SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ru8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_1
(TRANSTHYRETIN)		 3ru8 EPITOPE SCAFFOLD
2BODX43
(Human
immunodeficiency
virus;
Thermobifida
fusca;
synthetic
construct) 		4 / 6 LYS X 190
ALA X 189
SER X 148
THR X 174
 None
 1.07A 1ictB-3ru8X:
undetectable		 1ictB-3ru8X:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_2
(TRANSTHYRETIN)		 3ru8 ANTIBODY B12, LIGHT
CHAIN
(Homo
sapiens) 		4 / 7 LEU L 136
THR L 173
SER L 163
THR L 165
 None
None
GOL  L 217 ( 3.7A)
None
 0.71A 1ictD-3ru8L:
3.9		 1ictD-3ru8L:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_A_9CRA131_1
(TRANSTHYRETIN)		 3ru8 EPITOPE SCAFFOLD
2BODX43
(Human
immunodeficiency
virus;
Thermobifida
fusca;
synthetic
construct) 		4 / 6 LYS X 190
ALA X 189
SER X 148
THR X 174
 None
 1.08A 1tyrA-3ru8X:
undetectable		 1tyrA-3ru8X:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3ru8 ANTIBODY B12, LIGHT
CHAIN
(Homo
sapiens) 		4 / 5 LEU L 180
GLY L 129
PRO L 121
VAL L 133
 None
 0.81A 2aojA-3ru8L:
undetectable		 2aojA-3ru8L:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 3ru8 EPITOPE SCAFFOLD
2BODX43
(Thermobifida
fusca;
Human
immunodeficiency
virus;
synthetic
construct) 		3 / 3 ASP X 144
ASP X 206
ASP X  72
 GOL  X 283 (-3.3A)
None
None
 0.57A 2igtA-3ru8X:
undetectable		 2igtA-3ru8X:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 3ru8 EPITOPE SCAFFOLD
2BODX43
(Thermobifida
fusca;
Human
immunodeficiency
virus;
synthetic
construct) 		3 / 3 ASP X 144
ASP X 206
ASP X  72
 GOL  X 283 (-3.3A)
None
None
 0.59A 2igtB-3ru8X:
2.1		 2igtB-3ru8X:
23.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 3ru8 ANTIBODY B12, LIGHT
CHAIN
(Homo
sapiens) 		4 / 7 TYR L  37
HIS L  39
PRO L  45
TYR L  88
 None
 0.34A 2oldA-3ru8L:
16.1
2oldB-3ru8L:
15.9		 2oldA-3ru8L:
44.93
2oldB-3ru8L:
44.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OMB_D_IPHD2002_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 3ru8 ANTIBODY B12, LIGHT
CHAIN
(Homo
sapiens) 		4 / 7 TYR L  37
HIS L  39
PRO L  45
TYR L  88
 None
 0.34A 2ombC-3ru8L:
18.1
2ombD-3ru8L:
20.2		 2ombC-3ru8L:
44.93
2ombD-3ru8L:
44.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_B_BEZB143_0
(PUTATIVE REDOX
PROTEIN)		 3ru8 EPITOPE SCAFFOLD
2BODX43
(Thermobifida
fusca;
Human
immunodeficiency
virus;
synthetic
construct) 		4 / 6 ARG X 162
THR X 124
ALA X 126
PRO X  75
 None
 1.23A 2ql8A-3ru8X:
undetectable
2ql8B-3ru8X:
undetectable		 2ql8A-3ru8X:
19.33
2ql8B-3ru8X:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 3ru8 EPITOPE SCAFFOLD
2BODX43
(Human
immunodeficiency
virus;
Thermobifida
fusca;
synthetic
construct) 		5 / 12 VAL X  70
SER X 208
ASN X 178
GLY X 146
ALA X 173
 None
None
None
GOL  X 283 (-3.3A)
None
 1.18A 2x2iC-3ru8X:
3.5		 2x2iC-3ru8X:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_A_DIFA1_1
(TRANSTHYRETIN)		 3ru8 EPITOPE SCAFFOLD
2BODX43
(Human
immunodeficiency
virus;
Thermobifida
fusca;
synthetic
construct) 		4 / 6 LYS X 190
ALA X 189
SER X 148
THR X 174
 None
 0.99A 3cfqA-3ru8X:
undetectable		 3cfqA-3ru8X:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3ru8 EPITOPE SCAFFOLD
2BODX43
(Thermobifida
fusca;
Human
immunodeficiency
virus;
synthetic
construct) 		5 / 12 LEU X 244
ILE X 105
ILE X 141
ARG X 100
ALA X 102
 None
 1.18A 3uj7A-3ru8X:
undetectable		 3uj7A-3ru8X:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_A_1FLA201_1
(TRANSTHYRETIN)		 3ru8 EPITOPE SCAFFOLD
2BODX43
(Human
immunodeficiency
virus;
Thermobifida
fusca;
synthetic
construct) 		4 / 6 LYS X 190
ALA X 189
SER X 148
THR X 174
 None
 1.05A 4i89A-3ru8X:
undetectable		 4i89A-3ru8X:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_B_1FLB201_1
(TRANSTHYRETIN)		 3ru8 EPITOPE SCAFFOLD
2BODX43
(Human
immunodeficiency
virus;
Thermobifida
fusca;
synthetic
construct) 		4 / 4 LYS X 190
ALA X 189
SER X 148
THR X 174
 None
 1.25A 4i89B-3ru8X:
undetectable		 4i89B-3ru8X:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1W_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3ru8 EPITOPE SCAFFOLD
2BODX43
(Human
immunodeficiency
virus;
Thermobifida
fusca;
synthetic
construct) 		4 / 6 VAL X 106
VAL X  73
ILE X  90
LEU X  97
 None
 0.98A 4l1wB-3ru8X:
3.9		 4l1wB-3ru8X:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_B_SAMB601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 3ru8 EPITOPE SCAFFOLD
2BODX43
(Thermobifida
fusca;
Human
immunodeficiency
virus;
synthetic
construct) 		5 / 12 GLY X 129
SER X 136
ILE X  90
VAL X 106
VAL X  71
 None
 1.13A 5dpdB-3ru8X:
undetectable		 5dpdB-3ru8X:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3ru8 EPITOPE SCAFFOLD
2BODX43
(Human
immunodeficiency
virus;
Thermobifida
fusca;
synthetic
construct) 		4 / 6 LYS X 247
ARG X 209
GLY X 254
ASP X 221
 GOL  X 284 (-2.9A)
None
None
None
 1.23A 5hp1A-3ru8X:
undetectable		 5hp1A-3ru8X:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3ru8 EPITOPE SCAFFOLD
2BODX43
(Human
immunodeficiency
virus;
Thermobifida
fusca;
synthetic
construct) 		3 / 3 SER X 148
LEU X 160
MET X 156
 None
None
GOL  X 283 (-4.4A)
 0.77A 5ikrB-3ru8X:
undetectable		 5ikrB-3ru8X:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 3ru8 EPITOPE SCAFFOLD
2BODX43
(Thermobifida
fusca;
Human
immunodeficiency
virus;
synthetic
construct) 		4 / 5 ASP X 253
ILE X 246
ASN X 217
TYR X 179
 None
 1.02A 6a93B-3ru8X:
undetectable		 6a93B-3ru8X:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA819_0
(GEPHYRIN)		 3ru8 ANTIBODY B12, LIGHT
CHAIN
(Homo
sapiens) 		3 / 3 ARG L  78
GLY L  16
GLU L  17
 None
 0.25A 6fgdA-3ru8L:
undetectable		 6fgdA-3ru8L:
19.42