SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rpw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B2I_A_AMHA84_1
(PROTEIN
(PLASMINOGEN))		 3rpw ABC TRANSPORTER
(Rhodopseudomonas
palustris) 		4 / 7 TYR A 261
GLU A 180
TRP A 332
PHE A  90
 GOL  A 363 (-4.5A)
None
None
GOL  A 363 (-4.3A)
 1.44A 1b2iA-3rpwA:
undetectable		 1b2iA-3rpwA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3rpw ABC TRANSPORTER
(Rhodopseudomonas
palustris) 		5 / 12 LEU A 281
LEU A 133
LEU A 293
ALA A 290
LEU A  45
 None
 1.10A 1g5yB-3rpwA:
undetectable		 1g5yB-3rpwA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2502_0
(FERROCHELATASE)		 3rpw ABC TRANSPORTER
(Rhodopseudomonas
palustris) 		4 / 8 MET A  34
LEU A 285
PRO A 268
GLY A 130
 None
 1.03A 1hrkB-3rpwA:
undetectable		 1hrkB-3rpwA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 3rpw ABC TRANSPORTER
(Rhodopseudomonas
palustris) 		5 / 12 PHE A  88
ALA A 219
GLY A  40
TYR A  41
GLN A 134
 GOL  A 363 (-4.6A)
GOL  A 364 (-3.4A)
None
GOL  A 364 (-4.9A)
None
 0.93A 1qabF-3rpwA:
undetectable		 1qabF-3rpwA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 3rpw ABC TRANSPORTER
(Rhodopseudomonas
palustris) 		5 / 12 GLY A  40
GLY A  39
GLY A  38
LEU A  45
PHE A 297
 None
FMT  A 370 (-3.8A)
FMT  A 370 (-3.7A)
None
GOL  A 364 (-4.9A)
 1.18A 1qzzA-3rpwA:
undetectable		 1qzzA-3rpwA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2003_1
(SERUM ALBUMIN)		 3rpw ABC TRANSPORTER
(Rhodopseudomonas
palustris) 		5 / 10 LEU A 118
LEU A 285
LEU A 281
ILE A 105
ALA A 132
 None
 1.11A 2bxeB-3rpwA:
undetectable		 2bxeB-3rpwA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXP_A_P1ZA3001_1
(SERUM ALBUMIN)		 3rpw ABC TRANSPORTER
(Rhodopseudomonas
palustris) 		5 / 12 LEU A 118
LEU A 285
LEU A 281
ILE A 105
ALA A 132
 None
 1.12A 2bxpA-3rpwA:
undetectable		 2bxpA-3rpwA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACTA544_0
(ACETYLCHOLINESTERASE)		 3rpw ABC TRANSPORTER
(Rhodopseudomonas
palustris) 		5 / 8 GLY A  38
GLY A  39
ALA A 219
ALA A 220
PHE A 297
 FMT  A 370 (-3.7A)
FMT  A 370 (-3.8A)
GOL  A 364 (-3.4A)
FMT  A 370 (-3.3A)
GOL  A 364 (-4.9A)
 1.00A 2ha4A-3rpwA:
undetectable		 2ha4A-3rpwA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_B_BEZB143_0
(PUTATIVE REDOX
PROTEIN)		 3rpw ABC TRANSPORTER
(Rhodopseudomonas
palustris) 		4 / 6 TYR A 237
THR A 218
ALA A  67
PRO A 222
 GOL  A 364 (-4.2A)
None
GOL  A 363 (-3.9A)
None
 1.42A 2ql8A-3rpwA:
undetectable
2ql8B-3rpwA:
undetectable		 2ql8A-3rpwA:
18.66
2ql8B-3rpwA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3rpw ABC TRANSPORTER
(Rhodopseudomonas
palustris) 		4 / 6 PRO A 342
SER A 341
GLU A 354
TYR A 351
 None
 1.37A 2x7hA-3rpwA:
undetectable		 2x7hA-3rpwA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 3rpw ABC TRANSPORTER
(Rhodopseudomonas
palustris) 		5 / 12 ALA A  44
ALA A 320
GLY A 239
THR A 238
TYR A 237
 None
None
GOL  A 364 (-3.4A)
None
GOL  A 364 (-4.2A)
 1.21A 2zifB-3rpwA:
undetectable		 2zifB-3rpwA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_2
(RENIN)		 3rpw ABC TRANSPORTER
(Rhodopseudomonas
palustris) 		4 / 4 VAL A 299
TYR A 237
PRO A 223
PHE A 297
 None
GOL  A 364 (-4.2A)
None
GOL  A 364 (-4.9A)
 1.40A 3d91B-3rpwA:
undetectable		 3d91B-3rpwA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA302_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 3rpw ABC TRANSPORTER
(Rhodopseudomonas
palustris) 		4 / 6 LEU A 140
GLY A 139
ALA A 152
PRO A 153
 None
 0.47A 3huoA-3rpwA:
undetectable		 3huoA-3rpwA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 3rpw ABC TRANSPORTER
(Rhodopseudomonas
palustris) 		5 / 12 TYR A 194
GLN A 257
ALA A 181
LEU A 183
GLY A 139
 None
 1.06A 3ozwB-3rpwA:
undetectable		 3ozwB-3rpwA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 3rpw ABC TRANSPORTER
(Rhodopseudomonas
palustris) 		4 / 7 TYR A 237
ILE A 136
GLN A 134
PHE A  88
 GOL  A 364 (-4.2A)
GOL  A 363 ( 4.5A)
None
GOL  A 363 (-4.6A)
 1.26A 3tvxB-3rpwA:
undetectable		 3tvxB-3rpwA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZTV_A_ADNA1600_1
(NAD NUCLEOTIDASE)		 3rpw ABC TRANSPORTER
(Rhodopseudomonas
palustris) 		5 / 9 GLY A  39
GLY A  40
PHE A 297
GLY A  38
ASP A  36
 FMT  A 370 (-3.8A)
None
GOL  A 364 (-4.9A)
FMT  A 370 (-3.7A)
None
 1.22A 3ztvA-3rpwA:
undetectable		 3ztvA-3rpwA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 3rpw ABC TRANSPORTER
(Rhodopseudomonas
palustris) 		4 / 6 LEU A 356
LEU A 205
ILE A 208
TRP A 156
 None
 1.00A 4do3B-3rpwA:
2.2		 4do3B-3rpwA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		 3rpw ABC TRANSPORTER
(Rhodopseudomonas
palustris) 		5 / 12 VAL A 135
LEU A 301
ALA A 290
LEU A  45
MET A  49
 None
 1.06A 4i1rA-3rpwA:
undetectable		 4i1rA-3rpwA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_ACTA502_0
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 3rpw ABC TRANSPORTER
(Rhodopseudomonas
palustris) 		4 / 4 LYS A 129
ARG A 127
GLY A 130
ASP A 104
 FMT  A 371 (-3.2A)
None
None
FMT  A 371 ( 3.5A)
 1.40A 4ryaA-3rpwA:
7.8		 4ryaA-3rpwA:
25.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		 3rpw ABC TRANSPORTER
(Rhodopseudomonas
palustris) 		5 / 12 GLU A 247
ILE A 251
PRO A 250
ASP A 145
ILE A 226
 FMT  A 375 ( 4.8A)
None
None
None
None
 1.28A 4uroC-3rpwA:
undetectable		 4uroC-3rpwA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3rpw ABC TRANSPORTER
(Rhodopseudomonas
palustris) 		4 / 7 PHE A 336
ILE A 196
ASN A 256
PHE A 177
 None
 0.97A 5hieC-3rpwA:
undetectable		 5hieC-3rpwA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEO_A_DHIA4_0
((DPR)PY(DHI)PKDL(DGN
))		 3rpw ABC TRANSPORTER
(Rhodopseudomonas
palustris) 		3 / 3 TYR A 237
PRO A 172
LEU A 235
 GOL  A 364 (-4.2A)
None
None
 0.91A 6beoA-3rpwA:
undetectable		 6beoA-3rpwA:
4.96