SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rsj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I1E_A_DM2A3001_1
(BOTULINUM NEUROTOXIN
TYPE B)		 3rsj BONT/F
(Clostridium
botulinum) 		6 / 9 GLU A1195
GLY A1239
HIS A1241
SER A1248
TRP A1250
TYR A1251
 NGA  A   3 ( 3.1A)
None
GAL  A   4 ( 4.2A)
GAL  A   4 (-2.7A)
GAL  A   4 (-4.1A)
GAL  A   4 ( 4.4A)
 0.70A 1i1eA-3rsjA:
28.6		 1i1eA-3rsjA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB503_1
(YKOF)		 3rsj BONT/F
(Clostridium
botulinum) 		4 / 7 SER A1021
ILE A 977
ILE A1023
THR A1014
 None
 0.99A 1sbrB-3rsjA:
undetectable		 1sbrB-3rsjA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3rsj BONT/F
(Clostridium
botulinum) 		4 / 7 GLN A 997
TYR A 995
TYR A 955
ILE A 957
 None
 1.13A 2ph9A-3rsjA:
undetectable
2ph9B-3rsjA:
undetectable		 2ph9A-3rsjA:
19.95
2ph9B-3rsjA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WB9_A_CYSA301_0
(GLUTATHIONE
TRANSFERASE SIGMA
CLASS)		 3rsj BONT/F
(Clostridium
botulinum) 		4 / 5 TYR A 900
GLY A 908
TYR A 910
TYR A1059
 None
 1.18A 2wb9A-3rsjA:
undetectable		 2wb9A-3rsjA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 3rsj BONT/F
(Clostridium
botulinum) 		5 / 12 ILE A 970
ILE A 958
ILE A 936
ILE A1009
PHE A1010
 None
 0.91A 2ygoA-3rsjA:
undetectable		 2ygoA-3rsjA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3rsj BONT/F
(Clostridium
botulinum) 		3 / 3 THR A1141
SER A1002
LYS A1007
 None
 1.19A 3aocC-3rsjA:
undetectable		 3aocC-3rsjA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3rsj BONT/F
(Clostridium
botulinum) 		4 / 4 ILE A1023
GLN A 989
ILE A 977
LEU A1038
 None
 1.34A 3dzyD-3rsjA:
undetectable		 3dzyD-3rsjA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1002_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 3rsj BONT/F
(Clostridium
botulinum) 		3 / 3 ASN A1108
TRP A1266
ASP A1113
 None
 1.31A 4a7tA-3rsjA:
undetectable
4a7tF-3rsjA:
undetectable		 4a7tA-3rsjA:
14.53
4a7tF-3rsjA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 3rsj BONT/F
(Clostridium
botulinum) 		5 / 12 ASN A 869
ILE A 866
ASP A1069
ILE A 925
GLY A 886
 None
 1.12A 4o1eA-3rsjA:
undetectable		 4o1eA-3rsjA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA601_1
(SERUM ALBUMIN)		 3rsj BONT/F
(Clostridium
botulinum) 		5 / 12 LEU A1048
PHE A 907
VAL A 897
GLY A 908
SER A 915
 None
 1.50A 4ot2A-3rsjA:
undetectable		 4ot2A-3rsjA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD4_C_AOQC4003_1
(CYTOCHROME B)		 3rsj BONT/F
(Clostridium
botulinum) 		6 / 12 GLY A1146
VAL A1147
ILE A1116
PHE A1122
LEU A1200
ILE A1197
 None
 1.38A 4pd4C-3rsjA:
undetectable		 4pd4C-3rsjA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		 3rsj BONT/F
(Clostridium
botulinum) 		3 / 3 LYS A1007
ILE A1009
ILE A1025
 None
 0.72A 4y0qA-3rsjA:
undetectable		 4y0qA-3rsjA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 3rsj BONT/F
(Clostridium
botulinum) 		3 / 3 ASP A 896
ASN A 894
PHE A1049
 None
 0.77A 5dsgB-3rsjA:
undetectable		 5dsgB-3rsjA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V37_A_SAMA504_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SMYD3)		 3rsj BONT/F
(Clostridium
botulinum) 		5 / 12 ARG A1017
GLY A1019
ASN A1020
GLU A1071
PHE A 934
 None
 1.48A 5v37A-3rsjA:
undetectable		 5v37A-3rsjA:
19.02