SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rq1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_A_MTXA171_1
(DIHYDROFOLATE
REDUCTASE)		 3rq1 AMINOTRANSFERASE
CLASS I AND II
(Veillonella
parvula) 		5 / 12 ALA A 365
ILE A 377
LEU A 401
ILE A 388
THR A 362
 None
 1.31A 1d1gA-3rq1A:
2.7		 1d1gA-3rq1A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3rq1 AMINOTRANSFERASE
CLASS I AND II
(Veillonella
parvula) 		6 / 12 ILE A 360
ALA A 365
ILE A 377
LEU A 401
ILE A 388
THR A 362
 None
 1.42A 1dhiA-3rq1A:
2.7		 1dhiA-3rq1A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3rq1 AMINOTRANSFERASE
CLASS I AND II
(Veillonella
parvula) 		6 / 11 ILE A 360
ALA A 365
ILE A 377
LEU A 401
ILE A 388
THR A 362
 None
 1.42A 1dhiB-3rq1A:
2.5		 1dhiB-3rq1A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3rq1 AMINOTRANSFERASE
CLASS I AND II
(Veillonella
parvula) 		6 / 12 ILE A 360
ALA A 365
ILE A 377
LEU A 401
ILE A 388
THR A 362
 None
 1.41A 1dhjA-3rq1A:
2.5		 1dhjA-3rq1A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3rq1 AMINOTRANSFERASE
CLASS I AND II
(Veillonella
parvula) 		6 / 12 ILE A 360
ALA A 365
ILE A 377
LEU A 401
ILE A 388
THR A 362
 None
 1.39A 1dhjB-3rq1A:
2.5		 1dhjB-3rq1A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3rq1 AMINOTRANSFERASE
CLASS I AND II
(Veillonella
parvula) 		6 / 12 ILE A 360
ALA A 365
ILE A 377
LEU A 401
ILE A 388
THR A 362
 None
 1.39A 1drbA-3rq1A:
2.7		 1drbA-3rq1A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3rq1 AMINOTRANSFERASE
CLASS I AND II
(Veillonella
parvula) 		6 / 12 ILE A 360
ALA A 365
ILE A 377
LEU A 401
ILE A 388
THR A 362
 None
 1.40A 1drbB-3rq1A:
2.6		 1drbB-3rq1A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_A_SAMA501_0
(BIOTIN SYNTHASE)		 3rq1 AMINOTRANSFERASE
CLASS I AND II
(Veillonella
parvula) 		5 / 12 TYR A 136
THR A 105
GLY A 269
LEU A 147
VAL A 126
 None
 1.18A 1r30A-3rq1A:
2.5		 1r30A-3rq1A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)		 3rq1 AMINOTRANSFERASE
CLASS I AND II
(Veillonella
parvula) 		5 / 12 TYR A 136
THR A 105
GLY A 269
LEU A 147
VAL A 126
 None
 1.18A 1r30B-3rq1A:
1.9		 1r30B-3rq1A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3rq1 AMINOTRANSFERASE
CLASS I AND II
(Veillonella
parvula) 		6 / 12 ILE A 360
ALA A 365
ILE A 377
LEU A 401
ILE A 388
THR A 362
 None
 1.48A 1ra2A-3rq1A:
2.4		 1ra2A-3rq1A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3rq1 AMINOTRANSFERASE
CLASS I AND II
(Veillonella
parvula) 		6 / 12 ILE A 360
ALA A 365
ILE A 377
LEU A 401
ILE A 388
THR A 362
 None
 1.47A 1ra3A-3rq1A:
2.5		 1ra3A-3rq1A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3rq1 AMINOTRANSFERASE
CLASS I AND II
(Veillonella
parvula) 		4 / 7 TYR A 352
GLY A 186
TYR A 328
ASP A 198
 None
 1.10A 2g72B-3rq1A:
undetectable		 2g72B-3rq1A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 3rq1 AMINOTRANSFERASE
CLASS I AND II
(Veillonella
parvula) 		5 / 9 PHE A  82
ALA A  85
ALA A 270
GLY A 269
ILE A 272
 None
 1.19A 2v7bA-3rq1A:
3.9		 2v7bA-3rq1A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 3rq1 AMINOTRANSFERASE
CLASS I AND II
(Veillonella
parvula) 		5 / 9 PHE A  82
ALA A  85
ALA A 270
GLY A 269
ILE A 272
 None
 1.19A 2v7bB-3rq1A:
4.0		 2v7bB-3rq1A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_1
(PHOSPHOLIPASE A2)		 3rq1 AMINOTRANSFERASE
CLASS I AND II
(Veillonella
parvula) 		4 / 5 VAL A 126
VAL A 179
THR A 143
THR A 128
 None
 1.10A 3bjwA-3rq1A:
undetectable		 3bjwA-3rq1A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_3
(PHOSPHOLIPASE A2)		 3rq1 AMINOTRANSFERASE
CLASS I AND II
(Veillonella
parvula) 		4 / 5 VAL A 126
VAL A 179
THR A 143
THR A 128
 None
 1.15A 3bjwG-3rq1A:
undetectable		 3bjwG-3rq1A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_1
(PHOSPHOLIPASE A2)		 3rq1 AMINOTRANSFERASE
CLASS I AND II
(Veillonella
parvula) 		4 / 5 VAL A 126
VAL A 179
THR A 143
THR A 128
 None
 1.13A 3bjwC-3rq1A:
undetectable		 3bjwC-3rq1A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_2
(PHOSPHOLIPASE A2)		 3rq1 AMINOTRANSFERASE
CLASS I AND II
(Veillonella
parvula) 		4 / 5 VAL A 126
VAL A 179
THR A 143
THR A 128
 None
 1.06A 3bjwD-3rq1A:
undetectable		 3bjwD-3rq1A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3rq1 AMINOTRANSFERASE
CLASS I AND II
(Veillonella
parvula) 		6 / 12 ILE A 360
ALA A 365
ILE A 377
LEU A 401
ILE A 388
THR A 362
 None
 1.40A 3drcB-3rq1A:
undetectable		 3drcB-3rq1A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B304_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 3rq1 AMINOTRANSFERASE
CLASS I AND II
(Veillonella
parvula) 		4 / 5 ASN A 187
THR A 109
SER A 258
ARG A 267
 None
None
None
OAA  A 422 (-3.7A)
 1.28A 3hlwB-3rq1A:
undetectable		 3hlwB-3rq1A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 3rq1 AMINOTRANSFERASE
CLASS I AND II
(Veillonella
parvula) 		4 / 6 ARG A  95
ARG A 101
GLY A 273
GLU A 286
 None
 1.10A 3k9fA-3rq1A:
undetectable
3k9fB-3rq1A:
0.9
3k9fD-3rq1A:
1.9		 3k9fA-3rq1A:
24.27
3k9fB-3rq1A:
24.27
3k9fD-3rq1A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP3_B_AICB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3rq1 AMINOTRANSFERASE
CLASS I AND II
(Veillonella
parvula) 		3 / 3 ALA A 106
ARG A 267
LYS A 259
 None
OAA  A 422 (-3.7A)
OAA  A 422 (-2.8A)
 0.96A 3kp3B-3rq1A:
1.4		 3kp3B-3rq1A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3rq1 AMINOTRANSFERASE
CLASS I AND II
(Veillonella
parvula) 		6 / 12 ILE A 360
ALA A 365
ILE A 377
LEU A 401
ILE A 388
THR A 362
 None
 1.41A 4x5iA-3rq1A:
undetectable		 4x5iA-3rq1A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3rq1 AMINOTRANSFERASE
CLASS I AND II
(Veillonella
parvula) 		5 / 12 GLY A  40
ILE A 112
TYR A 136
GLY A 110
GLY A 107
 None
 1.08A 5eqbA-3rq1A:
2.0		 5eqbA-3rq1A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3rq1 AMINOTRANSFERASE
CLASS I AND II
(Veillonella
parvula) 		5 / 12 ALA A  77
GLY A 269
SER A 256
SER A 102
TYR A 255
 None
 1.34A 5hfjB-3rq1A:
undetectable		 5hfjB-3rq1A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VYH_A_FOLA409_0
(S PROTEIN)		 3rq1 AMINOTRANSFERASE
CLASS I AND II
(Veillonella
parvula) 		5 / 10 TRP A 133
PRO A 189
ALA A 224
GLY A 108
THR A 109
 OAA  A 422 (-3.9A)
None
None
None
None
 1.22A 5vyhA-3rq1A:
undetectable		 5vyhA-3rq1A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_A_TRPA403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 3rq1 AMINOTRANSFERASE
CLASS I AND II
(Veillonella
parvula) 		4 / 8 TRP A 199
THR A 184
PRO A 185
ILE A 221
 None
 1.09A 6a4iA-3rq1A:
undetectable		 6a4iA-3rq1A:
22.15