SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rwl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA502_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 3rwl CYTOCHROME P450
ALKANE HYDROXYLASE 1
CYP153A7
(Sphingopyxis
macrogoltabida) 		3 / 3 LEU A 269
HIS A 272
LYS A 273
 None
 1.12A 1y7iA-3rwlA:
undetectable		 1y7iA-3rwlA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 3rwl CYTOCHROME P450
ALKANE HYDROXYLASE 1
CYP153A7
(Sphingopyxis
macrogoltabida) 		4 / 8 SER A  20
ASN A 402
ILE A  84
ASP A  85
 None
 1.01A 2v57A-3rwlA:
undetectable		 2v57A-3rwlA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 3rwl CYTOCHROME P450
ALKANE HYDROXYLASE 1
CYP153A7
(Sphingopyxis
macrogoltabida) 		4 / 8 SER A  20
ASN A 402
ILE A  84
ASP A  85
 None
 1.02A 2v57C-3rwlA:
undetectable		 2v57C-3rwlA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 3rwl CYTOCHROME P450
ALKANE HYDROXYLASE 1
CYP153A7
(Sphingopyxis
macrogoltabida) 		5 / 12 SER A 182
ILE A 253
LEU A 227
LEU A 251
GLY A 247
 None
None
None
HEM  A 417 ( 4.3A)
None
 1.15A 3k2hA-3rwlA:
undetectable		 3k2hA-3rwlA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 3rwl CYTOCHROME P450
ALKANE HYDROXYLASE 1
CYP153A7
(Sphingopyxis
macrogoltabida) 		5 / 12 GLY A 247
ASN A 248
ALA A 103
ALA A  77
LEU A  96
 None
 1.25A 3mteA-3rwlA:
undetectable		 3mteA-3rwlA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		 3rwl CYTOCHROME P450
ALKANE HYDROXYLASE 1
CYP153A7
(Sphingopyxis
macrogoltabida) 		3 / 3 ARG A 335
GLU A 294
ARG A 405
 None
 0.97A 4mwvA-3rwlA:
undetectable		 4mwvA-3rwlA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3rwl CYTOCHROME P450
ALKANE HYDROXYLASE 1
CYP153A7
(Sphingopyxis
macrogoltabida) 		5 / 12 GLY A  80
GLY A  81
ASP A  76
ILE A  84
GLY A  52
 None
 1.06A 4obwB-3rwlA:
undetectable		 4obwB-3rwlA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3rwl CYTOCHROME P450
ALKANE HYDROXYLASE 1
CYP153A7
(Sphingopyxis
macrogoltabida) 		4 / 8 THR A 160
THR A 179
GLY A 256
GLY A 255
 None
None
HEM  A 417 (-3.3A)
HEM  A 417 (-4.0A)
 0.74A 4qvvK-3rwlA:
undetectable
4qvvL-3rwlA:
undetectable		 4qvvK-3rwlA:
19.16
4qvvL-3rwlA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3rwl CYTOCHROME P450
ALKANE HYDROXYLASE 1
CYP153A7
(Sphingopyxis
macrogoltabida) 		4 / 8 THR A 160
THR A 179
GLY A 256
GLY A 255
 None
None
HEM  A 417 (-3.3A)
HEM  A 417 (-4.0A)
 0.75A 4qvvY-3rwlA:
undetectable
4qvvZ-3rwlA:
undetectable		 4qvvY-3rwlA:
19.16
4qvvZ-3rwlA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 3rwl CYTOCHROME P450
ALKANE HYDROXYLASE 1
CYP153A7
(Sphingopyxis
macrogoltabida) 		3 / 3 ASP A  18
SER A  56
TYR A  54
 None
 0.62A 5glmA-3rwlA:
undetectable		 5glmA-3rwlA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 3rwl CYTOCHROME P450
ALKANE HYDROXYLASE 1
CYP153A7
(Sphingopyxis
macrogoltabida) 		5 / 12 LEU A  96
ILE A  88
GLY A  87
ASP A  86
LEU A  98
 None
 1.16A 5h5fA-3rwlA:
undetectable		 5h5fA-3rwlA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB308_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3rwl CYTOCHROME P450
ALKANE HYDROXYLASE 1
CYP153A7
(Sphingopyxis
macrogoltabida) 		3 / 3 LEU A 178
ILE A 253
TYR A 245
 None
 0.60A 5uunB-3rwlA:
undetectable		 5uunB-3rwlA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3rwl CYTOCHROME P450
ALKANE HYDROXYLASE 1
CYP153A7
(Sphingopyxis
macrogoltabida) 		5 / 7 ASN A 402
HIS A 304
ASP A  85
ASP A  86
GLY A  80
 None
 1.33A 5x7pA-3rwlA:
undetectable		 5x7pA-3rwlA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AGG_Z_AG2Z503_0
(TRNA(ILE2)
2-AGMATINYLCYTIDINE
SYNTHETASE TIAS)		 3rwl CYTOCHROME P450
ALKANE HYDROXYLASE 1
CYP153A7
(Sphingopyxis
macrogoltabida) 		4 / 5 ASN A 369
VAL A 367
CYH A 366
ARG A 365
 None
HEM  A 417 (-4.8A)
HEM  A 417 (-2.2A)
None
 1.19A 6aggZ-3rwlA:
undetectable		 6aggZ-3rwlA:
12.19