SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rpl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 3rpl D-FRUCTOSE
1,6-BISPHOSPHATASE
CLASS
2/SEDOHEPTULOSE
1,7-BISPHOSPHATASE
(Synechocystis
sp.
PCC
6803) 		4 / 7 ALA A 204
SER A 206
ILE A 214
ILE A 196
 None
 0.87A 1yc5A-3rplA:
undetectable		 1yc5A-3rplA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		 3rpl D-FRUCTOSE
1,6-BISPHOSPHATASE
CLASS
2/SEDOHEPTULOSE
1,7-BISPHOSPHATASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 LEU A 302
LEU A 318
ILE A 205
ALA A 293
PHE A 292
 None
 0.93A 2qb4A-3rplA:
undetectable		 2qb4A-3rplA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QJU_A_DSMA801_1
(TRANSPORTER)		 3rpl D-FRUCTOSE
1,6-BISPHOSPHATASE
CLASS
2/SEDOHEPTULOSE
1,7-BISPHOSPHATASE
(Synechocystis
sp.
PCC
6803) 		5 / 11 LEU A 302
LEU A 318
ILE A 205
ALA A 293
PHE A 292
 None
 0.92A 2qjuA-3rplA:
undetectable		 2qjuA-3rplA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_2
(CYTOCHROME P450 2R1)		 3rpl D-FRUCTOSE
1,6-BISPHOSPHATASE
CLASS
2/SEDOHEPTULOSE
1,7-BISPHOSPHATASE
(Synechocystis
sp.
PCC
6803) 		3 / 3 MET A  44
VAL A  13
GLU A   8
 None
 0.81A 3c6gA-3rplA:
undetectable		 3c6gA-3rplA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 3rpl D-FRUCTOSE
1,6-BISPHOSPHATASE
CLASS
2/SEDOHEPTULOSE
1,7-BISPHOSPHATASE
(Synechocystis
sp.
PCC
6803) 		4 / 8 ARG A 178
ASP A 129
GLU A  57
GLU A 225
 FBP  A 350 ( 2.6A)
None
MG  A 348 (-3.3A)
MG  A 347 ( 3.4A)
 1.30A 3dh0A-3rplA:
undetectable		 3dh0A-3rplA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB500_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3rpl D-FRUCTOSE
1,6-BISPHOSPHATASE
CLASS
2/SEDOHEPTULOSE
1,7-BISPHOSPHATASE
(Synechocystis
sp.
PCC
6803) 		4 / 7 THR A 332
VAL A 313
THR A 315
VAL A 306
 None
 0.43A 3em0B-3rplA:
2.3		 3em0B-3rplA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWW_A_SFXA801_1
(TRANSPORTER)		 3rpl D-FRUCTOSE
1,6-BISPHOSPHATASE
CLASS
2/SEDOHEPTULOSE
1,7-BISPHOSPHATASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 LEU A 302
LEU A 318
ILE A 205
ALA A 293
PHE A 292
 None
 0.80A 3gwwA-3rplA:
undetectable		 3gwwA-3rplA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_2
(DIHYDROFOLATE
REDUCTASE)		 3rpl D-FRUCTOSE
1,6-BISPHOSPHATASE
CLASS
2/SEDOHEPTULOSE
1,7-BISPHOSPHATASE
(Synechocystis
sp.
PCC
6803) 		4 / 4 ILE A  92
ARG A  43
ILE A  94
THR A 289
 None
 1.06A 3ia4C-3rplA:
undetectable		 3ia4C-3rplA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_2
(DIHYDROFOLATE
REDUCTASE)		 3rpl D-FRUCTOSE
1,6-BISPHOSPHATASE
CLASS
2/SEDOHEPTULOSE
1,7-BISPHOSPHATASE
(Synechocystis
sp.
PCC
6803) 		3 / 3 ARG A  43
ILE A  94
THR A 289
 None
 0.40A 3ia4D-3rplA:
undetectable		 3ia4D-3rplA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_2
(CYTOCHROME P450
21-HYDROXYLASE)		 3rpl D-FRUCTOSE
1,6-BISPHOSPHATASE
CLASS
2/SEDOHEPTULOSE
1,7-BISPHOSPHATASE
(Synechocystis
sp.
PCC
6803) 		3 / 3 LEU A 104
VAL A 201
ASP A 200
 None
None
FBP  A 350 (-2.8A)
 0.69A 4y8wC-3rplA:
undetectable		 4y8wC-3rplA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 3rpl D-FRUCTOSE
1,6-BISPHOSPHATASE
CLASS
2/SEDOHEPTULOSE
1,7-BISPHOSPHATASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 ILE A 186
GLY A 219
ILE A 157
ALA A 141
LEU A 162
 None
 1.06A 5e72A-3rplA:
undetectable		 5e72A-3rplA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_C_SAMC301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3rpl D-FRUCTOSE
1,6-BISPHOSPHATASE
CLASS
2/SEDOHEPTULOSE
1,7-BISPHOSPHATASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 ASP A  33
ALA A  36
GLN A 316
GLY A 296
GLU A 100
 MG  A 348 (-3.0A)
None
None
None
FBP  A 350 ( 3.1A)
 1.31A 5hfjC-3rplA:
undetectable		 5hfjC-3rplA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7P_A_SAMA501_0
(OXAC)		 3rpl D-FRUCTOSE
1,6-BISPHOSPHATASE
CLASS
2/SEDOHEPTULOSE
1,7-BISPHOSPHATASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 GLU A  14
ALA A 293
SER A 317
VAL A 330
LEU A   5
 None
 1.05A 5w7pA-3rplA:
undetectable		 5w7pA-3rplA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3rpl D-FRUCTOSE
1,6-BISPHOSPHATASE
CLASS
2/SEDOHEPTULOSE
1,7-BISPHOSPHATASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 TYR A 279
LEU A 284
ILE A 228
MET A 132
LEU A 267
 None
 1.22A 5y2tA-3rplA:
undetectable		 5y2tA-3rplA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3rpl D-FRUCTOSE
1,6-BISPHOSPHATASE
CLASS
2/SEDOHEPTULOSE
1,7-BISPHOSPHATASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 TYR A 279
LEU A 284
ILE A 228
MET A 132
LEU A 267
 None
 1.24A 5ycpA-3rplA:
undetectable		 5ycpA-3rplA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_B_EY4B500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3rpl D-FRUCTOSE
1,6-BISPHOSPHATASE
CLASS
2/SEDOHEPTULOSE
1,7-BISPHOSPHATASE
(Synechocystis
sp.
PCC
6803) 		4 / 6 GLN A 109
VAL A 105
ALA A  32
THR A  31
 None
 0.95A 6cduB-3rplA:
1.9
6cduC-3rplA:
undetectable		 6cduB-3rplA:
21.17
6cduC-3rplA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 3rpl D-FRUCTOSE
1,6-BISPHOSPHATASE
CLASS
2/SEDOHEPTULOSE
1,7-BISPHOSPHATASE
(Synechocystis
sp.
PCC
6803) 		5 / 12 PHE A 125
GLY A 122
GLY A 287
SER A 119
VAL A 290
 None
 1.08A 6mhtA-3rplA:
undetectable		 6mhtA-3rplA:
22.56