SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rrk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2001_1
(SERUM ALBUMIN)		 3rrk V-TYPE ATPASE 116
KDA SUBUNIT
(Meiothermus
ruber) 		5 / 11 ARG A 260
TYR A 261
VAL A  55
ALA A  84
LEU A  81
 None
 1.20A 2bxgA-3rrkA:
2.5		 2bxgA-3rrkA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		 3rrk V-TYPE ATPASE 116
KDA SUBUNIT
(Meiothermus
ruber) 		3 / 3 MET A   1
VAL A   6
GLU A 289
 None
 0.84A 2x9gA-3rrkA:
undetectable		 2x9gA-3rrkA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP3_B_AICB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3rrk V-TYPE ATPASE 116
KDA SUBUNIT
(Meiothermus
ruber) 		3 / 3 ALA A 160
ARG A 162
LYS A 181
 None
None
NHE  A 520 (-3.2A)
 0.77A 3kp3B-3rrkA:
undetectable		 3kp3B-3rrkA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)		 3rrk V-TYPE ATPASE 116
KDA SUBUNIT
(Meiothermus
ruber) 		3 / 3 LYS A 262
LEU A  49
ALA A 265
 None
 0.81A 4iizA-3rrkA:
undetectable		 4iizA-3rrkA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADL_B_H4BB600_1
(ENDOTHELIAL NITRIC
OXIDE SYNTHASE)		 3rrk V-TYPE ATPASE 116
KDA SUBUNIT
(Meiothermus
ruber) 		4 / 7 GLU A 184
SER A 183
VAL A 180
ARG A 189
 None
None
NHE  A 520 ( 4.9A)
None
 1.36A 5adlA-3rrkA:
undetectable
5adlB-3rrkA:
undetectable		 5adlA-3rrkA:
23.40
5adlB-3rrkA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FJ3_B_H4BB600_1
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3rrk V-TYPE ATPASE 116
KDA SUBUNIT
(Meiothermus
ruber) 		4 / 7 GLU A 184
SER A 183
VAL A 180
ARG A 189
 None
None
NHE  A 520 ( 4.9A)
None
 1.37A 5fj3A-3rrkA:
undetectable
5fj3B-3rrkA:
3.6		 5fj3A-3rrkA:
23.40
5fj3B-3rrkA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECF_I_DVAI3010_0
(VLM2
DODECADEPSIPEPTIDE)		 3rrk V-TYPE ATPASE 116
KDA SUBUNIT
(Meiothermus
ruber) 		3 / 3 PHE A 163
ARG A 152
ALA A 176
 None
 0.94A 6ecfB-3rrkA:
undetectable		 6ecfB-3rrkA:
24.08