SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rwr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XYT_D_TC9D1206_2 (SOLUBLE ACETYLCHOLINE RECEPTOR)	3rwr	DNA REPAIR PROTEIN XRCC4 (Homo sapiens)	4 / 8	THR A 37 GLN A 21 ARG A 3 ILE A 5	None	0.85A	2xytE-3rwrA: undetectable	2xytE-3rwrA: 20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XYT_G_TC9G1206_2 (SOLUBLE ACETYLCHOLINE RECEPTOR)	3rwr	DNA REPAIR PROTEIN XRCC4 (Homo sapiens)	4 / 8	THR A 37 GLN A 21 ARG A 3 ILE A 5	None	0.80A	2xytH-3rwrA: undetectable	2xytH-3rwrA: 20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3H5G_A_LEIA16_0 (COIL SER L16D-PEN)	3rwr	DNA REPAIR PROTEIN XRCC4 (Homo sapiens)	4 / 6	LEU A 70 GLU A 69 LYS A 99 LEU A 108	None	0.91A	3h5gA-3rwrA: undetectable 3h5gC-3rwrA: undetectable	3h5gA-3rwrA: 12.88 3h5gC-3rwrA: 12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ESH_A_1YNA602_1 (LANOSTEROL 14-ALPHA DEMETHYLASE)	3rwr	DNA REPAIR PROTEIN XRCC4 (Homo sapiens)	5 / 12	ALA A 56 ILE A 5 PHE A 86 LEU A 113 PHE A 32	None	1.00A	5eshA-3rwrA: undetectable	5eshA-3rwrA: 15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6A7P_A_9SCA601_0 (SERUM ALBUMIN)	3rwr	DNA REPAIR PROTEIN XRCC4 (Homo sapiens)	5 / 12	LEU A 28 PHE A 111 VAL A 122 GLY A 109 LEU A 74	None	1.25A	6a7pA-3rwrA: undetectable	6a7pA-3rwrA: 12.73

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2XYT_D_TC9D1206_2","SOLUBLE ACETYLCHOLINE RECEPTOR;SOLUBLE ACETYLCHOLINE RECEPTOR","3rwr","DNA REPAIR PROTEIN XRCC4","Homo sapiens",4,"THR A  37;GLN A  21;ARG A   3;ILE A   5","None","0.85A","2xytE-3rwrA:undetectable","2xytE-3rwrA:20.27"],["2XYT_G_TC9G1206_2","SOLUBLE ACETYLCHOLINE RECEPTOR;SOLUBLE ACETYLCHOLINE RECEPTOR","3rwr","DNA REPAIR PROTEIN XRCC4","Homo sapiens",4,"THR A  37;GLN A  21;ARG A   3;ILE A   5","None","0.80A","2xytH-3rwrA:undetectable","2xytH-3rwrA:20.27"],["3H5G_A_LEIA16_0","COIL SER L16D-PEN","3rwr","DNA REPAIR PROTEIN XRCC4","Homo sapiens",4,"LEU A  70;GLU A  69;LYS A  99;LEU A 108","None","0.91A","3h5gA-3rwrA:undetectable;3h5gC-3rwrA:undetectable","3h5gA-3rwrA:12.88;3h5gC-3rwrA:12.88"],["5ESH_A_1YNA602_1","LANOSTEROL 14-ALPHA DEMETHYLASE","3rwr","DNA REPAIR PROTEIN XRCC4","Homo sapiens",5,"ALA A  56;ILE A   5;PHE A  86;LEU A 113;PHE A  32","None","1.00A","5eshA-3rwrA:undetectable","5eshA-3rwrA:15.03"],["6A7P_A_9SCA601_0","SERUM ALBUMIN","3rwr","DNA REPAIR PROTEIN XRCC4","Homo sapiens",5,"LEU A  28;PHE A 111;VAL A 122;GLY A 109;LEU A  74","None","1.25A","6a7pA-3rwrA:undetectable","6a7pA-3rwrA:12.73"]]