SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rv1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		 3rv1 K. POLYSPORUS DCR1
(Vanderwaltozyma
polyspora) 		3 / 3 ASP A  62
LEU A  52
LEU A  54
 None
 0.63A 1ikeA-3rv1A:
undetectable		 1ikeA-3rv1A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 3rv1 K. POLYSPORUS DCR1
(Vanderwaltozyma
polyspora) 		5 / 11 PHE A 196
ARG A 199
GLY A 228
ALA A 229
TYR A 108
 None
 1.49A 2cojA-3rv1A:
undetectable
2cojB-3rv1A:
undetectable		 2cojA-3rv1A:
23.02
2cojB-3rv1A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUF_A_AEGA394_0
(BETA-SECRETASE 1)		 3rv1 K. POLYSPORUS DCR1
(Vanderwaltozyma
polyspora) 		4 / 5 LEU A  66
ASP A  62
ILE A  65
GLY A  55
 None
 0.62A 3bufA-3rv1A:
undetectable		 3bufA-3rv1A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3P_A_ACTA1223_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 3rv1 K. POLYSPORUS DCR1
(Vanderwaltozyma
polyspora) 		4 / 5 ASP A 241
THR A 237
LEU A 240
GLU A 244
 None
 1.47A 4a3pA-3rv1A:
undetectable		 4a3pA-3rv1A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_2
(GUANINE DEAMINASE)		 3rv1 K. POLYSPORUS DCR1
(Vanderwaltozyma
polyspora) 		4 / 5 HIS A 123
LEU A 187
LEU A 194
ASP A 189
 None
 1.15A 4aqlA-3rv1A:
undetectable		 4aqlA-3rv1A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_A_IMNA201_1
(TRANSTHYRETIN)		 3rv1 K. POLYSPORUS DCR1
(Vanderwaltozyma
polyspora) 		3 / 3 LYS A  75
LEU A  71
ALA A  74
 None
 0.70A 4ikiA-3rv1A:
undetectable		 4ikiA-3rv1A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3rv1 K. POLYSPORUS DCR1
(Vanderwaltozyma
polyspora) 		3 / 3 ASP A 103
LEU A 230
ARG A 234
 None
 0.94A 5e8qA-3rv1A:
undetectable		 5e8qA-3rv1A:
18.99