SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rv6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ6_A_CAMA502_0
(CYTOCHROME P450-CAM)		 3rv6 ISOCHORISMATE
SYNTHASE/ISOCHORISMA
TE-PYRUVATE LYASE
MBTI
(Mycobacterium
tuberculosis) 		4 / 5 TYR A 224
LEU A  47
VAL A 169
ASP A  28
 None
 1.47A 1dz6A-3rv6A:
undetectable		 1dz6A-3rv6A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT3_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3rv6 ISOCHORISMATE
SYNTHASE/ISOCHORISMA
TE-PYRUVATE LYASE
MBTI
(Mycobacterium
tuberculosis) 		4 / 7 LEU A  99
LEU A 392
MET A 350
LEU A  92
 None
 0.90A 1kt3A-3rv6A:
undetectable		 1kt3A-3rv6A:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT6_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 3rv6 ISOCHORISMATE
SYNTHASE/ISOCHORISMA
TE-PYRUVATE LYASE
MBTI
(Mycobacterium
tuberculosis) 		5 / 11 LEU A  99
LEU A 392
VAL A 134
MET A 350
LEU A  92
 None
 1.20A 1kt6A-3rv6A:
undetectable		 1kt6A-3rv6A:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRJ_A_ADNA300_1
(ALPHA-TRICHOSANTHIN)		 3rv6 ISOCHORISMATE
SYNTHASE/ISOCHORISMA
TE-PYRUVATE LYASE
MBTI
(Mycobacterium
tuberculosis) 		5 / 8 ILE A 365
GLY A 370
TYR A 119
SER A 304
GLU A 308
 RVA  A 454 (-4.0A)
None
None
None
None
 1.47A 1mrjA-3rv6A:
undetectable		 1mrjA-3rv6A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_E_RTLE1_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 3rv6 ISOCHORISMATE
SYNTHASE/ISOCHORISMA
TE-PYRUVATE LYASE
MBTI
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 398
ALA A 352
VAL A 390
MET A 350
LEU A  92
 None
 1.09A 1qabE-3rv6A:
undetectable		 1qabE-3rv6A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 3rv6 ISOCHORISMATE
SYNTHASE/ISOCHORISMA
TE-PYRUVATE LYASE
MBTI
(Mycobacterium
tuberculosis) 		5 / 12 PHE A 112
GLY A 383
HIS A 117
LEU A 402
LEU A 125
 None
 1.35A 1zgyA-3rv6A:
undetectable		 1zgyA-3rv6A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1507_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 3rv6 ISOCHORISMATE
SYNTHASE/ISOCHORISMA
TE-PYRUVATE LYASE
MBTI
(Mycobacterium
tuberculosis) 		3 / 3 GLN A 122
HIS A 117
ARG A  87
 None
None
SO4  A 453 (-4.1A)
 1.09A 1zlqA-3rv6A:
undetectable		 1zlqA-3rv6A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3rv6 ISOCHORISMATE
SYNTHASE/ISOCHORISMA
TE-PYRUVATE LYASE
MBTI
(Mycobacterium
tuberculosis) 		4 / 5 ASP A 378
GLY A 421
ALA A 373
ILE A 374
 None
VAE  A 451 ( 4.2A)
None
None
 0.91A 2aofA-3rv6A:
undetectable		 2aofA-3rv6A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_A_PXLA1003_1
(PYRIDOXINE KINASE)		 3rv6 ISOCHORISMATE
SYNTHASE/ISOCHORISMA
TE-PYRUVATE LYASE
MBTI
(Mycobacterium
tuberculosis) 		4 / 8 VAL A  64
VAL A  96
LEU A  66
ASP A  97
 None
 1.03A 2ddwA-3rv6A:
undetectable		 2ddwA-3rv6A:
21.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FN1_A_SALA506_1
(SALICYLATE
SYNTHETASE, IRP9)		 3rv6 ISOCHORISMATE
SYNTHASE/ISOCHORISMA
TE-PYRUVATE LYASE
MBTI
(Mycobacterium
tuberculosis) 		5 / 11 ILE A 207
GLU A 252
GLU A 297
LEU A 404
GLY A 421
 VAE  A 451 (-4.2A)
None
MG  A 452 (-3.8A)
VAE  A 451 (-3.8A)
VAE  A 451 ( 4.2A)
 0.81A 2fn1A-3rv6A:
48.6		 2fn1A-3rv6A:
37.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FN1_B_SALB503_1
(SALICYLATE
SYNTHETASE, IRP9)		 3rv6 ISOCHORISMATE
SYNTHASE/ISOCHORISMA
TE-PYRUVATE LYASE
MBTI
(Mycobacterium
tuberculosis) 		5 / 11 ILE A 207
GLU A 252
GLU A 297
THR A 361
GLY A 421
 VAE  A 451 (-4.2A)
None
MG  A 452 (-3.8A)
VAE  A 451 (-4.7A)
VAE  A 451 ( 4.2A)
 1.03A 2fn1B-3rv6A:
48.3		 2fn1B-3rv6A:
37.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FN1_B_SALB503_1
(SALICYLATE
SYNTHETASE, IRP9)		 3rv6 ISOCHORISMATE
SYNTHASE/ISOCHORISMA
TE-PYRUVATE LYASE
MBTI
(Mycobacterium
tuberculosis) 		5 / 11 ILE A 207
GLY A 270
THR A 271
THR A 361
LYS A 438
 VAE  A 451 (-4.2A)
VAE  A 451 ( 3.8A)
VAE  A 451 ( 4.7A)
VAE  A 451 (-4.7A)
VAE  A 451 (-2.8A)
 1.16A 2fn1B-3rv6A:
48.3		 2fn1B-3rv6A:
37.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FN1_B_SALB503_1
(SALICYLATE
SYNTHETASE, IRP9)		 3rv6 ISOCHORISMATE
SYNTHASE/ISOCHORISMA
TE-PYRUVATE LYASE
MBTI
(Mycobacterium
tuberculosis) 		5 / 11 ILE A 207
THR A 271
THR A 361
GLY A 421
LYS A 438
 VAE  A 451 (-4.2A)
VAE  A 451 ( 4.7A)
VAE  A 451 (-4.7A)
VAE  A 451 ( 4.2A)
VAE  A 451 (-2.8A)
 1.12A 2fn1B-3rv6A:
48.3		 2fn1B-3rv6A:
37.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FN1_B_SALB503_1
(SALICYLATE
SYNTHETASE, IRP9)		 3rv6 ISOCHORISMATE
SYNTHASE/ISOCHORISMA
TE-PYRUVATE LYASE
MBTI
(Mycobacterium
tuberculosis) 		5 / 11 ILE A 207
THR A 361
GLY A 421
GLU A 434
LYS A 438
 VAE  A 451 (-4.2A)
VAE  A 451 (-4.7A)
VAE  A 451 ( 4.2A)
MG  A 452 ( 4.9A)
VAE  A 451 (-2.8A)
 0.98A 2fn1B-3rv6A:
48.3		 2fn1B-3rv6A:
37.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		 3rv6 ISOCHORISMATE
SYNTHASE/ISOCHORISMA
TE-PYRUVATE LYASE
MBTI
(Mycobacterium
tuberculosis) 		5 / 12 ALA A  30
LEU A  33
ALA A  34
THR A  38
GLN A  61
 None
 0.91A 2jjpA-3rv6A:
undetectable		 2jjpA-3rv6A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_3
(PROTEASE)		 3rv6 ISOCHORISMATE
SYNTHASE/ISOCHORISMA
TE-PYRUVATE LYASE
MBTI
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 416
ASP A 183
PRO A 215
VAL A 214
VAL A 212
 None
 0.97A 2nnkB-3rv6A:
undetectable		 2nnkB-3rv6A:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 3rv6 ISOCHORISMATE
SYNTHASE/ISOCHORISMA
TE-PYRUVATE LYASE
MBTI
(Mycobacterium
tuberculosis) 		4 / 8 LEU A 121
SER A 386
VAL A 206
GLY A 364
 None
 0.86A 2qd5A-3rv6A:
undetectable		 2qd5A-3rv6A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1103_0
(FERROCHELATASE)		 3rv6 ISOCHORISMATE
SYNTHASE/ISOCHORISMA
TE-PYRUVATE LYASE
MBTI
(Mycobacterium
tuberculosis) 		4 / 8 LEU A 121
SER A 386
VAL A 206
GLY A 364
 None
 0.88A 2qd5B-3rv6A:
undetectable		 2qd5B-3rv6A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_2
(HIV-1 PROTEASE)		 3rv6 ISOCHORISMATE
SYNTHASE/ISOCHORISMA
TE-PYRUVATE LYASE
MBTI
(Mycobacterium
tuberculosis) 		5 / 9 ARG A 376
ASP A 378
GLY A 421
ILE A 422
ILE A 374
 None
None
VAE  A 451 ( 4.2A)
None
None
 1.17A 3d1yB-3rv6A:
undetectable		 3d1yB-3rv6A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_1
(CYTOCHROME P450 2R1)		 3rv6 ISOCHORISMATE
SYNTHASE/ISOCHORISMA
TE-PYRUVATE LYASE
MBTI
(Mycobacterium
tuberculosis) 		4 / 5 ALA A 246
LEU A  46
GLY A 108
THR A 255
 None
 0.95A 3dl9A-3rv6A:
undetectable		 3dl9A-3rv6A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		 3rv6 ISOCHORISMATE
SYNTHASE/ISOCHORISMA
TE-PYRUVATE LYASE
MBTI
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 100
GLY A 396
VAL A 257
MET A 350
LEU A  92
 None
 1.40A 3h52A-3rv6A:
undetectable		 3h52A-3rv6A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3rv6 ISOCHORISMATE
SYNTHASE/ISOCHORISMA
TE-PYRUVATE LYASE
MBTI
(Mycobacterium
tuberculosis) 		3 / 3 ARG A  75
GLU A 102
THR A 103
 None
 0.88A 3v4tA-3rv6A:
undetectable		 3v4tA-3rv6A:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRM_A_VD3A502_1
(VITAMIN D(3)
25-HYDROXYLASE)		 3rv6 ISOCHORISMATE
SYNTHASE/ISOCHORISMA
TE-PYRUVATE LYASE
MBTI
(Mycobacterium
tuberculosis) 		5 / 12 MET A  20
LEU A 164
ILE A 161
ALA A 160
LEU A  56
 None
 0.98A 3vrmA-3rv6A:
undetectable		 3vrmA-3rv6A:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLT_A_8PRA505_1
(CYTOCHROME P450 2B4)		 3rv6 ISOCHORISMATE
SYNTHASE/ISOCHORISMA
TE-PYRUVATE LYASE
MBTI
(Mycobacterium
tuberculosis) 		5 / 8 ILE A 218
ALA A 407
VAL A 214
PRO A 215
VAL A 180
 None
 1.04A 4jltA-3rv6A:
undetectable		 4jltA-3rv6A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 3rv6 ISOCHORISMATE
SYNTHASE/ISOCHORISMA
TE-PYRUVATE LYASE
MBTI
(Mycobacterium
tuberculosis) 		4 / 8 ASP A 399
ALA A 401
TYR A  48
ASP A  51
 None
 1.00A 4k0bB-3rv6A:
undetectable		 4k0bB-3rv6A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 3rv6 ISOCHORISMATE
SYNTHASE/ISOCHORISMA
TE-PYRUVATE LYASE
MBTI
(Mycobacterium
tuberculosis) 		4 / 8 ASP A 399
ALA A 401
TYR A  48
ASP A  51
 None
 0.97A 4l7iB-3rv6A:
undetectable		 4l7iB-3rv6A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3rv6 ISOCHORISMATE
SYNTHASE/ISOCHORISMA
TE-PYRUVATE LYASE
MBTI
(Mycobacterium
tuberculosis) 		3 / 3 ASP A 395
ARG A 149
ARG A 140
 None
 0.96A 4x5iA-3rv6A:
undetectable		 4x5iA-3rv6A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_A_4LEA401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3rv6 ISOCHORISMATE
SYNTHASE/ISOCHORISMA
TE-PYRUVATE LYASE
MBTI
(Mycobacterium
tuberculosis) 		5 / 8 LEU A 392
LEU A 398
ALA A 400
LEU A 353
ALA A 132
 None
 1.16A 4z90A-3rv6A:
undetectable
4z90B-3rv6A:
undetectable
4z90C-3rv6A:
undetectable
4z90D-3rv6A:
undetectable
4z90E-3rv6A:
undetectable		 4z90A-3rv6A:
22.54
4z90B-3rv6A:
22.54
4z90C-3rv6A:
22.54
4z90D-3rv6A:
22.54
4z90E-3rv6A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF402_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3rv6 ISOCHORISMATE
SYNTHASE/ISOCHORISMA
TE-PYRUVATE LYASE
MBTI
(Mycobacterium
tuberculosis) 		5 / 7 LEU A 398
ALA A 400
LEU A 353
ALA A 132
LEU A 392
 None
 1.04A 4z90F-3rv6A:
undetectable
4z90G-3rv6A:
undetectable
4z90H-3rv6A:
undetectable
4z90J-3rv6A:
undetectable		 4z90F-3rv6A:
22.54
4z90G-3rv6A:
22.54
4z90H-3rv6A:
22.54
4z90J-3rv6A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3rv6 ISOCHORISMATE
SYNTHASE/ISOCHORISMA
TE-PYRUVATE LYASE
MBTI
(Mycobacterium
tuberculosis) 		6 / 12 ALA A 400
THR A 403
GLY A 108
LEU A 384
ALA A 106
LEU A  46
 None
 1.48A 5c0oG-3rv6A:
undetectable		 5c0oG-3rv6A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSY_B_ACRB601_2
(4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC)		 3rv6 ISOCHORISMATE
SYNTHASE/ISOCHORISMA
TE-PYRUVATE LYASE
MBTI
(Mycobacterium
tuberculosis) 		4 / 5 PHE A 112
HIS A 117
LEU A 121
PRO A 358
 None
 1.09A 5csyB-3rv6A:
undetectable		 5csyB-3rv6A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)		 3rv6 ISOCHORISMATE
SYNTHASE/ISOCHORISMA
TE-PYRUVATE LYASE
MBTI
(Mycobacterium
tuberculosis) 		3 / 3 ASP A 395
ARG A 149
ARG A 140
 None
 0.78A 5eajB-3rv6A:
undetectable		 5eajB-3rv6A:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3rv6 ISOCHORISMATE
SYNTHASE/ISOCHORISMA
TE-PYRUVATE LYASE
MBTI
(Mycobacterium
tuberculosis) 		6 / 12 GLY A 383
ALA A 362
PHE A 375
ILE A 374
PHE A 357
GLY A 115
 None
VAE  A 451 ( 4.4A)
None
None
None
None
 1.17A 5hieB-3rv6A:
undetectable		 5hieB-3rv6A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 3rv6 ISOCHORISMATE
SYNTHASE/ISOCHORISMA
TE-PYRUVATE LYASE
MBTI
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  89
LEU A 353
VAL A 110
ALA A 132
LEU A 131
 None
 0.95A 5kpcA-3rv6A:
undetectable		 5kpcA-3rv6A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 3rv6 ISOCHORISMATE
SYNTHASE/ISOCHORISMA
TE-PYRUVATE LYASE
MBTI
(Mycobacterium
tuberculosis) 		4 / 6 ARG A 188
ARG A 189
ALA A 192
PRO A 428
 None
 1.12A 5odqA-3rv6A:
undetectable		 5odqA-3rv6A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYE_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3rv6 ISOCHORISMATE
SYNTHASE/ISOCHORISMA
TE-PYRUVATE LYASE
MBTI
(Mycobacterium
tuberculosis) 		5 / 12 VAL A  60
ASP A  44
LEU A  71
ALA A  62
GLY A 108
 None
 1.27A 5syeB-3rv6A:
undetectable		 5syeB-3rv6A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 3rv6 ISOCHORISMATE
SYNTHASE/ISOCHORISMA
TE-PYRUVATE LYASE
MBTI
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 108
ALA A 401
GLY A 387
LEU A 353
ALA A 406
 None
 0.93A 5xv7A-3rv6A:
undetectable		 5xv7A-3rv6A:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GQI_A_ACTA604_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 3rv6 ISOCHORISMATE
SYNTHASE/ISOCHORISMA
TE-PYRUVATE LYASE
MBTI
(Mycobacterium
tuberculosis) 		4 / 6 PRO A 366
GLY A 370
TYR A 119
GLU A 372
 RVA  A 454 (-3.9A)
None
None
None
 1.10A 6gqiA-3rv6A:
undetectable		 6gqiA-3rv6A:
22.38