SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ru6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_0
(ALCOHOL
DEHYDROGENASE)		 3ru6 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Campylobacter
jejuni) 		3 / 3 MET A  98
LEU A 101
SER A 102
 None
 0.63A 1ee2A-3ru6A:
undetectable		 1ee2A-3ru6A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 3ru6 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Campylobacter
jejuni) 		4 / 7 TYR A 128
ALA A  87
SER A  88
SER A 114
 None
 1.05A 2i91A-3ru6A:
undetectable		 2i91A-3ru6A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 3ru6 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Campylobacter
jejuni) 		4 / 7 TYR A 128
ALA A  87
SER A  88
SER A 114
 None
 1.05A 2i91B-3ru6A:
undetectable		 2i91B-3ru6A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_1
(PROTEASE)		 3ru6 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Campylobacter
jejuni) 		5 / 12 LEU A  78
GLY A  40
GLY A  32
VAL A  80
ILE A  44
 None
 0.90A 2ienA-3ru6A:
undetectable		 2ienA-3ru6A:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B302_2
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 3ru6 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Campylobacter
jejuni) 		3 / 3 CYH A   4
PRO A 174
ASP A  58
 None
 0.95A 3hlwB-3ru6A:
undetectable		 3hlwB-3ru6A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 3ru6 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Campylobacter
jejuni) 		5 / 10 PRO A 178
LEU A   3
ILE A 209
PRO A 208
GLY A 206
 IOD  A 287 ( 4.1A)
None
None
IOD  A 282 ( 4.1A)
IOD  A 284 ( 4.5A)
 1.19A 3ijxB-3ru6A:
undetectable
3ijxD-3ru6A:
undetectable		 3ijxB-3ru6A:
21.63
3ijxD-3ru6A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		 3ru6 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Campylobacter
jejuni) 		5 / 10 PRO A 178
LEU A   3
ILE A 209
PRO A 208
GLY A 206
 IOD  A 287 ( 4.1A)
None
None
IOD  A 282 ( 4.1A)
IOD  A 284 ( 4.5A)
 1.24A 3iluB-3ru6A:
undetectable
3iluE-3ru6A:
undetectable		 3iluB-3ru6A:
21.63
3iluE-3ru6A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		 3ru6 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Campylobacter
jejuni) 		5 / 11 ILE A 209
PRO A 208
GLY A 206
PRO A 178
LEU A   3
 None
IOD  A 282 ( 4.1A)
IOD  A 284 ( 4.5A)
IOD  A 287 ( 4.1A)
None
 1.24A 3iluB-3ru6A:
undetectable
3iluE-3ru6A:
undetectable		 3iluB-3ru6A:
21.63
3iluE-3ru6A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 3ru6 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Campylobacter
jejuni) 		5 / 12 LEU A 116
PHE A  61
ILE A  55
LEU A 172
VAL A 152
 IOD  A 285 ( 4.8A)
None
None
None
None
 1.25A 3sp9A-3ru6A:
undetectable		 3sp9A-3ru6A:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 3ru6 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Campylobacter
jejuni) 		5 / 12 LEU A 116
PHE A  61
ILE A  55
LEU A 172
VAL A 152
 IOD  A 285 ( 4.8A)
None
None
None
None
 1.23A 3sp9B-3ru6A:
undetectable		 3sp9B-3ru6A:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_A_ADNA501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 3ru6 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Campylobacter
jejuni) 		3 / 3 PRO A 178
LEU A 192
HIS A 227
 IOD  A 287 ( 4.1A)
None
None
 0.68A 4pevA-3ru6A:
undetectable		 4pevA-3ru6A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM5_A_CE3A301_2
(BETA-LACTAMASE
CTX-M-14)		 3ru6 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Campylobacter
jejuni) 		3 / 3 CYH A   4
PRO A 174
ASP A  58
 None
 0.97A 4pm5A-3ru6A:
undetectable		 4pm5A-3ru6A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_2
(BIFUNCTIONAL AAC/APH)		 3ru6 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Campylobacter
jejuni) 		3 / 3 LEU A 170
ASP A 201
TYR A 202
 None
 0.66A 4qc6B-3ru6A:
undetectable		 4qc6B-3ru6A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3ru6 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Campylobacter
jejuni) 		4 / 8 SER A  88
ALA A  87
HIS A  62
LEU A 116
 None
None
None
IOD  A 285 ( 4.8A)
 1.09A 5dzkd-3ru6A:
3.0
5dzkr-3ru6A:
undetectable		 5dzkd-3ru6A:
20.75
5dzkr-3ru6A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3ru6 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Campylobacter
jejuni) 		5 / 11 ILE A 222
ARG A 196
LEU A 192
VAL A   5
LEU A  25
 None
 1.24A 5ji0A-3ru6A:
undetectable		 5ji0A-3ru6A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		 3ru6 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Campylobacter
jejuni) 		4 / 8 LEU A  59
VAL A  31
LEU A  78
ILE A  55
 None
 0.93A 5v0vA-3ru6A:
undetectable		 5v0vA-3ru6A:
19.86