SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rwg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_B_T44B328_1
(TRANSTHYRETIN)		 3rwg MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS I
(Macaca
mulatta) 		4 / 8 LEU A 272
LYS A 243
ALA A 205
THR A 187
 None
 0.94A 1ie4B-3rwgA:
undetectable
1ie4D-3rwgA:
undetectable		 1ie4B-3rwgA:
17.04
1ie4D-3rwgA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 3rwg MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS I
(Macaca
mulatta) 		5 / 10 ALA A  49
THR A  31
LEU A 179
MET A   5
VAL A  28
 None
 1.42A 2wuzA-3rwgA:
undetectable		 2wuzA-3rwgA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 3rwg MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS I
(Macaca
mulatta) 		5 / 10 ALA A  49
THR A  31
LEU A 179
MET A   5
VAL A  28
 None
 1.39A 2wuzB-3rwgA:
undetectable		 2wuzB-3rwgA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YK1_H_NCTH300_1
(FAB FRAGMENT, HEAVY
CHAIN
FAB FRAGMENT, LIGHT
CHAIN)		 3rwg MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS I
(Macaca
mulatta) 		5 / 10 ILE A 124
SER A 116
TYR A  84
TYR A  85
ALA A  81
 None
 1.10A 2yk1H-3rwgA:
9.3
2yk1L-3rwgA:
11.4		 2yk1H-3rwgA:
22.86
2yk1L-3rwgA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA511_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3rwg MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS I
(Macaca
mulatta) 		4 / 8 TYR A 123
TYR A  84
TYR A 118
HIS A  93
 None
 1.04A 2zm8A-3rwgA:
undetectable		 2zm8A-3rwgA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		 3rwg MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS I
(Macaca
mulatta) 		3 / 3 ARG A 170
GLU A 163
TYR A   7
 XPE  A 277 (-3.1A)
XPE  A 277 ( 4.7A)
None
 0.90A 3k37B-3rwgA:
undetectable		 3k37B-3rwgA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O14_A_NIOA300_1
(ANTI-ECFSIGMA
FACTOR, CHRR)		 3rwg MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS I
(Macaca
mulatta) 		4 / 7 ARG A 202
ALA A 246
VAL A 194
VAL A 248
 None
 0.65A 3o14A-3rwgA:
undetectable		 3o14A-3rwgA:
23.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UPR_A_1KXA277_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 3rwg MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS I
(Macaca
mulatta) 		7 / 10 TYR A   9
ILE A  95
TYR A  99
SER A 116
TYR A 123
ILE A 124
TRP A 147
 None
 0.35A 3uprA-3rwgA:
34.0		 3uprA-3rwgA:
85.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UPR_C_1KXC277_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 3rwg MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS I
(Macaca
mulatta) 		7 / 10 TYR A   9
ILE A  95
TYR A  99
SER A 116
TYR A 123
ILE A 124
TRP A 147
 None
 0.32A 3uprC-3rwgA:
34.2		 3uprC-3rwgA:
85.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VRI_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 3rwg MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS I
(Macaca
mulatta) 		6 / 10 TYR A   9
TYR A  99
SER A 116
TYR A 123
ILE A 124
TRP A 147
 None
 0.34A 3vriA-3rwgA:
33.9
3vriC-3rwgA:
undetectable		 3vriA-3rwgA:
85.51
3vriC-3rwgA:
3.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VRJ_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 3rwg MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS I
(Macaca
mulatta) 		7 / 12 TYR A   9
ILE A  95
TYR A  99
SER A 116
TYR A 123
ILE A 124
TRP A 147
 None
 0.40A 3vrjA-3rwgA:
34.0
3vrjC-3rwgA:
undetectable		 3vrjA-3rwgA:
85.51
3vrjC-3rwgA:
5.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_D_MTXD301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 3rwg MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS I
(Macaca
mulatta) 		5 / 11 GLY A 128
ALA A 153
LEU A 130
HIS A 114
GLN A 115
 None
 1.15A 4l8fD-3rwgA:
undetectable		 4l8fD-3rwgA:
20.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5J6H_A_NCAA402_0
(H-2 CLASS I
HISTOCOMPATIBILITY
ANTIGEN, Q10 ALPHA
CHAIN)		 3rwg MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS I
(Macaca
mulatta) 		3 / 3 PRO A  47
ARG A  48
GLU A  53
 None
 0.43A 5j6hA-3rwgA:
33.7		 5j6hA-3rwgA:
76.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5U98_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 3rwg MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS I
(Macaca
mulatta) 		7 / 10 TYR A   9
ILE A  95
TYR A  99
SER A 116
TYR A 123
ILE A 124
TRP A 147
 None
 0.34A 5u98A-3rwgA:
34.1		 5u98A-3rwgA:
85.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5U98_D_1KXD301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 3rwg MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS I
(Macaca
mulatta) 		7 / 10 TYR A   9
ILE A  95
TYR A  99
SER A 116
TYR A 123
ILE A 124
TRP A 147
 None
 0.36A 5u98D-3rwgA:
33.8		 5u98D-3rwgA:
85.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D6T_D_FYPD406_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
HUMAN GABA-A
RECEPTOR SUBUNIT
GAMMA-2)		 3rwg MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS I
(Macaca
mulatta) 		5 / 11 HIS A  74
ASP A 137
TYR A 118
ALA A 140
THR A 143
 None
 1.43A 6d6tD-3rwgA:
2.3
6d6tE-3rwgA:
2.4		 6d6tD-3rwgA:
19.21
6d6tE-3rwgA:
20.50