SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rrw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_1
(LIVER
CARBOXYLESTERASE I)
3rrw THYLAKOID LUMENAL 29
KDA PROTEIN,
CHLOROPLASTIC

(Arabidopsis
thaliana)
5 / 12 LEU A 235
VAL A 190
VAL A 181
LEU A 183
LEU A 245
None
1.14A 1mx1E-3rrwA:
undetectable
1mx1E-3rrwA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TBF_A_VIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
3rrw THYLAKOID LUMENAL 29
KDA PROTEIN,
CHLOROPLASTIC

(Arabidopsis
thaliana)
5 / 9 LEU A  40
LEU A 242
VAL A 190
LEU A 206
PHE A 178
None
1.28A 1tbfA-3rrwA:
undetectable
1tbfA-3rrwA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)
3rrw THYLAKOID LUMENAL 29
KDA PROTEIN,
CHLOROPLASTIC

(Arabidopsis
thaliana)
4 / 7 SER A 243
CYH A 244
GLN A  14
ILE A 249
None
1.00A 2xz5A-3rrwA:
undetectable
2xz5B-3rrwA:
undetectable
2xz5A-3rrwA:
21.03
2xz5B-3rrwA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)
3rrw THYLAKOID LUMENAL 29
KDA PROTEIN,
CHLOROPLASTIC

(Arabidopsis
thaliana)
4 / 8 SER A 243
CYH A 244
GLN A  14
ILE A 249
None
1.00A 2xz5B-3rrwA:
undetectable
2xz5E-3rrwA:
undetectable
2xz5B-3rrwA:
21.03
2xz5E-3rrwA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHZ_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)
3rrw THYLAKOID LUMENAL 29
KDA PROTEIN,
CHLOROPLASTIC

(Arabidopsis
thaliana)
4 / 8 PHE A 178
TRP A 166
GLY A  57
ILE A  59
None
0.81A 3ihzB-3rrwA:
undetectable
3ihzB-3rrwA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)
3rrw THYLAKOID LUMENAL 29
KDA PROTEIN,
CHLOROPLASTIC

(Arabidopsis
thaliana)
5 / 12 THR A 240
PHE A 149
GLY A 150
ALA A 105
GLY A 106
None
None
GOL  A 273 ( 4.2A)
None
None
1.15A 3v3oA-3rrwA:
undetectable
3v3oA-3rrwA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)
3rrw THYLAKOID LUMENAL 29
KDA PROTEIN,
CHLOROPLASTIC

(Arabidopsis
thaliana)
5 / 12 GLY A  57
ILE A  59
ILE A 102
SER A 152
ILE A 101
None
None
None
GOL  A 273 ( 4.5A)
None
0.99A 4ax8A-3rrwA:
undetectable
4ax8A-3rrwA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_D_ACTD1113_0
(BLR5658 PROTEIN)
3rrw THYLAKOID LUMENAL 29
KDA PROTEIN,
CHLOROPLASTIC

(Arabidopsis
thaliana)
4 / 4 TRP A 166
LEU A 188
LEU A 206
THR A 202
None
1.39A 4bboD-3rrwA:
undetectable
4bboD-3rrwA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA502_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)
3rrw THYLAKOID LUMENAL 29
KDA PROTEIN,
CHLOROPLASTIC

(Arabidopsis
thaliana)
4 / 8 LEU A 188
VAL A 212
VAL A 216
GLN A 220
None
0.63A 4em2A-3rrwA:
1.0
4em2A-3rrwA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)
3rrw THYLAKOID LUMENAL 29
KDA PROTEIN,
CHLOROPLASTIC

(Arabidopsis
thaliana)
4 / 7 PHE A 149
ASP A 100
SER A  97
ARG A  10
None
None
GOL  A 273 (-4.3A)
None
1.21A 4lv9A-3rrwA:
undetectable
4lv9B-3rrwA:
undetectable
4lv9A-3rrwA:
18.73
4lv9B-3rrwA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_B_ADNB302_1
(FLUORINASE)
3rrw THYLAKOID LUMENAL 29
KDA PROTEIN,
CHLOROPLASTIC

(Arabidopsis
thaliana)
4 / 6 ASP A 158
THR A  45
TYR A  46
SER A  52
CA  A 271 (-3.0A)
CA  A 271 (-4.0A)
None
None
1.41A 5b6iB-3rrwA:
undetectable
5b6iB-3rrwA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VYH_A_FOLA409_0
(S PROTEIN)
3rrw THYLAKOID LUMENAL 29
KDA PROTEIN,
CHLOROPLASTIC

(Arabidopsis
thaliana)
5 / 10 ARG A  60
ALA A 154
GLY A  54
THR A  45
ALA A 157
None
None
CA  A 271 (-4.4A)
CA  A 271 (-4.0A)
None
1.34A 5vyhA-3rrwA:
undetectable
5vyhA-3rrwA:
21.20