SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rrv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_B_ESTB2_1
(ESTROGEN RECEPTOR)		 3rrv ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacterium
avium) 		5 / 10 MET A   4
ALA A  39
GLU A  91
MET A  96
ARG A  98
 None
 1.45A 1pcgB-3rrvA:
undetectable		 1pcgB-3rrvA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I2Z_A_SALA1100_1
(SERUM ALBUMIN)		 3rrv ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacterium
avium) 		4 / 5 LEU A 118
LEU A  34
ILE A   8
ALA A  39
 None
 0.67A 2i2zA-3rrvA:
undetectable		 2i2zA-3rrvA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_A_SORA397_0
(D-XYLOSE ISOMERASE)		 3rrv ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacterium
avium) 		5 / 12 HIS A  35
THR A  85
GLU A 234
HIS A 137
ASP A 135
 None
None
CA  A 257 (-2.6A)
CA  A 257 (-3.3A)
None
 1.46A 2xinA-3rrvA:
undetectable		 2xinA-3rrvA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XIN_C_SORC397_0
(D-XYLOSE ISOMERASE)		 3rrv ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacterium
avium) 		5 / 12 HIS A  35
THR A  85
GLU A 234
HIS A 137
ASP A 135
 None
None
CA  A 257 (-2.6A)
CA  A 257 (-3.3A)
None
 1.49A 2xinC-3rrvA:
undetectable		 2xinC-3rrvA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_A_VDYA6178_1
(VITAMIN D
HYDROXYLASE)		 3rrv ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacterium
avium) 		5 / 11 ILE A  92
LEU A 114
THR A 151
VAL A 223
LEU A 227
 None
 1.16A 3a51A-3rrvA:
1.5		 3a51A-3rrvA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)		 3rrv ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacterium
avium) 		5 / 12 ILE A  92
LEU A 114
THR A 151
VAL A 223
LEU A 227
 None
 1.13A 3a51D-3rrvA:
undetectable		 3a51D-3rrvA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3rrv ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacterium
avium) 		5 / 9 LEU A 203
VAL A 208
VAL A 104
ILE A 101
VAL A 125
 None
 1.43A 3cs9C-3rrvA:
undetectable		 3cs9C-3rrvA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 3rrv ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacterium
avium) 		5 / 12 ILE A  86
ALA A 230
LEU A 150
GLU A  91
SER A 117
 None
 1.08A 3eigA-3rrvA:
undetectable		 3eigA-3rrvA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_B_ESTB600_1
(ESTROGEN RECEPTOR)		 3rrv ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacterium
avium) 		5 / 10 MET A   4
ALA A  39
GLU A  91
MET A  96
ARG A  98
 None
 1.50A 3uudB-3rrvA:
undetectable		 3uudB-3rrvA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_J_CHDJ103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3rrv ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacterium
avium) 		5 / 11 LEU A 114
LEU A 118
LEU A  38
GLU A   7
LEU A  21
 None
None
None
CA  A 256 (-2.8A)
None
 1.17A 4wg0J-3rrvA:
undetectable
4wg0K-3rrvA:
undetectable
4wg0L-3rrvA:
undetectable		 4wg0J-3rrvA:
4.36
4wg0K-3rrvA:
4.36
4wg0L-3rrvA:
4.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DX3_B_ESTB1000_1
(ESTROGEN RECEPTOR)		 3rrv ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacterium
avium) 		5 / 9 MET A   4
ALA A  39
GLU A  91
MET A  96
ARG A  98
 None
 1.46A 5dx3B-3rrvA:
undetectable		 5dx3B-3rrvA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_B_ESTB1000_1
(ESTROGEN RECEPTOR)		 3rrv ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacterium
avium) 		5 / 10 MET A   4
ALA A  39
GLU A  91
MET A  96
ARG A  98
 None
 1.48A 5dxeB-3rrvA:
undetectable		 5dxeB-3rrvA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 3rrv ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacterium
avium) 		5 / 8 GLY A  67
GLY A  66
VAL A 140
HIS A 137
ASP A 135
 None
None
None
CA  A 257 (-3.3A)
None
 1.47A 5f8yA-3rrvA:
undetectable		 5f8yA-3rrvA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB201_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 3rrv ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacterium
avium) 		5 / 8 GLY A  67
GLY A  66
VAL A 140
HIS A 137
ASP A 135
 None
None
None
CA  A 257 (-3.3A)
None
 1.43A 5f8yB-3rrvA:
undetectable		 5f8yB-3rrvA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 3rrv ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacterium
avium) 		5 / 9 GLY A  67
GLY A  66
VAL A 140
HIS A 137
ASP A 146
 None
None
None
CA  A 257 (-3.3A)
CA  A 257 (-2.7A)
 1.47A 5f8yB-3rrvA:
undetectable		 5f8yB-3rrvA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB203_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 3rrv ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacterium
avium) 		5 / 9 GLY A  67
GLY A  66
VAL A 140
HIS A 137
ASP A 135
 None
None
None
CA  A 257 (-3.3A)
None
 1.42A 5f8yB-3rrvA:
undetectable		 5f8yB-3rrvA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 3rrv ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacterium
avium) 		5 / 12 VAL A  30
ASP A  68
ASP A  88
SER A  64
ARG A  82
 None
 1.41A 5hnzB-3rrvA:
undetectable		 5hnzB-3rrvA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_B_ESTB601_1
(ESTROGEN RECEPTOR)		 3rrv ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacterium
avium) 		5 / 11 MET A   4
ALA A  39
GLU A  91
MET A  96
ARG A  98
 None
 1.48A 5hyrB-3rrvA:
undetectable		 5hyrB-3rrvA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 3rrv ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacterium
avium) 		5 / 7 VAL A  93
LEU A 121
GLU A  91
LEU A 227
LEU A 231
 None
 1.33A 5jq7A-3rrvA:
undetectable		 5jq7A-3rrvA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WGD_A_ESTA601_1
(ESTROGEN RECEPTOR)		 3rrv ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacterium
avium) 		5 / 9 MET A   4
ALA A  39
GLU A  91
MET A  96
ARG A  98
 None
 1.50A 5wgdA-3rrvA:
undetectable		 5wgdA-3rrvA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_0
(MRNA CAPPING ENZYME
P5)		 3rrv ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacterium
avium) 		5 / 12 LEU A 118
GLY A  58
ALA A 111
PRO A  24
THR A  20
 None
 1.34A 5x6yA-3rrvA:
undetectable		 5x6yA-3rrvA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC902_0
(MRNA CAPPING ENZYME
P5)		 3rrv ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacterium
avium) 		5 / 12 LEU A 118
GLY A  58
ALA A 111
PRO A  24
THR A  20
 None
 1.34A 5x6yC-3rrvA:
undetectable		 5x6yC-3rrvA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIM_A_SORA397_0
(D-XYLOSE ISOMERASE)		 3rrv ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacterium
avium) 		5 / 12 HIS A  35
THR A  85
GLU A 234
HIS A 137
ASP A 135
 None
None
CA  A 257 (-2.6A)
CA  A 257 (-3.3A)
None
 1.40A 5ximA-3rrvA:
undetectable		 5ximA-3rrvA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_C_RFPC502_1
(RIFAMPIN
MONOOXYGENASE)		 3rrv ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacterium
avium) 		5 / 12 VAL A 107
VAL A 119
GLY A 168
ARG A 170
GLY A  66
 None
 1.00A 6brdC-3rrvA:
undetectable		 6brdC-3rrvA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_B_ESTB602_1
(ESTROGEN RECEPTOR)		 3rrv ENOYL-COA
HYDRATASE/ISOMERASE
(Mycobacterium
avium) 		5 / 10 MET A   4
ALA A  39
GLU A  91
MET A  96
ARG A  98
 None
 1.47A 6cbzB-3rrvA:
undetectable		 6cbzB-3rrvA:
15.85