SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rwk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3rwk INULINASE
(Aspergillus
ficuum) 		4 / 8 SER X 482
HIS X  33
SER X 469
PHE X 473
 None
 1.15A 1eqbA-3rwkX:
undetectable
1eqbB-3rwkX:
undetectable		 1eqbA-3rwkX:
22.69
1eqbB-3rwkX:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3rwk INULINASE
(Aspergillus
ficuum) 		4 / 8 PHE X 473
SER X 482
HIS X  33
SER X 469
 None
 1.13A 1eqbA-3rwkX:
undetectable
1eqbB-3rwkX:
undetectable		 1eqbA-3rwkX:
22.69
1eqbB-3rwkX:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3rwk INULINASE
(Aspergillus
ficuum) 		4 / 8 SER X 482
HIS X  33
SER X 469
PHE X 473
 None
 1.16A 1eqbC-3rwkX:
undetectable
1eqbD-3rwkX:
undetectable		 1eqbC-3rwkX:
22.69
1eqbD-3rwkX:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3rwk INULINASE
(Aspergillus
ficuum) 		4 / 8 PHE X 473
SER X 482
HIS X  33
SER X 469
 None
 1.13A 1eqbC-3rwkX:
undetectable
1eqbD-3rwkX:
undetectable		 1eqbC-3rwkX:
22.69
1eqbD-3rwkX:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC439_0
(ADP-RIBOSYL CYCLASE)		 3rwk INULINASE
(Aspergillus
ficuum) 		3 / 3 TRP X  72
PHE X  57
TRP X 149
 None
 1.40A 1r15C-3rwkX:
undetectable		 1r15C-3rwkX:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF469_0
(ADP-RIBOSYL CYCLASE)		 3rwk INULINASE
(Aspergillus
ficuum) 		3 / 3 TRP X  72
PHE X  57
TRP X 149
 None
 1.39A 1r15F-3rwkX:
undetectable		 1r15F-3rwkX:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_G_NCAG479_0
(ADP-RIBOSYL CYCLASE)		 3rwk INULINASE
(Aspergillus
ficuum) 		3 / 3 TRP X  72
PHE X  57
TRP X 149
 None
 1.40A 1r15G-3rwkX:
undetectable		 1r15G-3rwkX:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_H_NCAH489_0
(ADP-RIBOSYL CYCLASE)		 3rwk INULINASE
(Aspergillus
ficuum) 		3 / 3 TRP X  72
PHE X  57
TRP X 149
 None
 1.39A 1r15H-3rwkX:
undetectable		 1r15H-3rwkX:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_A_ACTA544_0
(ACETYLCHOLINESTERASE)		 3rwk INULINASE
(Aspergillus
ficuum) 		5 / 8 GLY X  46
ALA X 123
ALA X 103
TRP X 149
PHE X  57
 None
 1.47A 2ha4A-3rwkX:
undetectable		 2ha4A-3rwkX:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACTB601_0
(ACETYLCHOLINESTERASE)		 3rwk INULINASE
(Aspergillus
ficuum) 		5 / 7 GLY X  46
ALA X 123
ALA X 103
TRP X 149
PHE X  57
 None
 1.46A 2ha4B-3rwkX:
undetectable		 2ha4B-3rwkX:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1121_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3rwk INULINASE
(Aspergillus
ficuum) 		4 / 5 VAL X 513
SER X 366
VAL X 510
SER X 364
 None
 1.36A 2j9cA-3rwkX:
undetectable
2j9cB-3rwkX:
undetectable
2j9cC-3rwkX:
undetectable		 2j9cA-3rwkX:
10.81
2j9cB-3rwkX:
10.81
2j9cC-3rwkX:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 3rwk INULINASE
(Aspergillus
ficuum) 		4 / 5 LEU X 122
ALA X 140
TRP X  72
MET X 190
 None
 1.09A 2oaxA-3rwkX:
undetectable		 2oaxA-3rwkX:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 3rwk INULINASE
(Aspergillus
ficuum) 		5 / 12 ILE X  50
ALA X  75
GLY X 146
ARG X  29
PHE X  34
 None
 1.16A 2okcB-3rwkX:
undetectable		 2okcB-3rwkX:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBO_A_CAMA442_0
(CYTOCHROME P450-CAM)		 3rwk INULINASE
(Aspergillus
ficuum) 		5 / 10 VAL X 417
VAL X 470
ASP X 483
ILE X 481
VAL X 472
 None
 1.39A 2qboA-3rwkX:
undetectable		 2qboA-3rwkX:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_L_CSCL1383_2
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 3rwk INULINASE
(Aspergillus
ficuum) 		4 / 4 THR X 255
LEU X 268
MET X 254
MET X 319
 None
 1.47A 2vavL-3rwkX:
0.0		 2vavL-3rwkX:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_2
(PROTEASE)		 3rwk INULINASE
(Aspergillus
ficuum) 		5 / 9 ASP X 296
ASP X 440
ILE X 437
GLY X 445
VAL X 470
 None
MAN  X 517 (-2.4A)
None
None
None
 1.30A 3ekyB-3rwkX:
undetectable		 3ekyB-3rwkX:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3rwk INULINASE
(Aspergillus
ficuum) 		3 / 3 ASN X 293
HIS X 447
VAL X 446
 ACT  X1428 (-3.7A)
None
None
 0.71A 3elzB-3rwkX:
undetectable		 3elzB-3rwkX:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_2
(PROTEIN S100-A4)		 3rwk INULINASE
(Aspergillus
ficuum) 		4 / 6 LEU X 225
SER X 221
ILE X 270
PHE X 274
 None
 0.97A 3ko0B-3rwkX:
undetectable		 3ko0B-3rwkX:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_1
(PROTEIN S100-A4)		 3rwk INULINASE
(Aspergillus
ficuum) 		4 / 6 LEU X 225
SER X 221
ILE X 270
PHE X 274
 None
 0.92A 3ko0S-3rwkX:
undetectable		 3ko0S-3rwkX:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 3rwk INULINASE
(Aspergillus
ficuum) 		5 / 11 THR X 134
GLN X 133
ALA X 164
GLY X 170
THR X 169
 None
 1.14A 3mg0H-3rwkX:
undetectable
3mg0I-3rwkX:
undetectable		 3mg0H-3rwkX:
18.84
3mg0I-3rwkX:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 3rwk INULINASE
(Aspergillus
ficuum) 		5 / 11 ARG X 431
SER X 428
ILE X 418
VAL X 472
VAL X 470
 None
 1.29A 3rf4A-3rwkX:
undetectable
3rf4C-3rwkX:
undetectable		 3rf4A-3rwkX:
13.80
3rf4C-3rwkX:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 3rwk INULINASE
(Aspergillus
ficuum) 		5 / 11 ARG X 431
SER X 428
ILE X 418
VAL X 472
VAL X 470
 None
 1.34A 3rf4A-3rwkX:
undetectable
3rf4B-3rwkX:
undetectable		 3rf4A-3rwkX:
13.80
3rf4B-3rwkX:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 3rwk INULINASE
(Aspergillus
ficuum) 		5 / 11 ARG X 431
SER X 428
ILE X 418
VAL X 472
VAL X 470
 None
 1.32A 3rf4B-3rwkX:
undetectable
3rf4C-3rwkX:
undetectable		 3rf4B-3rwkX:
13.80
3rf4C-3rwkX:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_D_LOCD502_1
(TUBULIN BETA CHAIN)		 3rwk INULINASE
(Aspergillus
ficuum) 		5 / 12 ALA X  89
ASN X  45
ALA X 103
ALA X 140
ILE X  48
 None
 1.13A 3ut5D-3rwkX:
undetectable		 3ut5D-3rwkX:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOR_A_FLPA711_1
(LACTOTRANSFERRIN)		 3rwk INULINASE
(Aspergillus
ficuum) 		4 / 7 GLY X 114
VAL X 143
PRO X 119
ASN X 109
 None
 0.65A 4forA-3rwkX:
undetectable		 4forA-3rwkX:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 3rwk INULINASE
(Aspergillus
ficuum) 		4 / 6 ASN X  65
ALA X  64
TYR X  39
ASP X  92
 None
 1.21A 4mdbA-3rwkX:
undetectable		 4mdbA-3rwkX:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_A_BQ1A1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 3rwk INULINASE
(Aspergillus
ficuum) 		3 / 3 GLU X  97
ALA X  98
PHE X  99
 None
None
FRU  X 801 (-4.0A)
 0.55A 4v1fA-3rwkX:
undetectable		 4v1fA-3rwkX:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_C_BQ1C1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 3rwk INULINASE
(Aspergillus
ficuum) 		3 / 3 GLU X  97
ALA X  98
PHE X  99
 None
None
FRU  X 801 (-4.0A)
 0.56A 4v1fC-3rwkX:
undetectable		 4v1fC-3rwkX:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X30_A_T44A401_1
(THYROXINE-BINDING
GLOBULIN)		 3rwk INULINASE
(Aspergillus
ficuum) 		5 / 9 ALA X 503
GLN X 368
LEU X 382
LEU X 505
LEU X 496
 None
 1.44A 4x30A-3rwkX:
undetectable		 4x30A-3rwkX:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 3rwk INULINASE
(Aspergillus
ficuum) 		5 / 12 GLY X 266
GLY X 264
PRO X 261
ALA X 262
ARG X 295
 NA  X 521 ( 4.2A)
MAN  X 519 (-3.3A)
None
None
MAN  X 517 (-3.1A)
 1.27A 5bw4B-3rwkX:
undetectable		 5bw4B-3rwkX:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_A_ACTA708_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)		 3rwk INULINASE
(Aspergillus
ficuum) 		3 / 3 GLY X 171
GLY X 170
GLN X 197
 None
 0.50A 5imsA-3rwkX:
undetectable		 5imsA-3rwkX:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 3rwk INULINASE
(Aspergillus
ficuum) 		3 / 3 ASP X 282
ASN X 223
PHE X 274
 None
 0.81A 5jglB-3rwkX:
undetectable		 5jglB-3rwkX:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYE_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3rwk INULINASE
(Aspergillus
ficuum) 		5 / 12 GLU X 233
VAL X 234
ASP X 176
ALA X 300
GLY X  46
 FRU  X 801 (-2.8A)
None
FRU  X 801 (-3.0A)
None
None
 1.29A 5syeB-3rwkX:
undetectable		 5syeB-3rwkX:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6N_A_SALA505_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 3rwk INULINASE
(Aspergillus
ficuum) 		4 / 8 SER X 201
HIS X 194
MET X 190
THR X 126
 None
 1.28A 5u6nA-3rwkX:
undetectable		 5u6nA-3rwkX:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6N_B_SALB504_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 3rwk INULINASE
(Aspergillus
ficuum) 		4 / 6 SER X 201
HIS X 194
MET X 190
THR X 126
 None
 1.21A 5u6nB-3rwkX:
undetectable		 5u6nB-3rwkX:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3rwk INULINASE
(Aspergillus
ficuum) 		3 / 3 GLY X 435
THR X 330
PRO X 327
 None
 0.61A 5v5zA-3rwkX:
undetectable		 5v5zA-3rwkX:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W3J_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3rwk INULINASE
(Aspergillus
ficuum) 		4 / 8 VAL X 353
GLU X 478
GLN X 349
GLY X 347
 None
 0.88A 5w3jB-3rwkX:
undetectable		 5w3jB-3rwkX:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 3rwk INULINASE
(Aspergillus
ficuum) 		5 / 12 VAL X 403
SER X 402
THR X 499
PHE X 396
VAL X 459
 None
 1.33A 6a93B-3rwkX:
undetectable		 6a93B-3rwkX:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 3rwk INULINASE
(Aspergillus
ficuum) 		4 / 7 SER X 321
HIS X 447
GLY X 294
ARG X 431
 MAN  X 519 (-4.9A)
None
None
None
 0.90A 6btxA-3rwkX:
undetectable		 6btxA-3rwkX:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 3rwk INULINASE
(Aspergillus
ficuum) 		4 / 5 GLY X 311
ASP X 310
ARG X 313
ARG X 312
 None
None
SO4  X 995 (-2.7A)
None
 1.29A 6dwdB-3rwkX:
undetectable
6dwdD-3rwkX:
undetectable		 6dwdB-3rwkX:
21.52
6dwdD-3rwkX:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 3rwk INULINASE
(Aspergillus
ficuum) 		4 / 5 ARG X 313
ARG X 312
GLY X 311
ASP X 310
 SO4  X 995 (-2.7A)
None
None
None
 1.23A 6dwjB-3rwkX:
undetectable
6dwjD-3rwkX:
undetectable		 6dwjB-3rwkX:
21.52
6dwjD-3rwkX:
21.52