SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rpk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4003_1
(SERUM ALBUMIN)		 3rpk BACKBONE PILUS
SUBUNIT
(Streptococcus
pneumoniae) 		5 / 9 ILE A 535
ASN A 538
PHE A 541
LEU A 478
GLY A 567
 None
 0.89A 1e7bA-3rpkA:
undetectable		 1e7bA-3rpkA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_B_ESTB354_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 3rpk BACKBONE PILUS
SUBUNIT
(Streptococcus
pneumoniae) 		4 / 8 VAL A 426
LEU A 347
PRO A 334
VAL A 381
 None
 0.93A 1fduB-3rpkA:
undetectable		 1fduB-3rpkA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK5_A_T44A1008_1
(SERUM ALBUMIN)		 3rpk BACKBONE PILUS
SUBUNIT
(Streptococcus
pneumoniae) 		5 / 10 ASP A 548
GLU A 576
LYS A 554
VAL A 553
VAL A 544
 None
 1.18A 1hk5A-3rpkA:
2.9		 1hk5A-3rpkA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FCN_B_DVAB35_0
(UBIQUITIN)		 3rpk BACKBONE PILUS
SUBUNIT
(Streptococcus
pneumoniae) 		4 / 6 LEU A 231
GLN A 292
GLU A 295
ILE A 228
 None
 1.05A 2fcnA-3rpkA:
undetectable
2fcnB-3rpkA:
undetectable		 2fcnA-3rpkA:
8.67
2fcnB-3rpkA:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_2
(PROTEASE RETROPEPSIN)		 3rpk BACKBONE PILUS
SUBUNIT
(Streptococcus
pneumoniae) 		3 / 3 ARG A 480
THR A 496
VAL A 493
 None
 0.46A 2q64A-3rpkA:
undetectable		 2q64A-3rpkA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 3rpk BACKBONE PILUS
SUBUNIT
(Streptococcus
pneumoniae) 		3 / 3 ARG A 480
THR A 496
VAL A 493
 None
 0.71A 2qakA-3rpkA:
undetectable		 2qakA-3rpkA:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 3rpk BACKBONE PILUS
SUBUNIT
(Streptococcus
pneumoniae) 		5 / 12 TYR A 234
PRO A 434
ASN A 238
ASP A 241
VAL A 320
 None
 1.23A 2zznA-3rpkA:
undetectable		 2zznA-3rpkA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3rpk BACKBONE PILUS
SUBUNIT
(Streptococcus
pneumoniae) 		3 / 3 ASP A 259
LYS A 288
LEU A 281
 None
 0.98A 4ptjA-3rpkA:
undetectable		 4ptjA-3rpkA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_G_SAMG301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3rpk BACKBONE PILUS
SUBUNIT
(Streptococcus
pneumoniae) 		5 / 12 ALA A 372
PRO A 315
THR A 446
GLY A 246
THR A 305
 None
 1.42A 5hfjG-3rpkA:
undetectable		 5hfjG-3rpkA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		 3rpk BACKBONE PILUS
SUBUNIT
(Streptococcus
pneumoniae) 		3 / 3 ASP A 209
ASP A 319
ASN A 323
 None
 0.62A 6gngB-3rpkA:
undetectable		 6gngB-3rpkA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3rpk BACKBONE PILUS
SUBUNIT
(Streptococcus
pneumoniae) 		4 / 8 TRP A 239
ASP A 319
ARG A 242
ASP A 278
 None
 1.20A 6mn4A-3rpkA:
undetectable		 6mn4A-3rpkA:
18.17