SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rr2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))		 3rr2 CYSTEINE SYNTHASE
(Mycobacterium
marinum) 		5 / 11 ARG A 193
GLU A 160
HIS A 154
ALA A 155
GLY A 181
 None
 1.09A 1cmaA-3rr2A:
undetectable
1cmaB-3rr2A:
undetectable		 1cmaA-3rr2A:
18.29
1cmaB-3rr2A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_A_SAMA200_0
(METHIONINE REPRESSOR)		 3rr2 CYSTEINE SYNTHASE
(Mycobacterium
marinum) 		5 / 11 ARG A 193
GLU A 160
HIS A 154
ALA A 155
GLY A 181
 None
 1.10A 1mjqA-3rr2A:
undetectable
1mjqB-3rr2A:
undetectable		 1mjqA-3rr2A:
17.89
1mjqB-3rr2A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OXR_A_AINA141_1
(PHOSPHOLIPASE A2
ISOFORM 3)		 3rr2 CYSTEINE SYNTHASE
(Mycobacterium
marinum) 		4 / 4 LEU A 105
GLY A  41
ASP A  45
TYR A 109
 None
 1.12A 1oxrA-3rr2A:
undetectable		 1oxrA-3rr2A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3rr2 CYSTEINE SYNTHASE
(Mycobacterium
marinum) 		5 / 12 ALA A  78
SER A  42
ASN A  74
GLY A  48
ILE A  47
 None
 1.21A 2dcfA-3rr2A:
undetectable		 2dcfA-3rr2A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)		 3rr2 CYSTEINE SYNTHASE
(Mycobacterium
marinum) 		5 / 10 HIS A 279
ALA A  28
ASN A 283
ALA A 284
ALA A  27
 None
 1.42A 2r2vC-3rr2A:
undetectable
2r2vF-3rr2A:
undetectable
2r2vG-3rr2A:
undetectable		 2r2vC-3rr2A:
9.40
2r2vF-3rr2A:
9.40
2r2vG-3rr2A:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3rr2 CYSTEINE SYNTHASE
(Mycobacterium
marinum) 		5 / 11 ALA A  78
SER A  42
ASN A  74
GLY A  48
ILE A  47
 None
 1.18A 2zmaA-3rr2A:
undetectable		 2zmaA-3rr2A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A65_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3rr2 CYSTEINE SYNTHASE
(Mycobacterium
marinum) 		5 / 12 ALA A  78
SER A  42
ASN A  74
GLY A  48
ILE A  47
 None
 1.23A 3a65A-3rr2A:
undetectable		 3a65A-3rr2A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A66_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3rr2 CYSTEINE SYNTHASE
(Mycobacterium
marinum) 		5 / 10 ALA A  78
SER A  42
ASN A  74
GLY A  48
ILE A  47
 None
 1.21A 3a66A-3rr2A:
0.0		 3a66A-3rr2A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_A_BEZA701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 3rr2 CYSTEINE SYNTHASE
(Mycobacterium
marinum) 		5 / 12 ILE A  11
GLY A  13
THR A  14
GLU A 161
THR A 157
 None
 1.34A 3r75A-3rr2A:
3.3		 3r75A-3rr2A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_B_BEZB701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 3rr2 CYSTEINE SYNTHASE
(Mycobacterium
marinum) 		5 / 12 ILE A  11
GLY A  13
THR A  14
GLU A 161
THR A 157
 None
 1.32A 3r75B-3rr2A:
3.4		 3r75B-3rr2A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R76_A_BEZA701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 3rr2 CYSTEINE SYNTHASE
(Mycobacterium
marinum) 		5 / 11 ILE A  11
GLY A  13
THR A  14
GLU A 161
THR A 157
 None
 1.33A 3r76A-3rr2A:
3.2		 3r76A-3rr2A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R76_A_BEZA701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 3rr2 CYSTEINE SYNTHASE
(Mycobacterium
marinum) 		5 / 11 ILE A  11
GLY A  13
THR A  14
GLU A 161
THR A 158
 None
 1.35A 3r76A-3rr2A:
3.2		 3r76A-3rr2A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R76_B_BEZB701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 3rr2 CYSTEINE SYNTHASE
(Mycobacterium
marinum) 		5 / 11 ILE A  11
GLY A  13
THR A  14
GLU A 161
THR A 157
 None
 1.36A 3r76B-3rr2A:
3.3		 3r76B-3rr2A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R76_B_BEZB701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 3rr2 CYSTEINE SYNTHASE
(Mycobacterium
marinum) 		5 / 11 ILE A  11
GLY A  13
THR A  14
GLU A 161
THR A 158
 None
 1.36A 3r76B-3rr2A:
3.3		 3r76B-3rr2A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWP_A_ACAA503_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3rr2 CYSTEINE SYNTHASE
(Mycobacterium
marinum) 		5 / 10 ALA A  78
SER A  42
ASN A  74
GLY A  48
ILE A  47
 None
 1.21A 3vwpA-3rr2A:
0.0		 3vwpA-3rr2A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWQ_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3rr2 CYSTEINE SYNTHASE
(Mycobacterium
marinum) 		5 / 12 ALA A  78
SER A  42
ASN A  74
GLY A  48
ILE A  47
 None
 1.21A 3vwqA-3rr2A:
undetectable		 3vwqA-3rr2A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWR_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3rr2 CYSTEINE SYNTHASE
(Mycobacterium
marinum) 		5 / 11 ALA A  78
SER A  42
ASN A  74
GLY A  48
ILE A  47
 None
 1.20A 3vwrA-3rr2A:
undetectable		 3vwrA-3rr2A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MTH_A_ACTA301_0
(ANTIBODY FAB HEAVY
CHAIN)		 3rr2 CYSTEINE SYNTHASE
(Mycobacterium
marinum) 		4 / 4 THR A 116
VAL A 114
PRO A  70
THR A  93
 None
 1.42A 5mthA-3rr2A:
undetectable
5mthH-3rr2A:
undetectable		 5mthA-3rr2A:
22.64
5mthH-3rr2A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSP_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3rr2 CYSTEINE SYNTHASE
(Mycobacterium
marinum) 		4 / 7 VAL A 177
ILE A 183
VAL A 240
ALA A 201
 None
 0.77A 5ospA-3rr2A:
undetectable		 5ospA-3rr2A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3rr2 CYSTEINE SYNTHASE
(Mycobacterium
marinum) 		4 / 7 VAL A 177
ILE A 183
VAL A 240
ALA A 201
 None
 0.76A 5osrA-3rr2A:
undetectable		 5osrA-3rr2A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3rr2 CYSTEINE SYNTHASE
(Mycobacterium
marinum) 		4 / 6 LEU A 292
VAL A 290
ARG A 275
VAL A  30
 None
 0.90A 5x7zA-3rr2A:
undetectable		 5x7zA-3rr2A:
19.94