SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rqz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3rqz METALLOPHOSPHOESTERA
SE
(Sphaerobacter
thermophilus) 		3 / 3 ASP A  34
HIS A  62
HIS A  10
 ZN  A 301 ( 3.2A)
None
ZN  A 301 (-3.4A)
 0.65A 1oe1A-3rqzA:
undetectable		 1oe1A-3rqzA:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3rqz METALLOPHOSPHOESTERA
SE
(Sphaerobacter
thermophilus) 		3 / 3 ASP A  34
HIS A  62
HIS A  10
 ZN  A 301 ( 3.2A)
None
ZN  A 301 (-3.4A)
 0.65A 1oe3A-3rqzA:
undetectable		 1oe3A-3rqzA:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F0Z_A_ZMRA381_1
(SIALIDASE 2)		 3rqz METALLOPHOSPHOESTERA
SE
(Sphaerobacter
thermophilus) 		5 / 12 ASN A  61
TYR A 124
ARG A 192
ARG A 238
TYR A  38
 ZN  A 302 (-3.3A)
None
None
None
None
 1.37A 2f0zA-3rqzA:
undetectable		 2f0zA-3rqzA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F10_A_BCZA382_0
(SIALIDASE 2)		 3rqz METALLOPHOSPHOESTERA
SE
(Sphaerobacter
thermophilus) 		5 / 12 ASN A  61
TYR A 124
ARG A 192
ARG A 238
TYR A  38
 ZN  A 302 (-3.3A)
None
None
None
None
 1.35A 2f10A-3rqzA:
undetectable		 2f10A-3rqzA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4K_A_DR7A301_2
(PROTEASE)		 3rqz METALLOPHOSPHOESTERA
SE
(Sphaerobacter
thermophilus) 		6 / 12 ASP A  63
GLY A  60
VAL A   9
ILE A   6
VAL A  46
ILE A  35
 None
 1.49A 2o4kB-3rqzA:
undetectable		 2o4kB-3rqzA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_2
(ANGIOTENSIN
CONVERTING ENZYME)		 3rqz METALLOPHOSPHOESTERA
SE
(Sphaerobacter
thermophilus) 		3 / 3 SER A 116
THR A 148
PHE A 212
 None
 0.78A 2x91A-3rqzA:
undetectable		 2x91A-3rqzA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3rqz METALLOPHOSPHOESTERA
SE
(Sphaerobacter
thermophilus) 		3 / 3 ASP A  34
HIS A  62
HIS A  10
 ZN  A 301 ( 3.2A)
None
ZN  A 301 (-3.4A)
 0.66A 2xxgA-3rqzA:
undetectable		 2xxgA-3rqzA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_C_CUC1339_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3rqz METALLOPHOSPHOESTERA
SE
(Sphaerobacter
thermophilus) 		3 / 3 ASP A  34
HIS A  62
HIS A  10
 ZN  A 301 ( 3.2A)
None
ZN  A 301 (-3.4A)
 0.67A 2xxgC-3rqzA:
undetectable		 2xxgC-3rqzA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWE_B_DAHB98_1
(TYROSINASE
MELC)		 3rqz METALLOPHOSPHOESTERA
SE
(Sphaerobacter
thermophilus) 		5 / 11 HIS A  10
HIS A 149
HIS A 147
HIS A 114
VAL A 113
 ZN  A 301 (-3.4A)
ZN  A 301 (-3.5A)
ZN  A 302 (-3.3A)
ZN  A 302 (-4.2A)
None
 1.18A 2zweA-3rqzA:
undetectable
2zweB-3rqzA:
undetectable		 2zweA-3rqzA:
20.68
2zweB-3rqzA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWF_B_DAHB98_1
(TYROSINASE
MELC)		 3rqz METALLOPHOSPHOESTERA
SE
(Sphaerobacter
thermophilus) 		5 / 11 HIS A  10
HIS A 149
HIS A 147
HIS A 114
VAL A 113
 ZN  A 301 (-3.4A)
ZN  A 301 (-3.5A)
ZN  A 302 (-3.3A)
ZN  A 302 (-4.2A)
None
 1.24A 2zwfA-3rqzA:
undetectable
2zwfB-3rqzA:
undetectable		 2zwfA-3rqzA:
20.68
2zwfB-3rqzA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWG_B_DAHB98_1
(TYROSINASE
MELC)		 3rqz METALLOPHOSPHOESTERA
SE
(Sphaerobacter
thermophilus) 		5 / 11 HIS A  10
HIS A 149
HIS A 147
HIS A 114
VAL A 113
 ZN  A 301 (-3.4A)
ZN  A 301 (-3.5A)
ZN  A 302 (-3.3A)
ZN  A 302 (-4.2A)
None
 1.27A 2zwgA-3rqzA:
undetectable
2zwgB-3rqzA:
undetectable		 2zwgA-3rqzA:
20.68
2zwgB-3rqzA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_2
(PROTEASE)		 3rqz METALLOPHOSPHOESTERA
SE
(Sphaerobacter
thermophilus) 		6 / 12 ASP A  63
GLY A  60
VAL A   9
ILE A   6
VAL A  46
ILE A  35
 None
 1.48A 3el1B-3rqzA:
undetectable		 3el1B-3rqzA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 3rqz METALLOPHOSPHOESTERA
SE
(Sphaerobacter
thermophilus) 		3 / 3 ASN A  61
ASP A  63
ARG A 214
 ZN  A 302 (-3.3A)
None
None
 0.92A 3k13C-3rqzA:
undetectable		 3k13C-3rqzA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_B_ZPCB1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3rqz METALLOPHOSPHOESTERA
SE
(Sphaerobacter
thermophilus) 		5 / 12 GLU A 158
GLU A 172
TYR A 153
VAL A 145
PHE A 212
 None
 1.23A 4a97A-3rqzA:
undetectable
4a97B-3rqzA:
undetectable		 4a97A-3rqzA:
23.84
4a97B-3rqzA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_A_SHHA700_1
(HISTONE DEACETYLASE
8)		 3rqz METALLOPHOSPHOESTERA
SE
(Sphaerobacter
thermophilus) 		5 / 10 HIS A  10
HIS A 149
ASP A  34
PRO A 120
GLY A  33
 ZN  A 301 (-3.4A)
ZN  A 301 (-3.5A)
ZN  A 301 ( 3.2A)
None
None
 1.47A 4bz6A-3rqzA:
undetectable		 4bz6A-3rqzA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_D_SHHD700_1
(HISTONE DEACETYLASE
8)		 3rqz METALLOPHOSPHOESTERA
SE
(Sphaerobacter
thermophilus) 		5 / 10 HIS A  10
HIS A 149
ASP A  34
PRO A 120
GLY A  33
 ZN  A 301 (-3.4A)
ZN  A 301 (-3.5A)
ZN  A 301 ( 3.2A)
None
None
 1.46A 4bz6D-3rqzA:
undetectable		 4bz6D-3rqzA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_2
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3rqz METALLOPHOSPHOESTERA
SE
(Sphaerobacter
thermophilus) 		4 / 4 LEU A  95
LEU A 101
GLN A  89
GLU A  47
 None
 1.27A 4i41A-3rqzA:
undetectable		 4i41A-3rqzA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JD1_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 3rqz METALLOPHOSPHOESTERA
SE
(Sphaerobacter
thermophilus) 		5 / 12 HIS A  10
TYR A  38
HIS A 149
TYR A 124
ASN A  61
 ZN  A 301 (-3.4A)
None
ZN  A 301 (-3.5A)
None
ZN  A 302 (-3.3A)
 1.04A 4jd1A-3rqzA:
undetectable
4jd1B-3rqzA:
undetectable		 4jd1A-3rqzA:
20.00
4jd1B-3rqzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JD1_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 3rqz METALLOPHOSPHOESTERA
SE
(Sphaerobacter
thermophilus) 		5 / 12 HIS A 149
TYR A 124
ASN A  61
HIS A  10
TYR A  38
 ZN  A 301 (-3.5A)
None
ZN  A 302 (-3.3A)
ZN  A 301 (-3.4A)
None
 1.11A 4jd1A-3rqzA:
undetectable
4jd1B-3rqzA:
undetectable		 4jd1A-3rqzA:
20.00
4jd1B-3rqzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH3_A_FCNA204_1
(METALLOTHIOL
TRANSFERASE FOSB)		 3rqz METALLOPHOSPHOESTERA
SE
(Sphaerobacter
thermophilus) 		5 / 12 HIS A  10
TYR A  38
HIS A 149
TYR A 124
ASN A  61
 ZN  A 301 (-3.4A)
None
ZN  A 301 (-3.5A)
None
ZN  A 302 (-3.3A)
 1.05A 4jh3A-3rqzA:
undetectable
4jh3B-3rqzA:
undetectable		 4jh3A-3rqzA:
22.42
4jh3B-3rqzA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 3rqz METALLOPHOSPHOESTERA
SE
(Sphaerobacter
thermophilus) 		5 / 12 GLY A 115
ILE A 182
ILE A 121
ASN A 103
ASN A  61
 None
None
None
None
ZN  A 302 (-3.3A)
 1.18A 5fa8A-3rqzA:
undetectable		 5fa8A-3rqzA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_A_1FLA1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 3rqz METALLOPHOSPHOESTERA
SE
(Sphaerobacter
thermophilus) 		4 / 8 PRO A 117
ILE A 125
PRO A 165
LEU A 152
 None
 0.76A 5g48A-3rqzA:
undetectable		 5g48A-3rqzA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3rqz METALLOPHOSPHOESTERA
SE
(Sphaerobacter
thermophilus) 		4 / 7 GLY A  60
LEU A 235
CYH A  45
ASP A   8
 None
None
None
ZN  A 301 ( 3.1A)
 0.81A 5hieB-3rqzA:
undetectable		 5hieB-3rqzA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_C_ACTC301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3rqz METALLOPHOSPHOESTERA
SE
(Sphaerobacter
thermophilus) 		5 / 6 ASP A  34
ASP A   8
HIS A  10
HIS A 149
HIS A 114
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.1A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.5A)
ZN  A 302 (-4.2A)
 1.08A 5ncdB-3rqzA:
undetectable
5ncdC-3rqzA:
undetectable		 5ncdB-3rqzA:
18.28
5ncdC-3rqzA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_D_ACTD301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3rqz METALLOPHOSPHOESTERA
SE
(Sphaerobacter
thermophilus) 		4 / 4 ASP A  34
HIS A 114
HIS A 147
HIS A  62
 ZN  A 301 ( 3.2A)
ZN  A 302 (-4.2A)
ZN  A 302 (-3.3A)
None
 1.47A 5ncdD-3rqzA:
undetectable		 5ncdD-3rqzA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_A_ACTA302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3rqz METALLOPHOSPHOESTERA
SE
(Sphaerobacter
thermophilus) 		5 / 6 ASP A  34
ASP A   8
HIS A  10
HIS A 149
HIS A 114
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.1A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.5A)
ZN  A 302 (-4.2A)
 1.05A 5nelA-3rqzA:
undetectable
5nelD-3rqzA:
undetectable		 5nelA-3rqzA:
18.28
5nelD-3rqzA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_C_ACTC302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3rqz METALLOPHOSPHOESTERA
SE
(Sphaerobacter
thermophilus) 		4 / 6 ASP A  34
HIS A  10
HIS A 149
HIS A 114
 ZN  A 301 ( 3.2A)
ZN  A 301 (-3.4A)
ZN  A 301 (-3.5A)
ZN  A 302 (-4.2A)
 0.95A 5nelB-3rqzA:
undetectable
5nelC-3rqzA:
undetectable		 5nelB-3rqzA:
18.28
5nelC-3rqzA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 3rqz METALLOPHOSPHOESTERA
SE
(Sphaerobacter
thermophilus) 		5 / 11 HIS A  10
HIS A 149
HIS A 147
HIS A 114
VAL A 113
 ZN  A 301 (-3.4A)
ZN  A 301 (-3.5A)
ZN  A 302 (-3.3A)
ZN  A 302 (-4.2A)
None
 1.21A 5z0fA-3rqzA:
undetectable
5z0fB-3rqzA:
undetectable		 5z0fA-3rqzA:
21.35
5z0fB-3rqzA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)		 3rqz METALLOPHOSPHOESTERA
SE
(Sphaerobacter
thermophilus) 		5 / 11 HIS A  10
HIS A 149
HIS A 147
HIS A 114
VAL A 113
 ZN  A 301 (-3.4A)
ZN  A 301 (-3.5A)
ZN  A 302 (-3.3A)
ZN  A 302 (-4.2A)
None
 1.19A 5z0gA-3rqzA:
undetectable
5z0gB-3rqzA:
undetectable		 5z0gA-3rqzA:
21.35
5z0gB-3rqzA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0H_B_DAHB98_0
(MELC
TYROSINASE)		 3rqz METALLOPHOSPHOESTERA
SE
(Sphaerobacter
thermophilus) 		5 / 11 HIS A  10
HIS A 149
HIS A 147
HIS A 114
VAL A 113
 ZN  A 301 (-3.4A)
ZN  A 301 (-3.5A)
ZN  A 302 (-3.3A)
ZN  A 302 (-4.2A)
None
 1.26A 5z0hA-3rqzA:
undetectable
5z0hB-3rqzA:
undetectable		 5z0hA-3rqzA:
21.35
5z0hB-3rqzA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0I_B_DAHB98_0
(MELC
TYROSINASE)		 3rqz METALLOPHOSPHOESTERA
SE
(Sphaerobacter
thermophilus) 		5 / 11 HIS A  10
HIS A 149
HIS A 147
HIS A 114
VAL A 113
 ZN  A 301 (-3.4A)
ZN  A 301 (-3.5A)
ZN  A 302 (-3.3A)
ZN  A 302 (-4.2A)
None
 1.23A 5z0iA-3rqzA:
undetectable
5z0iB-3rqzA:
undetectable		 5z0iA-3rqzA:
21.35
5z0iB-3rqzA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0J_B_DAHB98_0
(MELC
TYROSINASE)		 3rqz METALLOPHOSPHOESTERA
SE
(Sphaerobacter
thermophilus) 		5 / 11 HIS A  10
HIS A 149
HIS A 147
HIS A 114
VAL A 113
 ZN  A 301 (-3.4A)
ZN  A 301 (-3.5A)
ZN  A 302 (-3.3A)
ZN  A 302 (-4.2A)
None
 1.20A 5z0jA-3rqzA:
undetectable
5z0jB-3rqzA:
undetectable		 5z0jA-3rqzA:
21.35
5z0jB-3rqzA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0K_B_DAHB98_0
(MELC
TYROSINASE)		 3rqz METALLOPHOSPHOESTERA
SE
(Sphaerobacter
thermophilus) 		5 / 11 HIS A  10
HIS A 149
HIS A 147
HIS A 114
VAL A 113
 ZN  A 301 (-3.4A)
ZN  A 301 (-3.5A)
ZN  A 302 (-3.3A)
ZN  A 302 (-4.2A)
None
 1.21A 5z0kA-3rqzA:
undetectable
5z0kB-3rqzA:
undetectable		 5z0kA-3rqzA:
21.35
5z0kB-3rqzA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0L_B_DAHB98_0
(MELC
TYROSINASE)		 3rqz METALLOPHOSPHOESTERA
SE
(Sphaerobacter
thermophilus) 		5 / 11 HIS A  10
HIS A 149
HIS A 147
HIS A 114
VAL A 113
 ZN  A 301 (-3.4A)
ZN  A 301 (-3.5A)
ZN  A 302 (-3.3A)
ZN  A 302 (-4.2A)
None
 1.26A 5z0lA-3rqzA:
undetectable
5z0lB-3rqzA:
undetectable		 5z0lA-3rqzA:
21.35
5z0lB-3rqzA:
16.80