SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ruc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_B_DVAB8_0
(GRAMICIDIN A)		 3ruc WBGU
(Plesiomonas
shigelloides) 		3 / 3 VAL A  43
VAL A  92
TRP A  19
 None
 0.97A 1av2A-3rucA:
undetectable
1av2B-3rucA:
undetectable		 1av2A-3rucA:
3.45
1av2B-3rucA:
3.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3ruc WBGU
(Plesiomonas
shigelloides) 		5 / 10 THR A 269
PHE A 236
ASN A 272
VAL A 224
TYR A 295
 None
 1.15A 1claA-3rucA:
undetectable		 1claA-3rucA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 3ruc WBGU
(Plesiomonas
shigelloides) 		4 / 7 HIS A  53
GLY A  52
ALA A  25
GLU A  59
 None
NAD  A 343 (-3.0A)
NAD  A 343 (-4.3A)
None
 0.74A 1dmaA-3rucA:
undetectable		 1dmaA-3rucA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 3ruc WBGU
(Plesiomonas
shigelloides) 		4 / 6 ASN A 118
HIS A  97
ALA A 100
GLY A 102
 None
None
NAD  A 343 (-3.3A)
UD2  A 344 ( 3.9A)
 1.14A 1l7xA-3rucA:
2.5		 1l7xA-3rucA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3ruc WBGU
(Plesiomonas
shigelloides) 		4 / 5 GLY A 190
ILE A 189
VAL A 263
SER A 249
 None
 1.14A 1rs7A-3rucA:
undetectable		 1rs7A-3rucA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 3ruc WBGU
(Plesiomonas
shigelloides) 		4 / 8 VAL A  24
TRP A  19
ILE A 125
GLY A  45
 None
 0.91A 2gssA-3rucA:
undetectable		 2gssA-3rucA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 3ruc WBGU
(Plesiomonas
shigelloides) 		4 / 8 VAL A  24
TRP A  19
ILE A 125
GLY A  45
 None
 0.91A 2gssB-3rucA:
undetectable		 2gssB-3rucA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3ruc WBGU
(Plesiomonas
shigelloides) 		4 / 6 GLY A  29
GLY A  52
PHE A  74
PHE A  72
 None
NAD  A 343 (-3.0A)
None
None
 1.03A 2qx6A-3rucA:
5.3
2qx6B-3rucA:
6.0		 2qx6A-3rucA:
20.85
2qx6B-3rucA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)		 3ruc WBGU
(Plesiomonas
shigelloides) 		5 / 11 ALA A 264
ILE A 211
PRO A 212
LEU A 274
ILE A 325
 None
 0.83A 3clbA-3rucA:
undetectable		 3clbA-3rucA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_C_TMQC613_1
(DHFR-TS)		 3ruc WBGU
(Plesiomonas
shigelloides) 		5 / 12 ALA A 264
ILE A 211
PRO A 212
LEU A 274
ILE A 325
 None
 0.79A 3clbC-3rucA:
undetectable		 3clbC-3rucA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 3ruc WBGU
(Plesiomonas
shigelloides) 		5 / 12 ILE A  28
VAL A 242
ILE A 247
LEU A  33
ARG A 200
 NAD  A 343 (-3.8A)
None
None
None
None
 1.17A 3fpjB-3rucA:
6.5		 3fpjB-3rucA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)		 3ruc WBGU
(Plesiomonas
shigelloides) 		3 / 3 MET A 245
CYH A 237
PRO A 321
 None
 1.21A 3h52C-3rucA:
1.0		 3h52C-3rucA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_A_TMQA611_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3ruc WBGU
(Plesiomonas
shigelloides) 		5 / 10 ALA A 264
ILE A 211
PRO A 212
LEU A 274
ILE A 325
 None
 0.81A 3hbbA-3rucA:
undetectable		 3hbbA-3rucA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3ruc WBGU
(Plesiomonas
shigelloides) 		5 / 11 ALA A 264
ILE A 211
PRO A 212
LEU A 274
ILE A 325
 None
 0.83A 3hbbC-3rucA:
undetectable		 3hbbC-3rucA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_A_EAAA222_1
(GLUTATHIONE
S-TRANSFERASE P)		 3ruc WBGU
(Plesiomonas
shigelloides) 		5 / 10 VAL A  24
GLY A  23
TRP A  19
ILE A 125
GLY A  45
 None
NAD  A 343 (-3.3A)
None
None
None
 1.14A 3km6A-3rucA:
undetectable		 3km6A-3rucA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_A_EAAA210_1
(GLUTATHIONE
S-TRANSFERASE P)		 3ruc WBGU
(Plesiomonas
shigelloides) 		4 / 8 VAL A  24
TRP A  19
ILE A 125
GLY A  45
 None
 0.90A 3n9jA-3rucA:
undetectable		 3n9jA-3rucA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_A_PFLA319_1
(GLR4197 PROTEIN)		 3ruc WBGU
(Plesiomonas
shigelloides) 		4 / 7 ILE A 260
TYR A 171
THR A 145
ILE A 159
 None
 0.95A 3p50A-3rucA:
undetectable		 3p50A-3rucA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_B_PFLB319_1
(GLR4197 PROTEIN)		 3ruc WBGU
(Plesiomonas
shigelloides) 		4 / 7 ILE A 260
TYR A 171
THR A 145
ILE A 159
 None
 0.96A 3p50B-3rucA:
undetectable		 3p50B-3rucA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_C_PFLC319_1
(GLR4197 PROTEIN)		 3ruc WBGU
(Plesiomonas
shigelloides) 		4 / 7 ILE A 260
TYR A 171
THR A 145
ILE A 159
 None
 0.95A 3p50C-3rucA:
undetectable		 3p50C-3rucA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_D_PFLD320_1
(GLR4197 PROTEIN)		 3ruc WBGU
(Plesiomonas
shigelloides) 		4 / 7 ILE A 260
TYR A 171
THR A 145
ILE A 159
 None
 0.96A 3p50D-3rucA:
undetectable		 3p50D-3rucA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_E_PFLE319_1
(GLR4197 PROTEIN)		 3ruc WBGU
(Plesiomonas
shigelloides) 		4 / 7 ILE A 260
TYR A 171
THR A 145
ILE A 159
 None
 0.96A 3p50E-3rucA:
undetectable		 3p50E-3rucA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHN_A_ACTA108_0
(PROTEIN P-30)		 3ruc WBGU
(Plesiomonas
shigelloides) 		3 / 3 THR A 232
SER A 233
ARG A 234
 UD2  A 344 (-3.6A)
None
UD2  A 344 (-3.6A)
 0.77A 3phnA-3rucA:
undetectable		 3phnA-3rucA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_2
(HIV-1 PROTEASE)		 3ruc WBGU
(Plesiomonas
shigelloides) 		5 / 10 VAL A 172
ILE A 119
GLY A 121
ILE A 125
ALA A 177
 None
 0.91A 3t3cB-3rucA:
undetectable		 3t3cB-3rucA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3ruc WBGU
(Plesiomonas
shigelloides) 		4 / 7 TYR A 336
VAL A 337
ILE A 285
GLU A  59
 None
 1.11A 4a97E-3rucA:
undetectable		 4a97E-3rucA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_A_NCAA1536_0
(DIPHTHERIA TOXIN)		 3ruc WBGU
(Plesiomonas
shigelloides) 		4 / 6 HIS A  53
GLY A  52
ALA A  25
GLU A  59
 None
NAD  A 343 (-3.0A)
NAD  A 343 (-4.3A)
None
 0.76A 4ae1A-3rucA:
undetectable		 4ae1A-3rucA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3ruc WBGU
(Plesiomonas
shigelloides) 		4 / 5 GLY A 190
ILE A 189
VAL A 263
SER A 249
 None
 1.12A 4d33A-3rucA:
undetectable		 4d33A-3rucA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3ruc WBGU
(Plesiomonas
shigelloides) 		4 / 5 GLY A 190
ILE A 189
VAL A 263
SER A 249
 None
 1.08A 4d33B-3rucA:
undetectable		 4d33B-3rucA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 3ruc WBGU
(Plesiomonas
shigelloides) 		4 / 6 GLY A 190
ILE A 189
VAL A 263
SER A 249
 None
 1.07A 4d39B-3rucA:
undetectable		 4d39B-3rucA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		 3ruc WBGU
(Plesiomonas
shigelloides) 		5 / 12 SER A 332
LEU A 329
TYR A 238
GLN A 201
ASP A 235
 None
None
None
NAD  A 343 ( 4.8A)
None
 1.49A 4j7xF-3rucA:
6.5		 4j7xF-3rucA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		 3ruc WBGU
(Plesiomonas
shigelloides) 		5 / 12 SER A 332
LEU A 329
TYR A 238
GLN A 201
ASP A 235
 None
None
None
NAD  A 343 ( 4.8A)
None
 1.48A 4j7xJ-3rucA:
16.7		 4j7xJ-3rucA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 3ruc WBGU
(Plesiomonas
shigelloides) 		4 / 7 TYR A 193
GLN A  41
THR A  18
THR A 188
 NAD  A 343 ( 4.6A)
None
None
None
 1.05A 4mbsA-3rucA:
undetectable		 4mbsA-3rucA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNU_A_BEZA319_0
(SHKAI2IB)		 3ruc WBGU
(Plesiomonas
shigelloides) 		4 / 5 GLN A  98
ILE A  28
ILE A 243
TYR A 193
 None
NAD  A 343 (-3.8A)
None
NAD  A 343 ( 4.6A)
 1.27A 5dnuA-3rucA:
4.8		 5dnuA-3rucA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNV_A_BEZA304_0
(SHKAI2IB)		 3ruc WBGU
(Plesiomonas
shigelloides) 		4 / 5 GLN A  98
ILE A  28
ILE A 243
TYR A 193
 None
NAD  A 343 (-3.8A)
None
NAD  A 343 ( 4.6A)
 1.27A 5dnvA-3rucA:
5.1		 5dnvA-3rucA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_A_HISA402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 3ruc WBGU
(Plesiomonas
shigelloides) 		5 / 10 GLY A  45
THR A  18
VAL A  42
CYH A  73
VAL A  92
 None
 1.04A 6czmA-3rucA:
undetectable
6czmC-3rucA:
undetectable		 6czmA-3rucA:
23.86
6czmC-3rucA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_E_HISE402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 3ruc WBGU
(Plesiomonas
shigelloides) 		5 / 9 VAL A  92
GLY A  45
THR A  18
VAL A  42
CYH A  73
 None
 1.01A 6czmD-3rucA:
undetectable
6czmE-3rucA:
undetectable		 6czmD-3rucA:
23.86
6czmE-3rucA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_F_HISF402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 3ruc WBGU
(Plesiomonas
shigelloides) 		5 / 10 VAL A  92
GLY A  45
THR A  18
VAL A  42
CYH A  73
 None
 1.03A 6czmE-3rucA:
undetectable
6czmF-3rucA:
undetectable		 6czmE-3rucA:
23.86
6czmF-3rucA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_A_CXQA507_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 3ruc WBGU
(Plesiomonas
shigelloides) 		4 / 5 ARG A 192
ALA A 141
TYR A 139
ILE A 189
 None
 1.25A 6f6sA-3rucA:
0.3
6f6sB-3rucA:
undetectable		 6f6sA-3rucA:
14.84
6f6sB-3rucA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3ruc WBGU
(Plesiomonas
shigelloides) 		4 / 8 ASP A  78
ILE A  79
ARG A  80
ASN A 173
 NAD  A 343 (-3.1A)
NAD  A 343 (-4.0A)
NAD  A 343 ( 4.7A)
None
 1.21A 6hisA-3rucA:
undetectable
6hisB-3rucA:
undetectable		 6hisA-3rucA:
17.61
6hisB-3rucA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3ruc WBGU
(Plesiomonas
shigelloides) 		4 / 8 ASP A  78
ILE A  79
ARG A  80
ASN A 173
 NAD  A 343 (-3.1A)
NAD  A 343 (-4.0A)
NAD  A 343 ( 4.7A)
None
 1.21A 6hisB-3rucA:
undetectable
6hisC-3rucA:
undetectable		 6hisB-3rucA:
17.61
6hisC-3rucA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3ruc WBGU
(Plesiomonas
shigelloides) 		4 / 8 ASP A  78
ILE A  79
ARG A  80
ASN A 173
 NAD  A 343 (-3.1A)
NAD  A 343 (-4.0A)
NAD  A 343 ( 4.7A)
None
 1.20A 6hisC-3rucA:
undetectable
6hisD-3rucA:
undetectable		 6hisC-3rucA:
17.61
6hisD-3rucA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3ruc WBGU
(Plesiomonas
shigelloides) 		4 / 8 ASP A  78
ILE A  79
ARG A  80
ASN A 173
 NAD  A 343 (-3.1A)
NAD  A 343 (-4.0A)
NAD  A 343 ( 4.7A)
None
 1.20A 6hisD-3rucA:
undetectable
6hisE-3rucA:
undetectable		 6hisD-3rucA:
17.61
6hisE-3rucA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3ruc WBGU
(Plesiomonas
shigelloides) 		4 / 8 ASN A 173
ASP A  78
ILE A  79
ARG A  80
 None
NAD  A 343 (-3.1A)
NAD  A 343 (-4.0A)
NAD  A 343 ( 4.7A)
 1.20A 6hisA-3rucA:
undetectable
6hisE-3rucA:
undetectable		 6hisA-3rucA:
17.61
6hisE-3rucA:
17.61