SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rpd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_A_ADNA252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3rpd METHIONINE SYNTHASE
(B12-INDEPENDENT)
(Shewanella
sp.
W3-18-1) 		5 / 11 ARG A 159
GLY A 203
VAL A 199
GLU A 198
ILE A 204
 None
 1.41A 1vhwA-3rpdA:
undetectable
1vhwD-3rpdA:
undetectable		 1vhwA-3rpdA:
19.95
1vhwD-3rpdA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_E_ADNE252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3rpd METHIONINE SYNTHASE
(B12-INDEPENDENT)
(Shewanella
sp.
W3-18-1) 		5 / 11 ARG A 159
GLY A 203
VAL A 199
GLU A 198
ILE A 204
 None
 1.41A 1vhwC-3rpdA:
undetectable
1vhwE-3rpdA:
undetectable		 1vhwC-3rpdA:
19.95
1vhwE-3rpdA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		 3rpd METHIONINE SYNTHASE
(B12-INDEPENDENT)
(Shewanella
sp.
W3-18-1) 		4 / 8 LEU A  58
SER A  70
LEU A 129
ASP A  71
 None
 1.02A 2j2pA-3rpdA:
undetectable
2j2pB-3rpdA:
undetectable		 2j2pA-3rpdA:
21.33
2j2pB-3rpdA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_A_SAMA301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 3rpd METHIONINE SYNTHASE
(B12-INDEPENDENT)
(Shewanella
sp.
W3-18-1) 		5 / 12 ILE A 204
GLY A 203
VAL A 199
ILE A 148
ALA A 205
 None
 1.02A 3fpjA-3rpdA:
undetectable		 3fpjA-3rpdA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)		 3rpd METHIONINE SYNTHASE
(B12-INDEPENDENT)
(Shewanella
sp.
W3-18-1) 		4 / 7 GLY A 225
PHE A  83
PHE A 122
PHE A  79
 ZN  A 355 ( 4.7A)
None
None
None
 1.10A 3ko0L-3rpdA:
undetectable
3ko0N-3rpdA:
undetectable		 3ko0L-3rpdA:
16.20
3ko0N-3rpdA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3rpd METHIONINE SYNTHASE
(B12-INDEPENDENT)
(Shewanella
sp.
W3-18-1) 		5 / 9 ALA A 140
TYR A 245
ILE A 260
ASP A 188
THR A 320
 None
 1.37A 3rukC-3rpdA:
0.6		 3rukC-3rpdA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_C_ACTC4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 3rpd METHIONINE SYNTHASE
(B12-INDEPENDENT)
(Shewanella
sp.
W3-18-1) 		4 / 4 GLY A  21
GLY A 323
THR A 320
LEU A 336
 None
 0.95A 3si7C-3rpdA:
undetectable
3si7D-3rpdA:
undetectable		 3si7C-3rpdA:
22.37
3si7D-3rpdA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_D_SAMD300_0
(PUTATIVE
METHYLTRANSFERASE)		 3rpd METHIONINE SYNTHASE
(B12-INDEPENDENT)
(Shewanella
sp.
W3-18-1) 		5 / 12 GLN A  74
GLY A  21
GLY A  72
GLN A  61
PHE A  79
 None
 1.31A 3t7sD-3rpdA:
undetectable		 3t7sD-3rpdA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAY_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 3rpd METHIONINE SYNTHASE
(B12-INDEPENDENT)
(Shewanella
sp.
W3-18-1) 		5 / 10 ARG A 159
GLY A 203
VAL A 199
GLU A 198
ILE A 204
 None
 1.28A 3uayA-3rpdA:
undetectable		 3uayA-3rpdA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3rpd METHIONINE SYNTHASE
(B12-INDEPENDENT)
(Shewanella
sp.
W3-18-1) 		3 / 3 ASP A 125
ARG A 117
THR A  75
 None
 0.38A 4i13A-3rpdA:
undetectable		 4i13A-3rpdA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_B_SHHB408_1
(HISTONE DEACETYLASE
2)		 3rpd METHIONINE SYNTHASE
(B12-INDEPENDENT)
(Shewanella
sp.
W3-18-1) 		5 / 11 HIS A  78
PHE A  79
HIS A 221
GLY A 323
TYR A 226
 None
None
ZN  A 355 (-3.3A)
None
None
 1.19A 4lxzB-3rpdA:
undetectable		 4lxzB-3rpdA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3rpd METHIONINE SYNTHASE
(B12-INDEPENDENT)
(Shewanella
sp.
W3-18-1) 		3 / 3 ASP A 125
ARG A 117
THR A  75
 None
 0.39A 4p3rA-3rpdA:
undetectable		 4p3rA-3rpdA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDC_A_ASDA404_1
(3-KETOSTEROID
9ALPHA-HYDROXYLASE
OXYGENASE)		 3rpd METHIONINE SYNTHASE
(B12-INDEPENDENT)
(Shewanella
sp.
W3-18-1) 		5 / 12 GLN A 186
LEU A 262
ALA A 219
LEU A 252
PHE A 249
 None
 1.41A 4qdcA-3rpdA:
undetectable		 4qdcA-3rpdA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)		 3rpd METHIONINE SYNTHASE
(B12-INDEPENDENT)
(Shewanella
sp.
W3-18-1) 		6 / 9 ALA A 140
TYR A 245
ILE A 260
ASP A 188
ALA A  20
THR A 320
 None
 1.44A 4r1zA-3rpdA:
undetectable		 4r1zA-3rpdA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_A_5OGA804_1
(HDAC6 PROTEIN)		 3rpd METHIONINE SYNTHASE
(B12-INDEPENDENT)
(Shewanella
sp.
W3-18-1) 		5 / 12 HIS A  78
PHE A  79
HIS A 221
GLY A 323
TYR A 226
 None
None
ZN  A 355 (-3.3A)
None
None
 1.32A 5eenA-3rpdA:
undetectable		 5eenA-3rpdA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_1
(ADENOSINE KINASE)		 3rpd METHIONINE SYNTHASE
(B12-INDEPENDENT)
(Shewanella
sp.
W3-18-1) 		5 / 12 LEU A 308
GLY A 285
ASN A 321
ALA A 307
LEU A 316
 None
 1.00A 5kb5A-3rpdA:
undetectable		 5kb5A-3rpdA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB307_0
(WELO5)		 3rpd METHIONINE SYNTHASE
(B12-INDEPENDENT)
(Shewanella
sp.
W3-18-1) 		3 / 3 GLU A 165
HIS A 155
VAL A 115
 None
 0.92A 5trqB-3rpdA:
undetectable		 5trqB-3rpdA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7U_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 3rpd METHIONINE SYNTHASE
(B12-INDEPENDENT)
(Shewanella
sp.
W3-18-1) 		4 / 6 VAL A 220
ASN A 256
ILE A 211
GLU A 208
 None
 0.90A 6h7uA-3rpdA:
undetectable		 6h7uA-3rpdA:
21.74