A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_L_PACL601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 3rp9 MITOGEN-ACTIVATED
PROTEIN KINASE
(Toxoplasma
gondii) 		5 / 12 PRO A 184
PHE A 147
ILE A 273
VAL A 189
VAL A 195
 None
 1.50A 4yfbL-3rp9A:
undetectable		 4yfbL-3rp9A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 3rp9 MITOGEN-ACTIVATED
PROTEIN KINASE
(Toxoplasma
gondii) 		5 / 10 ARG A 432
PHE A 435
ILE A 103
ASP A 119
TYR A  55
 None
 1.34A 5x66D-3rp9A:
undetectable		 5x66D-3rp9A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_2
(CYTOCHROME P450 2C9)		 3rp9 MITOGEN-ACTIVATED
PROTEIN KINASE
(Toxoplasma
gondii) 		4 / 4 PHE A 143
LEU A 395
LEU A 162
VAL A 169
 None
 1.14A 5xxiA-3rp9A:
undetectable		 5xxiA-3rp9A:
20.58