SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rwx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 3rwx HYPOTHETICAL
BACTERIAL OUTER
MEMBRANE PROTEIN
(Bacteroides
fragilis) 		4 / 4 ILE A 121
LEU A 117
VAL A  74
ILE A  72
 MLY  A 126 ( 4.1A)
MLY  A 130 ( 4.3A)
None
None
 0.90A 1fm6D-3rwxA:
undetectable		 1fm6D-3rwxA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)		 3rwx HYPOTHETICAL
BACTERIAL OUTER
MEMBRANE PROTEIN
(Bacteroides
fragilis) 		5 / 12 LEU A 213
GLY A 214
PHE A 216
LYS A 268
ALA A 210
 None
None
None
MLY  A 267 ( 3.2A)
None
 1.22A 1hvyB-3rwxA:
undetectable		 1hvyB-3rwxA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)		 3rwx HYPOTHETICAL
BACTERIAL OUTER
MEMBRANE PROTEIN
(Bacteroides
fragilis) 		5 / 12 THR A 265
ILE A 275
VAL A 169
PHE A 216
LEU A 165
 None
 1.14A 1wsvA-3rwxA:
undetectable		 1wsvA-3rwxA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_B_THHB4001_0
(AMINOMETHYLTRANSFERA
SE)		 3rwx HYPOTHETICAL
BACTERIAL OUTER
MEMBRANE PROTEIN
(Bacteroides
fragilis) 		5 / 12 THR A 265
ILE A 275
VAL A 169
PHE A 216
LEU A 165
 None
 1.18A 1wsvB-3rwxA:
undetectable		 1wsvB-3rwxA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA505_0
(RNA POLYMERASE
3D-POL)		 3rwx HYPOTHETICAL
BACTERIAL OUTER
MEMBRANE PROTEIN
(Bacteroides
fragilis) 		3 / 3 CYH A 180
ASN A 160
LYS A 162
 MLY  A 181 ( 3.9A)
MLY  A 161 ( 3.9A)
MLY  A 161 (-2.8A)
 1.44A 4k50A-3rwxA:
undetectable		 4k50A-3rwxA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3rwx HYPOTHETICAL
BACTERIAL OUTER
MEMBRANE PROTEIN
(Bacteroides
fragilis) 		3 / 3 ASP A 176
LYS A 198
LEU A 196
 None
MLY  A 197 ( 3.6A)
MLY  A 197 ( 3.6A)
 1.01A 4ptjA-3rwxA:
undetectable		 4ptjA-3rwxA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3rwx HYPOTHETICAL
BACTERIAL OUTER
MEMBRANE PROTEIN
(Bacteroides
fragilis) 		4 / 5 PHE A 266
LEU A 165
GLY A 198
ILE A 247
 MLY  A 267 ( 4.6A)
None
MLY  A 197 ( 2.4A)
MLY  A 267 ( 4.4A)
 0.99A 5ik1A-3rwxA:
undetectable		 5ik1A-3rwxA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Q1S_A_AWYA1103_0
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 3rwx HYPOTHETICAL
BACTERIAL OUTER
MEMBRANE PROTEIN
(Bacteroides
fragilis) 		4 / 6 VAL A 155
ILE A 233
LYS A 182
TYR A 159
 None
MLY  A 232 ( 3.9A)
MLY  A 181 ( 3.3A)
MLY  A 283 ( 3.9A)
 1.40A 5q1sA-3rwxA:
undetectable		 5q1sA-3rwxA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 3rwx HYPOTHETICAL
BACTERIAL OUTER
MEMBRANE PROTEIN
(Bacteroides
fragilis) 		5 / 12 PHE A  95
ILE A  72
ASP A  69
GLY A  70
ASN A  31
 None
None
None
GOL  A 291 ( 4.5A)
MLY  A  32 (-3.9A)
 1.23A 6r2eA-3rwxA:
undetectable		 6r2eA-3rwxA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_B_FFOB403_0
(THYMIDYLATE SYNTHASE)		 3rwx HYPOTHETICAL
BACTERIAL OUTER
MEMBRANE PROTEIN
(Bacteroides
fragilis) 		5 / 10 PHE A  95
ILE A  72
ASP A  69
GLY A  70
ASN A  31
 None
None
None
GOL  A 291 ( 4.5A)
MLY  A  32 (-3.9A)
 1.22A 6r2eB-3rwxA:
undetectable		 6r2eB-3rwxA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_C_FFOC404_0
(THYMIDYLATE SYNTHASE)		 3rwx HYPOTHETICAL
BACTERIAL OUTER
MEMBRANE PROTEIN
(Bacteroides
fragilis) 		5 / 10 PHE A  95
ILE A  72
ASP A  69
GLY A  70
ASN A  31
 None
None
None
GOL  A 291 ( 4.5A)
MLY  A  32 (-3.9A)
 1.20A 6r2eC-3rwxA:
undetectable		 6r2eC-3rwxA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_D_FFOD403_0
(THYMIDYLATE SYNTHASE)		 3rwx HYPOTHETICAL
BACTERIAL OUTER
MEMBRANE PROTEIN
(Bacteroides
fragilis) 		5 / 10 PHE A  95
ILE A  72
ASP A  69
GLY A  70
ASN A  31
 None
None
None
GOL  A 291 ( 4.5A)
MLY  A  32 (-3.9A)
 1.20A 6r2eD-3rwxA:
undetectable		 6r2eD-3rwxA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 3rwx HYPOTHETICAL
BACTERIAL OUTER
MEMBRANE PROTEIN
(Bacteroides
fragilis) 		5 / 11 PHE A  95
ILE A  72
ASP A  69
GLY A  70
ASN A  31
 None
None
None
GOL  A 291 ( 4.5A)
MLY  A  32 (-3.9A)
 1.22A 6r2eF-3rwxA:
undetectable		 6r2eF-3rwxA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 3rwx HYPOTHETICAL
BACTERIAL OUTER
MEMBRANE PROTEIN
(Bacteroides
fragilis) 		5 / 11 PHE A  95
ILE A  72
ASP A  69
GLY A  70
ASN A  31
 None
None
None
GOL  A 291 ( 4.5A)
MLY  A  32 (-3.9A)
 1.23A 6r2eG-3rwxA:
undetectable		 6r2eG-3rwxA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 3rwx HYPOTHETICAL
BACTERIAL OUTER
MEMBRANE PROTEIN
(Bacteroides
fragilis) 		5 / 12 PHE A  95
ILE A  72
ASP A  69
GLY A  70
ASN A  31
 None
None
None
GOL  A 291 ( 4.5A)
MLY  A  32 (-3.9A)
 1.22A 6r2eH-3rwxA:
undetectable		 6r2eH-3rwxA:
21.64