SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rtx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 3rtx MRNA-CAPPING ENZYME
(Mus
musculus) 		5 / 12 VAL A 241
GLY A 240
SER A 409
PHE A 232
VAL A 356
 None
 1.20A 1fduC-3rtxA:
undetectable		 1fduC-3rtxA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_A_ACTA1117_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3rtx MRNA-CAPPING ENZYME
(Mus
musculus) 		3 / 3 ASP A 314
ARG A 299
ARG A 315
 None
GUN  A   1 (-3.8A)
None
 0.96A 2j9dA-3rtxA:
undetectable
2j9dC-3rtxA:
undetectable		 2j9dA-3rtxA:
15.82
2j9dC-3rtxA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_1
(WNT INHIBITORY
FACTOR 1)		 3rtx MRNA-CAPPING ENZYME
(Mus
musculus) 		4 / 5 ILE A 441
PRO A 273
VAL A 322
PHE A 268
 None
GUN  A   1 (-4.6A)
None
None
 1.27A 2ygnA-3rtxA:
undetectable		 2ygnA-3rtxA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_A_DXCA91_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3rtx MRNA-CAPPING ENZYME
(Mus
musculus) 		3 / 3 PHE A 367
GLN A 382
PHE A 329
 None
 0.83A 3rv5A-3rtxA:
undetectable		 3rv5A-3rtxA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_1
(NS3 PROTEASE)		 3rtx MRNA-CAPPING ENZYME
(Mus
musculus) 		5 / 9 PHE A 320
ILE A 304
LEU A 303
ARG A 299
ASP A 343
 None
None
None
GUN  A   1 (-3.8A)
GUN  A   1 (-3.3A)
 1.08A 6c2mC-3rtxA:
undetectable		 6c2mC-3rtxA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NCS_A_ACTA303_0
(N-ACETYLNEURAMINIC
ACID (SIALIC ACID)
SYNTHETASE)		 3rtx MRNA-CAPPING ENZYME
(Mus
musculus) 		3 / 3 ILE A 236
THR A 237
PRO A 357
 None
 0.60A 6ncsA-3rtxA:
undetectable		 6ncsA-3rtxA:
20.17