SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ruy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_A_EAAA223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 3ruy ORNITHINE
AMINOTRANSFERASE
(Bacillus
anthracis) 		4 / 8 PHE A 239
GLY A 233
ARG A 234
LEU A 377
 None
 0.88A 1gsfA-3ruyA:
undetectable		 1gsfA-3ruyA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_B_EAAB223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 3ruy ORNITHINE
AMINOTRANSFERASE
(Bacillus
anthracis) 		4 / 8 PHE A 239
GLY A 233
ARG A 234
LEU A 377
 None
 0.88A 1gsfB-3ruyA:
undetectable		 1gsfB-3ruyA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_C_EAAC223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 3ruy ORNITHINE
AMINOTRANSFERASE
(Bacillus
anthracis) 		4 / 8 PHE A 239
GLY A 233
ARG A 234
LEU A 377
 None
 0.88A 1gsfC-3ruyA:
undetectable		 1gsfC-3ruyA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_D_EAAD223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 3ruy ORNITHINE
AMINOTRANSFERASE
(Bacillus
anthracis) 		4 / 8 PHE A 239
GLY A 233
ARG A 234
LEU A 377
 None
 0.87A 1gsfD-3ruyA:
undetectable		 1gsfD-3ruyA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_1
(TRANSTHYRETIN)		 3ruy ORNITHINE
AMINOTRANSFERASE
(Bacillus
anthracis) 		4 / 6 LEU A 303
ALA A 256
LEU A 300
SER A 296
 None
LLP  A 255 ( 3.6A)
None
None
 1.07A 1ictB-3ruyA:
undetectable		 1ictB-3ruyA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_B_SAMB4001_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 3ruy ORNITHINE
AMINOTRANSFERASE
(Bacillus
anthracis) 		6 / 12 GLY A 338
GLY A 336
LEU A 319
LEU A 339
PRO A 375
ILE A 379
 None
 1.23A 1zq9B-3ruyA:
undetectable		 1zq9B-3ruyA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3ruy ORNITHINE
AMINOTRANSFERASE
(Bacillus
anthracis) 		3 / 3 GLY A 236
GLY A 316
GLY A 338
 None
 0.39A 3bogD-3ruyA:
undetectable		 3bogD-3ruyA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3ruy ORNITHINE
AMINOTRANSFERASE
(Bacillus
anthracis) 		5 / 11 ALA A 374
ASN A 202
ILE A 203
GLY A 197
THR A 366
 None
 1.19A 3rukD-3ruyA:
undetectable		 3rukD-3ruyA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 3ruy ORNITHINE
AMINOTRANSFERASE
(Bacillus
anthracis) 		5 / 12 HIS A 367
GLY A 197
ALA A 240
PRO A 204
LEU A 209
 None
 1.09A 3tm4B-3ruyA:
2.1		 3tm4B-3ruyA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3ruy ORNITHINE
AMINOTRANSFERASE
(Bacillus
anthracis) 		5 / 8 GLU A 133
ILE A 183
GLU A 219
ILE A 191
LEU A 222
 None
 1.32A 4mj8A-3ruyA:
undetectable		 4mj8A-3ruyA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTP_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 3ruy ORNITHINE
AMINOTRANSFERASE
(Bacillus
anthracis) 		5 / 12 GLY A 106
ALA A 107
ILE A 264
ASN A 104
SER A 296
 LLP  A 255 ( 3.5A)
LLP  A 255 ( 3.4A)
None
None
None
 1.23A 4rtpA-3ruyA:
undetectable		 4rtpA-3ruyA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 3ruy ORNITHINE
AMINOTRANSFERASE
(Bacillus
anthracis) 		5 / 12 GLY A 259
ALA A  51
ILE A  61
VAL A 261
ILE A  62
 LLP  A 255 ( 4.9A)
LLP  A 255 ( 3.9A)
None
None
None
 1.08A 4uw0A-3ruyA:
undetectable		 4uw0A-3ruyA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UY8_7_TRP71002_0
(TRYPTOPHANASE)		 3ruy ORNITHINE
AMINOTRANSFERASE
(Bacillus
anthracis) 		4 / 4 ILE A  66
ASN A  63
ILE A  61
VAL A 295
 None
 1.26A 4uy87-3ruyA:
undetectable		 4uy87-3ruyA:
3.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_0
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 3ruy ORNITHINE
AMINOTRANSFERASE
(Bacillus
anthracis) 		5 / 12 TYR A  88
GLY A  85
LEU A 257
LEU A 253
ALA A 268
 None
 1.08A 4wcxC-3ruyA:
undetectable		 4wcxC-3ruyA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_A_QI9A602_0
(CYTOCHROME P450 2D6)		 3ruy ORNITHINE
AMINOTRANSFERASE
(Bacillus
anthracis) 		5 / 9 LEU A 176
THR A 187
VAL A 221
VAL A 215
PHE A 223
 None
 1.26A 4wnvA-3ruyA:
undetectable		 4wnvA-3ruyA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_B_QI9B602_0
(CYTOCHROME P450 2D6)		 3ruy ORNITHINE
AMINOTRANSFERASE
(Bacillus
anthracis) 		5 / 9 LEU A 176
THR A 187
VAL A 221
VAL A 215
PHE A 223
 None
 1.39A 4wnvB-3ruyA:
undetectable		 4wnvB-3ruyA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_C_QI9C602_0
(CYTOCHROME P450 2D6)		 3ruy ORNITHINE
AMINOTRANSFERASE
(Bacillus
anthracis) 		5 / 9 LEU A 176
THR A 187
VAL A 221
VAL A 215
PHE A 223
 None
 1.28A 4wnvC-3ruyA:
0.0		 4wnvC-3ruyA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3ruy ORNITHINE
AMINOTRANSFERASE
(Bacillus
anthracis) 		5 / 12 GLY A 258
GLY A 260
GLY A  55
ALA A 292
LEU A 257
 LLP  A 255 ( 4.1A)
LLP  A 255 ( 4.8A)
None
None
None
 1.00A 5c0oG-3ruyA:
undetectable		 5c0oG-3ruyA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB203_0
(HYDROXYNITRILE LYASE)		 3ruy ORNITHINE
AMINOTRANSFERASE
(Bacillus
anthracis) 		4 / 4 VAL A 224
ALA A 267
ILE A 114
THR A 112
 None
 1.10A 5e4dB-3ruyA:
undetectable		 5e4dB-3ruyA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_1
(CYTOCHROME P450 3A5)		 3ruy ORNITHINE
AMINOTRANSFERASE
(Bacillus
anthracis) 		5 / 12 LEU A  84
ALA A  92
THR A  95
ALA A 267
GLY A 254
 None
None
None
None
LLP  A 255 ( 2.4A)
 1.13A 5veuA-3ruyA:
undetectable		 5veuA-3ruyA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_B_RITB602_1
(CYTOCHROME P450 3A5)		 3ruy ORNITHINE
AMINOTRANSFERASE
(Bacillus
anthracis) 		6 / 12 LEU A  84
ALA A  92
THR A  95
ALA A 267
ILE A 252
GLY A 254
 None
None
None
None
None
LLP  A 255 ( 2.4A)
 1.35A 5veuB-3ruyA:
undetectable		 5veuB-3ruyA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 3ruy ORNITHINE
AMINOTRANSFERASE
(Bacillus
anthracis) 		5 / 12 GLY A 231
ASP A 242
ILE A 228
SER A  50
LEU A 257
 None
None
LLP  A 255 ( 3.9A)
None
None
 1.05A 6ectA-3ruyA:
undetectable		 6ectA-3ruyA:
21.71