SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rsc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		 3rsc CALG2
(Micromonospora
echinospora) 		5 / 11 ALA A   2
LEU A 393
LEU A   4
LEU A 104
ALA A 386
 None
 1.08A 1h9zA-3rscA:
undetectable		 1h9zA-3rscA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		 3rsc CALG2
(Micromonospora
echinospora) 		5 / 11 ALA A   2
LEU A 393
LEU A   4
LEU A 104
ALA A 386
 None
 1.05A 1ha2A-3rscA:
undetectable		 1ha2A-3rscA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U1J_A_C2FA773_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 3rsc CALG2
(Micromonospora
echinospora) 		4 / 8 ARG A  45
HIS A   3
SER A  33
VAL A  52
 None
 1.29A 1u1jA-3rscA:
3.0		 1u1jA-3rscA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3rsc CALG2
(Micromonospora
echinospora) 		5 / 12 LEU A 185
LEU A 102
TYR A 392
ALA A 386
ALA A 383
 None
 1.19A 2bm9D-3rscA:
3.2		 2bm9D-3rscA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3rsc CALG2
(Micromonospora
echinospora) 		4 / 8 ILE A  15
TRP A 285
GLY A  39
GLY A  38
 None
None
PO4  A 401 (-3.5A)
PO4  A 401 ( 3.8A)
 0.81A 2qx4A-3rscA:
4.3
2qx4B-3rscA:
4.5		 2qx4A-3rscA:
21.48
2qx4B-3rscA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3rsc CALG2
(Micromonospora
echinospora) 		4 / 6 ILE A  15
TRP A 285
GLY A  39
GLY A  38
 None
None
PO4  A 401 (-3.5A)
PO4  A 401 ( 3.8A)
 0.81A 2qx6A-3rscA:
4.3
2qx6B-3rscA:
4.4		 2qx6A-3rscA:
21.48
2qx6B-3rscA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1100_1
(SERUM ALBUMIN)		 3rsc CALG2
(Micromonospora
echinospora) 		4 / 4 LEU A 104
ARG A 395
LEU A 393
ALA A 388
 None
 1.16A 3b9mA-3rscA:
undetectable		 3b9mA-3rscA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1100_1
(SERUM ALBUMIN)		 3rsc CALG2
(Micromonospora
echinospora) 		4 / 4 LEU A 276
ARG A 284
LEU A 264
ALA A 271
 None
 0.99A 3b9mA-3rscA:
undetectable		 3b9mA-3rscA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUR_B_TESB340_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 3rsc CALG2
(Micromonospora
echinospora) 		5 / 10 TYR A  80
ASN A 180
TRP A 179
VAL A 176
VAL A 175
 C0T  A 398 (-3.3A)
None
None
None
None
 1.44A 3burB-3rscA:
undetectable		 3burB-3rscA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CAS_A_ASDA332_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 3rsc CALG2
(Micromonospora
echinospora) 		5 / 10 TYR A  80
TRP A 179
VAL A 176
VAL A 175
LEU A 162
 C0T  A 398 (-3.3A)
None
None
None
None
 1.42A 3casA-3rscA:
undetectable		 3casA-3rscA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX95_0
(PROTEIN S100-B)		 3rsc CALG2
(Micromonospora
echinospora) 		3 / 3 CYH A 249
PHE A 246
PHE A 245
 None
 0.80A 3cr5X-3rscA:
undetectable		 3cr5X-3rscA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUV_B_ASDB126_1
(STEROID
DELTA-ISOMERASE)		 3rsc CALG2
(Micromonospora
echinospora) 		5 / 10 TYR A  80
LEU A  14
VAL A   9
ASN A  84
ALA A 112
 C0T  A 398 (-3.3A)
None
None
None
None
 1.42A 3nuvB-3rscA:
undetectable		 3nuvB-3rscA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_A_RTZA602_1
(CYTOCHROME P450 2D6)		 3rsc CALG2
(Micromonospora
echinospora) 		5 / 12 PHE A 245
GLY A 303
LEU A 307
VAL A 333
VAL A 297
 None
TYD  A 397 (-3.4A)
None
None
None
 1.18A 4wnwA-3rscA:
undetectable		 4wnwA-3rscA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_1
(CYTOCHROME P450 2D6)		 3rsc CALG2
(Micromonospora
echinospora) 		5 / 12 PHE A 245
GLY A 303
LEU A 307
VAL A 333
VAL A 297
 None
TYD  A 397 (-3.4A)
None
None
None
 1.06A 4wnwB-3rscA:
undetectable		 4wnwB-3rscA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XR4_B_AG2B511_1
(HOMOSPERMIDINE
SYNTHASE)		 3rsc CALG2
(Micromonospora
echinospora) 		3 / 3 VAL A 299
PHE A 246
ARG A 242
 None
None
PO4  A 399 (-3.7A)
 0.87A 4xr4B-3rscA:
6.5		 4xr4B-3rscA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_B_SAMB401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 3rsc CALG2
(Micromonospora
echinospora) 		5 / 12 LEU A 336
GLY A 337
VAL A 297
VAL A 359
ASP A 362
 None
 1.07A 6bxlB-3rscA:
2.8		 6bxlB-3rscA:
24.45