SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rw7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 3rw7 NUCLEAR RNA EXPORT
FACTOR 1
(Homo
sapiens) 		5 / 12 GLY A 353
ARG A 350
ILE A 295
ALA A 226
GLN A 224
 None
 1.32A 1oltA-3rw7A:
undetectable		 1oltA-3rw7A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_D_BEZD507_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3rw7 NUCLEAR RNA EXPORT
FACTOR 1
(Homo
sapiens) 		4 / 7 PHE A 152
ALA A 159
ILE A 139
ILE A 189
 None
 0.95A 1oniD-3rw7A:
undetectable
1oniF-3rw7A:
undetectable		 1oniD-3rw7A:
19.91
1oniF-3rw7A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA802_1
(TRANSPORTER)		 3rw7 NUCLEAR RNA EXPORT
FACTOR 1
(Homo
sapiens) 		4 / 6 ILE A 286
SER A 285
ARG A 258
ILE A 259
 None
 1.11A 2q72A-3rw7A:
undetectable		 2q72A-3rw7A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		 3rw7 NUCLEAR RNA EXPORT
FACTOR 1
(Homo
sapiens) 		5 / 11 SER A 305
LEU A 320
LEU A 280
LYS A 311
LEU A 315
 None
 1.02A 2xn5A-3rw7A:
undetectable		 2xn5A-3rw7A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_B_NOGB2001_1
(PROGESTERONE
RECEPTOR)		 3rw7 NUCLEAR RNA EXPORT
FACTOR 1
(Homo
sapiens) 		5 / 12 LEU A 270
ASN A 271
LEU A 227
LEU A 257
MET A 283
 None
 1.33A 3d90B-3rw7A:
undetectable		 3d90B-3rw7A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ9_A_MTXA2001_1
(DIHYDROFOLATE
REDUCTASE)		 3rw7 NUCLEAR RNA EXPORT
FACTOR 1
(Homo
sapiens) 		5 / 12 ALA A 255
LEU A 212
LEU A 247
LEU A 270
ILE A 260
 None
 0.94A 3tq9A-3rw7A:
undetectable		 3tq9A-3rw7A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQB_A_FOLA2001_0
(DIHYDROFOLATE
REDUCTASE)		 3rw7 NUCLEAR RNA EXPORT
FACTOR 1
(Homo
sapiens) 		5 / 11 ALA A 255
LEU A 212
LEU A 247
LEU A 270
ILE A 260
 None
 1.01A 3tqbA-3rw7A:
undetectable		 3tqbA-3rw7A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_2
(CDL2.3A)		 3rw7 NUCLEAR RNA EXPORT
FACTOR 1
(Homo
sapiens) 		4 / 8 ILE A 260
MET A 253
LEU A 315
ILE A 312
 None
 0.96A 5ieoA-3rw7A:
undetectable		 5ieoA-3rw7A:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_0
(CYTOCHROME P450 1A1)		 3rw7 NUCLEAR RNA EXPORT
FACTOR 1
(Homo
sapiens) 		5 / 12 ASN A 301
ASN A 325
LEU A 298
ASN A 297
GLY A 231
 None
 1.24A 6dwnA-3rw7A:
undetectable		 6dwnA-3rw7A:
15.65