SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rrp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G60_A_SAMA500_0
(ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA)		 3rrp PROBABLE FUMARATE
HYDRATASE FUM
(Mycobacteroides
abscessus) 		5 / 12 ASN A 367
PHE A  97
GLY A 100
SER A 101
THR A 103
 None
None
None
LMR  A 468 (-2.9A)
LMR  A 468 (-2.9A)
 1.33A 1g60A-3rrpA:
undetectable		 1g60A-3rrpA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLF_A_NVPA999_1
(HIV-1 RT A-CHAIN
HIV-1 RT B-CHAIN)		 3rrp PROBABLE FUMARATE
HYDRATASE FUM
(Mycobacteroides
abscessus) 		5 / 8 LEU A 397
VAL A 193
GLY A 183
TRP A 176
GLU A 307
 None
 1.41A 1jlfA-3rrpA:
undetectable
1jlfB-3rrpA:
undetectable		 1jlfA-3rrpA:
21.95
1jlfB-3rrpA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LHU_A_ESTA301_1
(SEX HORMONE-BINDING
GLOBULIN)		 3rrp PROBABLE FUMARATE
HYDRATASE FUM
(Mycobacteroides
abscessus) 		5 / 12 ASN A 133
LEU A  51
LYS A  55
ILE A  94
LEU A  43
 None
 1.22A 1lhuA-3rrpA:
undetectable		 1lhuA-3rrpA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3rrp PROBABLE FUMARATE
HYDRATASE FUM
(Mycobacteroides
abscessus) 		3 / 3 SER A 299
GLY A 298
ARG A 184
 None
 0.61A 1t9wA-3rrpA:
undetectable		 1t9wA-3rrpA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		 3rrp PROBABLE FUMARATE
HYDRATASE FUM
(Mycobacteroides
abscessus) 		4 / 6 ASN A 133
ASN A 110
ILE A  83
THR A 141
 None
 1.20A 2hkkA-3rrpA:
undetectable		 2hkkA-3rrpA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)		 3rrp PROBABLE FUMARATE
HYDRATASE FUM
(Mycobacteroides
abscessus) 		5 / 12 GLY A 183
ASP A 458
ILE A 434
PRO A 410
LEU A 411
 None
 1.08A 3eeoA-3rrpA:
undetectable		 3eeoA-3rrpA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_A_BEZA701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 3rrp PROBABLE FUMARATE
HYDRATASE FUM
(Mycobacteroides
abscessus) 		5 / 12 ILE A 361
SER A 101
GLY A 100
SER A 104
THR A 103
 None
LMR  A 468 (-2.9A)
None
None
LMR  A 468 (-2.9A)
 1.15A 3r75A-3rrpA:
undetectable		 3r75A-3rrpA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R75_B_BEZB701_0
(ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I)		 3rrp PROBABLE FUMARATE
HYDRATASE FUM
(Mycobacteroides
abscessus) 		5 / 12 ILE A 361
SER A 101
GLY A 100
SER A 104
THR A 103
 None
LMR  A 468 (-2.9A)
None
None
LMR  A 468 (-2.9A)
 1.16A 3r75B-3rrpA:
undetectable		 3r75B-3rrpA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB802_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 3rrp PROBABLE FUMARATE
HYDRATASE FUM
(Mycobacteroides
abscessus) 		5 / 12 PHE A 240
SER A 263
SER A 137
CYH A  58
PRO A 237
 None
None
LMR  A 468 (-2.7A)
None
None
 1.39A 3v8vB-3rrpA:
undetectable		 3v8vB-3rrpA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3rrp PROBABLE FUMARATE
HYDRATASE FUM
(Mycobacteroides
abscessus) 		5 / 12 ILE A 290
ALA A 170
ILE A 308
LEU A 390
ILE A 294
 None
 0.98A 4kjjA-3rrpA:
undetectable		 4kjjA-3rrpA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 3rrp PROBABLE FUMARATE
HYDRATASE FUM
(Mycobacteroides
abscessus) 		5 / 11 GLY A 231
GLY A 227
GLY A 226
ALA A 229
GLN A 136
 None
 1.17A 4l8fB-3rrpA:
undetectable		 4l8fB-3rrpA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QCK_A_ASDA404_1
(3-KETOSTEROID-9-ALPH
A-MONOOXYGENASE
OXYGENASE SUBUNIT)		 3rrp PROBABLE FUMARATE
HYDRATASE FUM
(Mycobacteroides
abscessus) 		5 / 12 ASN A 133
VAL A 132
LEU A 248
ALA A  59
GLY A 226
 None
 1.30A 4qckA-3rrpA:
undetectable		 4qckA-3rrpA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3rrp PROBABLE FUMARATE
HYDRATASE FUM
(Mycobacteroides
abscessus) 		4 / 5 GLU A 370
THR A 373
THR A 146
LEU A  43
 None
 1.26A 5axaA-3rrpA:
undetectable		 5axaA-3rrpA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3rrp PROBABLE FUMARATE
HYDRATASE FUM
(Mycobacteroides
abscessus) 		4 / 5 GLU A 370
THR A 373
THR A 146
LEU A  43
 None
 1.28A 5axaC-3rrpA:
undetectable		 5axaC-3rrpA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_A_ADNA502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 3rrp PROBABLE FUMARATE
HYDRATASE FUM
(Mycobacteroides
abscessus) 		4 / 4 GLU A 370
THR A 373
THR A 146
LEU A  43
 None
 1.26A 5v96A-3rrpA:
undetectable		 5v96A-3rrpA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_B_ADNB502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 3rrp PROBABLE FUMARATE
HYDRATASE FUM
(Mycobacteroides
abscessus) 		4 / 4 GLU A 370
THR A 373
THR A 146
LEU A  43
 None
 1.26A 5v96B-3rrpA:
undetectable		 5v96B-3rrpA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_C_ADNC502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 3rrp PROBABLE FUMARATE
HYDRATASE FUM
(Mycobacteroides
abscessus) 		4 / 4 GLU A 370
THR A 373
THR A 146
LEU A  43
 None
 1.25A 5v96C-3rrpA:
undetectable		 5v96C-3rrpA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_D_ADND502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 3rrp PROBABLE FUMARATE
HYDRATASE FUM
(Mycobacteroides
abscessus) 		4 / 4 GLU A 370
THR A 373
THR A 146
LEU A  43
 None
 1.24A 5v96D-3rrpA:
undetectable		 5v96D-3rrpA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CGD_A_AKNA600_1
(BIFUNCTIONAL AAC/APH)		 3rrp PROBABLE FUMARATE
HYDRATASE FUM
(Mycobacteroides
abscessus) 		5 / 10 GLY A  40
GLU A 111
VAL A  17
GLU A  10
GLU A  34
 None
 1.44A 6cgdA-3rrpA:
undetectable		 6cgdA-3rrpA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 3rrp PROBABLE FUMARATE
HYDRATASE FUM
(Mycobacteroides
abscessus) 		5 / 10 LEU A 165
GLY A 209
ILE A 283
PHE A 382
ILE A 290
 None
 1.17A 6ebpC-3rrpA:
2.2		 6ebpC-3rrpA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		 3rrp PROBABLE FUMARATE
HYDRATASE FUM
(Mycobacteroides
abscessus) 		3 / 3 ASP A 262
ASP A 140
ASN A  62
 None
 0.84A 6gngB-3rrpA:
undetectable		 6gngB-3rrpA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3rrp PROBABLE FUMARATE
HYDRATASE FUM
(Mycobacteroides
abscessus) 		4 / 8 ASP A  89
ILE A  83
ARG A  45
ASN A 110
 None
 1.04A 6hisA-3rrpA:
undetectable
6hisB-3rrpA:
undetectable		 6hisA-3rrpA:
11.40
6hisB-3rrpA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3rrp PROBABLE FUMARATE
HYDRATASE FUM
(Mycobacteroides
abscessus) 		4 / 8 ASP A  89
ILE A  83
ARG A  45
ASN A 110
 None
 1.05A 6hisB-3rrpA:
undetectable
6hisC-3rrpA:
undetectable		 6hisB-3rrpA:
11.40
6hisC-3rrpA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3rrp PROBABLE FUMARATE
HYDRATASE FUM
(Mycobacteroides
abscessus) 		4 / 8 ASP A  89
ILE A  83
ARG A  45
ASN A 110
 None
 1.06A 6hisC-3rrpA:
undetectable
6hisD-3rrpA:
undetectable		 6hisC-3rrpA:
11.40
6hisD-3rrpA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3rrp PROBABLE FUMARATE
HYDRATASE FUM
(Mycobacteroides
abscessus) 		4 / 8 ASP A  89
ILE A  83
ARG A  45
ASN A 110
 None
 1.04A 6hisD-3rrpA:
1.9
6hisE-3rrpA:
undetectable		 6hisD-3rrpA:
11.40
6hisE-3rrpA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3rrp PROBABLE FUMARATE
HYDRATASE FUM
(Mycobacteroides
abscessus) 		4 / 8 ASN A 110
ASP A  89
ILE A  83
ARG A  45
 None
 1.06A 6hisA-3rrpA:
undetectable
6hisE-3rrpA:
undetectable		 6hisA-3rrpA:
11.40
6hisE-3rrpA:
11.40