SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rwo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A65_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3rwo GTP-BINDING PROTEIN
YPT32/YPT11
(Saccharomyces
cerevisiae) 		5 / 12 ALA B  70
TYR B  82
VAL B  17
TRP B 107
GLY B  71
 MG  B1176 ( 4.4A)
None
None
None
None
 1.23A 3a65A-3rwoB:
undetectable		 3a65A-3rwoB:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 3rwo GTP-BINDING PROTEIN
YPT32/YPT11
(Saccharomyces
cerevisiae) 		3 / 3 GLY B  85
TRP B  67
VAL B  17
 None
 0.65A 3n62B-3rwoB:
undetectable		 3n62B-3rwoB:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N65_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 3rwo GTP-BINDING PROTEIN
YPT32/YPT11
(Saccharomyces
cerevisiae) 		3 / 3 GLY B  85
TRP B  67
VAL B  17
 None
 0.66A 3n65B-3rwoB:
undetectable		 3n65B-3rwoB:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 3rwo GTP-BINDING PROTEIN
YPT32/YPT11
(Saccharomyces
cerevisiae) 		3 / 3 GLY B  85
TRP B  67
VAL B  17
 None
 0.65A 3n66B-3rwoB:
undetectable		 3n66B-3rwoB:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPR_A_PAUA404_0
(PANTOTHENATE KINASE
3)		 3rwo GTP-BINDING PROTEIN
YPT32/YPT11
(Saccharomyces
cerevisiae) 		4 / 5 GLU B  73
GLY B  20
SER B  22
GLY B  23
 None
None
None
GDP  B4032 (-3.4A)
 0.96A 5kprA-3rwoB:
undetectable		 5kprA-3rwoB:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3rwo GTP-BINDING PROTEIN
YPT32/YPT11
(Saccharomyces
cerevisiae) 		3 / 3 GLY B  85
TRP B  67
VAL B  17
 None
 0.66A 5vuoB-3rwoB:
undetectable		 5vuoB-3rwoB:
20.15