SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rvx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_CCSB381_0
(ESTROGEN RECEPTOR)		 3rvx PEPTIDASE 1
(Dermatophagoides
pteronyssinus) 		3 / 3 GLU A  44
ALA A  46
SER A 136
 CA  A 223 ( 4.9A)
None
None
 0.60A 1errB-3rvxA:
undetectable		 1errB-3rvxA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQW_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN)		 3rvx PEPTIDASE 1
(Dermatophagoides
pteronyssinus) 		5 / 12 ILE A  76
THR A  21
VAL A  22
LEU A 131
ILE A 174
 None
 1.29A 1kqwA-3rvxA:
undetectable		 1kqwA-3rvxA:
18.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 3rvx PEPTIDASE 1
(Dermatophagoides
pteronyssinus) 		7 / 10 GLN A  28
GLY A  32
SER A  33
PHE A  37
SER A  38
ALA A 171
GLY A  73
 None
 1.12A 1stfE-3rvxA:
29.8
1stfI-3rvxA:
undetectable		 1stfE-3rvxA:
32.05
1stfI-3rvxA:
19.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 3rvx PEPTIDASE 1
(Dermatophagoides
pteronyssinus) 		8 / 10 GLN A  28
GLY A  32
SER A  33
TRP A  35
PHE A  37
SER A  38
HIS A 170
ALA A 171
 None
 0.36A 1stfE-3rvxA:
29.8
1stfI-3rvxA:
undetectable		 1stfE-3rvxA:
32.05
1stfI-3rvxA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 3rvx PEPTIDASE 1
(Dermatophagoides
pteronyssinus) 		4 / 7 GLN A  28
GLY A  32
HIS A 170
TRP A 192
 None
 0.41A 3ai8A-3rvxA:
27.7		 3ai8A-3rvxA:
28.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_2
(PROTEASE)		 3rvx PEPTIDASE 1
(Dermatophagoides
pteronyssinus) 		5 / 10 ALA A 139
ILE A  80
VAL A 220
ILE A 119
ILE A  76
 None
 1.03A 3s43B-3rvxA:
undetectable		 3s43B-3rvxA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_2
(PROTEASE)		 3rvx PEPTIDASE 1
(Dermatophagoides
pteronyssinus) 		5 / 12 GLY A  39
ILE A 113
GLY A  87
GLY A  79
ILE A  80
 None
 0.93A 4q5mA-3rvxA:
undetectable		 4q5mA-3rvxA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_E_ASCE1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 3rvx PEPTIDASE 1
(Dermatophagoides
pteronyssinus) 		4 / 7 HIS A 170
ILE A 141
VAL A 140
TYR A 218
 None
 1.23A 5kkzC-3rvxA:
0.3
5kkzE-3rvxA:
undetectable		 5kkzC-3rvxA:
20.61
5kkzE-3rvxA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_K_ASCK1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 3rvx PEPTIDASE 1
(Dermatophagoides
pteronyssinus) 		4 / 7 HIS A 170
ILE A 141
VAL A 140
TYR A 218
 None
 1.23A 5kkzK-3rvxA:
undetectable
5kkzQ-3rvxA:
undetectable		 5kkzK-3rvxA:
18.12
5kkzQ-3rvxA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MLM_A_STRA401_1
(-)		 3rvx PEPTIDASE 1
(Dermatophagoides
pteronyssinus) 		5 / 12 ILE A 127
ALA A  42
SER A  38
VAL A 175
ILE A 138
 None
 1.43A 5mlmA-3rvxA:
undetectable		 5mlmA-3rvxA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_2
(TUBULIN BETA-2B
CHAIN)		 3rvx PEPTIDASE 1
(Dermatophagoides
pteronyssinus) 		3 / 3 THR A  21
PRO A  11
ARG A 128
 None
 0.83A 5nd7B-3rvxA:
undetectable		 5nd7B-3rvxA:
19.91