SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rwa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		 3rwa FLUORESCENT PROTEIN
FP480
(Entacmaea
quadricolor) 		4 / 5 PRO A 219
LEU A 224
THR A 214
ARG A  53
 None
 1.29A 1i2wA-3rwaA:
undetectable		 1i2wA-3rwaA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3rwa FLUORESCENT PROTEIN
FP480
(Entacmaea
quadricolor) 		4 / 7 LEU A 217
ILE A 140
ILE A 146
PHE A 158
 None
 0.88A 1uwjA-3rwaA:
undetectable		 1uwjA-3rwaA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)		 3rwa FLUORESCENT PROTEIN
FP480
(Entacmaea
quadricolor) 		4 / 6 ARG A  30
GLY A 226
THR A   9
ARG A 162
 NRQ  A 133 ( 3.8A)
None
None
NRQ  A 133 ( 2.7A)
 1.00A 2f7fA-3rwaA:
undetectable		 2f7fA-3rwaA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1002_0
(ALDEHYDE
DEHYDROGENASE A)		 3rwa FLUORESCENT PROTEIN
FP480
(Entacmaea
quadricolor) 		3 / 3 GLY A 226
ARG A 227
TYR A  11
 None
 0.82A 2opxA-3rwaA:
undetectable		 2opxA-3rwaA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3rwa FLUORESCENT PROTEIN
FP480
(Entacmaea
quadricolor) 		4 / 6 GLY A 226
GLY A 222
PHE A 149
PHE A 150
 None
 0.95A 2qx6A-3rwaA:
undetectable
2qx6B-3rwaA:
undetectable		 2qx6A-3rwaA:
20.16
2qx6B-3rwaA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		 3rwa FLUORESCENT PROTEIN
FP480
(Entacmaea
quadricolor) 		5 / 12 GLN A 204
GLY A 209
VAL A 235
ASP A 126
ALA A 124
 None
 1.18A 3d91B-3rwaA:
undetectable		 3d91B-3rwaA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 3rwa FLUORESCENT PROTEIN
FP480
(Entacmaea
quadricolor) 		3 / 3 LYS A  15
SER A  70
GLN A 152
 None
 1.21A 3si7A-3rwaA:
undetectable		 3si7A-3rwaA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M93_B_ACTB303_0
(S25-26 FAB (IGG1K)
HEAVY CHAIN
S25-26 FAB (IGG1K)
LIGHT CHAIN)		 3rwa FLUORESCENT PROTEIN
FP480
(Entacmaea
quadricolor) 		4 / 5 GLY A 107
ALA A  50
PHE A 139
GLU A  48
 None
None
None
NRQ  A 133 ( 3.9A)
 1.06A 4m93B-3rwaA:
undetectable
4m93C-3rwaA:
undetectable		 4m93B-3rwaA:
19.44
4m93C-3rwaA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ACL_A_SASA1111_1
(MCG)		 3rwa FLUORESCENT PROTEIN
FP480
(Entacmaea
quadricolor) 		4 / 7 TYR A  26
TYR A 218
GLU A 225
PHE A 149
 None
 1.18A 5aclA-3rwaA:
undetectable		 5aclA-3rwaA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 3rwa FLUORESCENT PROTEIN
FP480
(Entacmaea
quadricolor) 		3 / 3 LYS A  15
PRO A  16
LYS A  18
 None
 1.00A 5y9yA-3rwaA:
undetectable		 5y9yA-3rwaA:
21.62