SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rru'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1357_1
(PROSTAGLANDIN
REDUCTASE 2)		 3rru TOM1L1 PROTEIN
(Homo
sapiens) 		4 / 6 TYR A 143
LEU A 120
ASN A 121
ASP A  77
 None
 1.38A 2w98A-3rruA:
undetectable
2w98B-3rruA:
undetectable		 2w98A-3rruA:
18.99
2w98B-3rruA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_B_VD3B2001_1
(VITAMIN D
HYDROXYLASE)		 3rru TOM1L1 PROTEIN
(Homo
sapiens) 		5 / 11 THR A  23
ILE A  69
LEU A  56
LEU A  73
ILE A  76
 None
 1.32A 3a50B-3rruA:
undetectable		 3a50B-3rruA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		 3rru TOM1L1 PROTEIN
(Homo
sapiens) 		5 / 11 ILE A 119
ILE A  76
PHE A 122
ILE A 115
THR A  23
 None
 1.08A 3tmzA-3rruA:
undetectable		 3tmzA-3rruA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3rru TOM1L1 PROTEIN
(Homo
sapiens) 		4 / 4 GLY A 129
VAL A 134
PHE A  96
ILE A  91
 None
 1.05A 4xv2B-3rruA:
undetectable		 4xv2B-3rruA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_4_BEZ4801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3rru TOM1L1 PROTEIN
(Homo
sapiens) 		4 / 5 LEU A  75
PHE A  87
ILE A  76
ILE A  91
 None
 1.08A 5dzk4-3rruA:
undetectable
5dzkg-3rruA:
undetectable
5dzkm-3rruA:
undetectable
5dzkn-3rruA:
undetectable		 5dzk4-3rruA:
1.87
5dzkg-3rruA:
20.81
5dzkm-3rruA:
21.15
5dzkn-3rruA:
21.15