SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rva'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_1
(PROTEIN (HIV-1
PROTEASE))		 3rva ORGANOPHOSPHORUS
ACID ANHYDROLASE
(Alteromonas
macleodii) 		5 / 10 ALA A 277
ASP A 279
ILE A 422
GLY A 386
PHE A 417
 None
 1.07A 1d4sA-3rvaA:
undetectable		 1d4sA-3rvaA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 3rva ORGANOPHOSPHORUS
ACID ANHYDROLASE
(Alteromonas
macleodii) 		5 / 12 ILE A 328
LEU A 387
PHE A 332
ILE A 411
LEU A 394
 None
 1.21A 1ddrB-3rvaA:
undetectable		 1ddrB-3rvaA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRE_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3rva ORGANOPHOSPHORUS
ACID ANHYDROLASE
(Alteromonas
macleodii) 		5 / 12 ALA A 307
LEU A 387
PHE A 332
ILE A 411
LEU A 394
 None
 1.22A 1dreA-3rvaA:
undetectable		 1dreA-3rvaA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3rva ORGANOPHOSPHORUS
ACID ANHYDROLASE
(Alteromonas
macleodii) 		5 / 12 ILE A 328
LEU A 387
PHE A 332
ILE A 411
LEU A 394
 None
 1.14A 1dyiA-3rvaA:
undetectable		 1dyiA-3rvaA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKF_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 3rva ORGANOPHOSPHORUS
ACID ANHYDROLASE
(Alteromonas
macleodii) 		5 / 11 PHE A  56
VAL A  62
TYR A   8
HIS A  11
PHE A 104
 None
 1.27A 1fkfA-3rvaA:
undetectable		 1fkfA-3rvaA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKJ_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 3rva ORGANOPHOSPHORUS
ACID ANHYDROLASE
(Alteromonas
macleodii) 		5 / 11 PHE A  56
VAL A  62
TYR A   8
HIS A  11
PHE A 104
 None
 1.29A 1fkjA-3rvaA:
undetectable		 1fkjA-3rvaA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 3rva ORGANOPHOSPHORUS
ACID ANHYDROLASE
(Alteromonas
macleodii) 		5 / 12 ILE A 328
LEU A 387
PHE A 332
ILE A 411
LEU A 394
 None
 1.16A 1jolA-3rvaA:
undetectable		 1jolA-3rvaA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3rva ORGANOPHOSPHORUS
ACID ANHYDROLASE
(Alteromonas
macleodii) 		5 / 12 ILE A 328
LEU A 387
PHE A 332
ILE A 411
LEU A 394
 None
 1.15A 1rh3A-3rvaA:
undetectable		 1rh3A-3rvaA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_A_MTXA170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 3rva ORGANOPHOSPHORUS
ACID ANHYDROLASE
(Alteromonas
macleodii) 		5 / 12 ILE A 328
LEU A 387
PHE A 332
ILE A 411
LEU A 394
 None
 1.14A 1tdrA-3rvaA:
undetectable		 1tdrA-3rvaA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FKE_A_FK5A108_1
(FK506 BINDING
PROTEIN)		 3rva ORGANOPHOSPHORUS
ACID ANHYDROLASE
(Alteromonas
macleodii) 		5 / 11 PHE A  56
VAL A  62
TYR A   8
HIS A  11
PHE A 104
 None
 1.31A 2fkeA-3rvaA:
undetectable		 2fkeA-3rvaA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IT4_A_PPFA500_1
(CARBONIC ANHYDRASE 1)		 3rva ORGANOPHOSPHORUS
ACID ANHYDROLASE
(Alteromonas
macleodii) 		4 / 8 HIS A 299
HIS A 303
HIS A 366
ALA A 362
 None
 0.82A 2it4A-3rvaA:
undetectable		 2it4A-3rvaA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA2_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 3rva ORGANOPHOSPHORUS
ACID ANHYDROLASE
(Alteromonas
macleodii) 		3 / 3 LYS A  57
LYS A  51
VAL A  52
 None
 1.04A 3brfA-3rvaA:
undetectable		 3brfA-3rvaA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX94_0
(PROTEIN S100-B)		 3rva ORGANOPHOSPHORUS
ACID ANHYDROLASE
(Alteromonas
macleodii) 		3 / 3 PHE A  82
CYH A  68
PHE A  56
 None
 1.11A 3cr5X-3rvaA:
undetectable		 3cr5X-3rvaA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL0_A_FOLA160_0
(DIHYDROFOLATE
REDUCTASE)		 3rva ORGANOPHOSPHORUS
ACID ANHYDROLASE
(Alteromonas
macleodii) 		5 / 12 ILE A 328
LEU A 387
PHE A 332
ILE A 411
LEU A 394
 None
 1.19A 3ql0A-3rvaA:
undetectable		 3ql0A-3rvaA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RLB_A_VIBA191_1
(THIT)		 3rva ORGANOPHOSPHORUS
ACID ANHYDROLASE
(Alteromonas
macleodii) 		5 / 10 GLU A 384
TYR A 212
HIS A 339
GLY A 342
VAL A 380
 MN  A 453 (-2.9A)
None
MN  A 453 (-3.4A)
None
None
 1.29A 3rlbA-3rvaA:
0.0		 3rlbA-3rvaA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RLB_B_VIBB187_1
(THIT)		 3rva ORGANOPHOSPHORUS
ACID ANHYDROLASE
(Alteromonas
macleodii) 		5 / 12 GLU A 384
TYR A 212
HIS A 339
GLY A 342
VAL A 380
 MN  A 453 (-2.9A)
None
MN  A 453 (-3.4A)
None
None
 1.28A 3rlbB-3rvaA:
undetectable		 3rlbB-3rvaA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 3rva ORGANOPHOSPHORUS
ACID ANHYDROLASE
(Alteromonas
macleodii) 		4 / 7 THR A  79
LEU A 109
VAL A  32
VAL A  71
 None
 0.89A 4cp4A-3rvaA:
undetectable		 4cp4A-3rvaA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_B_ADNB401_1
(APH(2'')-ID)		 3rva ORGANOPHOSPHORUS
ACID ANHYDROLASE
(Alteromonas
macleodii) 		4 / 8 ILE A 323
ILE A 309
LEU A 387
ILE A 306
 None
 0.95A 4dtaB-3rvaA:
undetectable		 4dtaB-3rvaA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3rva ORGANOPHOSPHORUS
ACID ANHYDROLASE
(Alteromonas
macleodii) 		4 / 7 ILE A 422
THR A 259
VAL A 286
ASP A 439
 None
 1.39A 4iarA-3rvaA:
undetectable		 4iarA-3rvaA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3rva ORGANOPHOSPHORUS
ACID ANHYDROLASE
(Alteromonas
macleodii) 		3 / 3 LEU A 242
ARG A 258
MET A 436
 None
 0.81A 4m11C-3rvaA:
undetectable		 4m11C-3rvaA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDC_A_ASDA404_1
(3-KETOSTEROID
9ALPHA-HYDROXYLASE
OXYGENASE)		 3rva ORGANOPHOSPHORUS
ACID ANHYDROLASE
(Alteromonas
macleodii) 		5 / 12 MET A 436
LEU A 440
ALA A 254
LEU A 174
ASN A 248
 None
 1.49A 4qdcA-3rvaA:
undetectable		 4qdcA-3rvaA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLF_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3rva ORGANOPHOSPHORUS
ACID ANHYDROLASE
(Alteromonas
macleodii) 		5 / 11 ILE A 328
LEU A 387
PHE A 332
ILE A 411
LEU A 394
 None
 1.18A 4qlfA-3rvaA:
undetectable		 4qlfA-3rvaA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3rva ORGANOPHOSPHORUS
ACID ANHYDROLASE
(Alteromonas
macleodii) 		5 / 12 ILE A 328
LEU A 387
PHE A 332
ILE A 411
LEU A 394
 None
 1.17A 4qlgA-3rvaA:
undetectable		 4qlgA-3rvaA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3rva ORGANOPHOSPHORUS
ACID ANHYDROLASE
(Alteromonas
macleodii) 		4 / 5 ALA A 200
TYR A 199
HIS A 226
PRO A 211
 None
 1.36A 4ze2A-3rvaA:
undetectable		 4ze2A-3rvaA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 3rva ORGANOPHOSPHORUS
ACID ANHYDROLASE
(Alteromonas
macleodii) 		4 / 4 GLU A 322
PRO A 320
ILE A 323
LEU A 318
 None
 1.18A 5m45A-3rvaA:
undetectable		 5m45A-3rvaA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 3rva ORGANOPHOSPHORUS
ACID ANHYDROLASE
(Alteromonas
macleodii) 		4 / 4 GLU A 322
PRO A 320
ILE A 323
LEU A 318
 None
 1.22A 5m45D-3rvaA:
undetectable		 5m45D-3rvaA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 3rva ORGANOPHOSPHORUS
ACID ANHYDROLASE
(Alteromonas
macleodii) 		4 / 4 GLU A 322
PRO A 320
ILE A 323
LEU A 318
 None
 1.17A 5m45G-3rvaA:
undetectable		 5m45G-3rvaA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 3rva ORGANOPHOSPHORUS
ACID ANHYDROLASE
(Alteromonas
macleodii) 		4 / 4 GLU A 322
PRO A 320
ILE A 323
LEU A 318
 None
 1.23A 5m45J-3rvaA:
undetectable		 5m45J-3rvaA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3rva ORGANOPHOSPHORUS
ACID ANHYDROLASE
(Alteromonas
macleodii) 		5 / 12 ILE A 337
GLY A 338
PHE A 368
ILE A 306
ALA A 302
 None
 1.09A 5n0tA-3rvaA:
undetectable		 5n0tA-3rvaA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3rva ORGANOPHOSPHORUS
ACID ANHYDROLASE
(Alteromonas
macleodii) 		5 / 12 ILE A 337
GLY A 338
PHE A 368
ILE A 306
ALA A 302
 None
 1.08A 5n0wB-3rvaA:
undetectable		 5n0wB-3rvaA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3rva ORGANOPHOSPHORUS
ACID ANHYDROLASE
(Alteromonas
macleodii) 		5 / 12 ILE A 337
GLY A 338
PHE A 368
ILE A 306
ALA A 302
 None
 1.07A 5n0xA-3rvaA:
undetectable		 5n0xA-3rvaA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3rva ORGANOPHOSPHORUS
ACID ANHYDROLASE
(Alteromonas
macleodii) 		5 / 12 ILE A 337
GLY A 338
PHE A 368
ILE A 306
ALA A 302
 None
 1.09A 5n4iA-3rvaA:
undetectable		 5n4iA-3rvaA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_A_SAMA901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 3rva ORGANOPHOSPHORUS
ACID ANHYDROLASE
(Alteromonas
macleodii) 		5 / 12 HIS A 335
VAL A 176
ARG A 421
ILE A 256
ASP A 244
 None
None
None
None
MN  A 452 (-2.1A)
 1.24A 6bxnA-3rvaA:
undetectable		 6bxnA-3rvaA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_A_TRPA502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 3rva ORGANOPHOSPHORUS
ACID ANHYDROLASE
(Alteromonas
macleodii) 		4 / 7 TYR A 128
HIS A  34
LEU A 119
VAL A 115
 None
 1.14A 6g2pA-3rvaA:
undetectable		 6g2pA-3rvaA:
21.06