SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rxy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3rxy NIF3 PROTEIN
(Sphaerobacter
thermophilus) 		5 / 12 GLY A  41
SER A 273
HIS A 247
ILE A 248
HIS A 133
 None
 1.21A 1kyvA-3rxyA:
undetectable
1kyvE-3rxyA:
undetectable		 1kyvA-3rxyA:
23.94
1kyvE-3rxyA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_C_RBFC503_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3rxy NIF3 PROTEIN
(Sphaerobacter
thermophilus) 		5 / 12 HIS A 133
GLY A  41
SER A 273
HIS A 247
ILE A 248
 None
 1.24A 1kyvB-3rxyA:
undetectable
1kyvC-3rxyA:
undetectable		 1kyvB-3rxyA:
23.94
1kyvC-3rxyA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3rxy NIF3 PROTEIN
(Sphaerobacter
thermophilus) 		5 / 12 HIS A 133
GLY A  41
SER A 273
HIS A 247
ILE A 248
 None
 1.25A 1kyvC-3rxyA:
undetectable
1kyvD-3rxyA:
undetectable		 1kyvC-3rxyA:
23.94
1kyvD-3rxyA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3rxy NIF3 PROTEIN
(Sphaerobacter
thermophilus) 		5 / 12 HIS A 133
GLY A  41
SER A 273
HIS A 247
ILE A 248
 None
 1.28A 1kyvD-3rxyA:
undetectable
1kyvE-3rxyA:
undetectable		 1kyvD-3rxyA:
23.94
1kyvE-3rxyA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_B_STIB4_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3rxy NIF3 PROTEIN
(Sphaerobacter
thermophilus) 		4 / 6 LEU A 102
VAL A 183
ILE A 226
ARG A 219
 FMT  A 279 ( 4.5A)
None
None
None
 1.11A 1opjB-3rxyA:
undetectable		 1opjB-3rxyA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_2
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3rxy NIF3 PROTEIN
(Sphaerobacter
thermophilus) 		3 / 3 LEU A 252
HIS A 247
ILE A 224
 None
 0.70A 1s9pB-3rxyA:
undetectable		 1s9pB-3rxyA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))		 3rxy NIF3 PROTEIN
(Sphaerobacter
thermophilus) 		5 / 12 GLY A  67
GLY A  68
ALA A  27
ASN A 114
PRO A  46
 None
 1.01A 2dpmA-3rxyA:
undetectable		 2dpmA-3rxyA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_F_GCSF710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 3rxy NIF3 PROTEIN
(Sphaerobacter
thermophilus) 		4 / 8 HIS A  63
ASP A 251
ILE A 224
HIS A 133
 None
 1.10A 2xadB-3rxyA:
2.1		 2xadB-3rxyA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_G_GCSG710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 3rxy NIF3 PROTEIN
(Sphaerobacter
thermophilus) 		4 / 8 HIS A  63
ASP A 251
ILE A 224
HIS A 133
 None
 1.11A 2xadC-3rxyA:
2.1		 2xadC-3rxyA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_A_CHDA4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3rxy NIF3 PROTEIN
(Sphaerobacter
thermophilus) 		5 / 9 LEU A 262
PRO A 135
SER A  26
VAL A 139
GLY A 254
 None
 1.47A 3hcoA-3rxyA:
0.6		 3hcoA-3rxyA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3rxy NIF3 PROTEIN
(Sphaerobacter
thermophilus) 		5 / 10 LEU A 262
PRO A 135
SER A  26
VAL A 139
GLY A 254
 None
 1.44A 3hcoB-3rxyA:
undetectable		 3hcoB-3rxyA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_1
(PROTEASE)		 3rxy NIF3 PROTEIN
(Sphaerobacter
thermophilus) 		5 / 9 ALA A 167
ASP A 163
ILE A 165
VAL A 197
ILE A 148
 None
 1.12A 3nuoA-3rxyA:
undetectable		 3nuoA-3rxyA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1
(CYTOCHROME P450 2A6)		 3rxy NIF3 PROTEIN
(Sphaerobacter
thermophilus) 		4 / 5 PHE A 129
ILE A  44
GLY A  45
THR A 118
 None
 1.00A 4ejjC-3rxyA:
undetectable		 4ejjC-3rxyA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3rxy NIF3 PROTEIN
(Sphaerobacter
thermophilus) 		4 / 6 GLU A 230
ILE A 226
ASN A 204
VAL A 218
 None
None
CL  A 277 (-4.2A)
None
 1.04A 4ejwB-3rxyA:
undetectable		 4ejwB-3rxyA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_F_CAMF502_0
(CAMPHOR
5-MONOOXYGENASE)		 3rxy NIF3 PROTEIN
(Sphaerobacter
thermophilus) 		4 / 4 TYR A 258
THR A   6
VAL A  38
ILE A 132
 None
 1.36A 4jx1F-3rxyA:
undetectable		 4jx1F-3rxyA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 3rxy NIF3 PROTEIN
(Sphaerobacter
thermophilus) 		5 / 12 TYR A 258
GLU A 173
ARG A 271
VAL A 269
LEU A   9
 None
 1.44A 4k38B-3rxyA:
undetectable		 4k38B-3rxyA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3rxy NIF3 PROTEIN
(Sphaerobacter
thermophilus) 		4 / 7 HIS A 247
ASP A 251
SER A  26
ASP A  43
 None
 1.33A 4ndnC-3rxyA:
undetectable		 4ndnC-3rxyA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN)		 3rxy NIF3 PROTEIN
(Sphaerobacter
thermophilus) 		5 / 12 ARG A 105
GLY A 101
ALA A 210
GLY A 206
GLU A 229
 FMT  A 279 ( 3.8A)
None
None
None
None
 1.27A 4r29C-3rxyA:
undetectable		 4r29C-3rxyA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_A_QI9A602_0
(CYTOCHROME P450 2D6)		 3rxy NIF3 PROTEIN
(Sphaerobacter
thermophilus) 		5 / 9 LEU A 102
GLU A 230
VAL A 221
VAL A 209
LEU A 242
 FMT  A 279 ( 4.5A)
None
None
None
None
 1.45A 4wnvA-3rxyA:
undetectable		 4wnvA-3rxyA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3rxy NIF3 PROTEIN
(Sphaerobacter
thermophilus) 		4 / 7 ALA A 167
ARG A 141
GLY A 140
GLU A 138
 None
 0.80A 5bs8A-3rxyA:
undetectable
5bs8C-3rxyA:
undetectable
5bs8D-3rxyA:
undetectable		 5bs8A-3rxyA:
20.68
5bs8C-3rxyA:
20.68
5bs8D-3rxyA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 3rxy NIF3 PROTEIN
(Sphaerobacter
thermophilus) 		4 / 7 ALA A 167
ARG A 141
GLY A 140
GLU A 138
 None
 0.82A 5bs8A-3rxyA:
undetectable
5bs8B-3rxyA:
undetectable
5bs8C-3rxyA:
undetectable		 5bs8A-3rxyA:
20.68
5bs8B-3rxyA:
23.73
5bs8C-3rxyA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_E_GFNE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 3rxy NIF3 PROTEIN
(Sphaerobacter
thermophilus) 		4 / 7 ALA A 167
ARG A 141
GLY A 140
GLU A 138
 None
 0.78A 5btdA-3rxyA:
undetectable
5btdB-3rxyA:
undetectable
5btdC-3rxyA:
undetectable		 5btdA-3rxyA:
20.68
5btdB-3rxyA:
23.73
5btdC-3rxyA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3rxy NIF3 PROTEIN
(Sphaerobacter
thermophilus) 		4 / 7 ALA A 167
ARG A 141
GLY A 140
GLU A 138
 None
 0.79A 5btdA-3rxyA:
0.8
5btdC-3rxyA:
undetectable
5btdD-3rxyA:
undetectable		 5btdA-3rxyA:
20.68
5btdC-3rxyA:
20.68
5btdD-3rxyA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 3rxy NIF3 PROTEIN
(Sphaerobacter
thermophilus) 		4 / 6 ALA A 167
ARG A 141
GLY A 140
GLU A 138
 None
 0.83A 5btgA-3rxyA:
undetectable
5btgB-3rxyA:
undetectable
5btgC-3rxyA:
undetectable		 5btgA-3rxyA:
20.68
5btgB-3rxyA:
23.73
5btgC-3rxyA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3rxy NIF3 PROTEIN
(Sphaerobacter
thermophilus) 		4 / 7 ALA A 167
ARG A 141
GLY A 140
GLU A 138
 None
 0.74A 5btgA-3rxyA:
undetectable
5btgC-3rxyA:
undetectable
5btgD-3rxyA:
undetectable		 5btgA-3rxyA:
20.68
5btgC-3rxyA:
20.68
5btgD-3rxyA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D75_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 3rxy NIF3 PROTEIN
(Sphaerobacter
thermophilus) 		5 / 11 ASP A 163
VAL A 183
ILE A 243
ALA A 167
ILE A 148
 None
 1.15A 5d75A-3rxyA:
undetectable		 5d75A-3rxyA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZNI_A_YMZA302_0
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3rxy NIF3 PROTEIN
(Sphaerobacter
thermophilus) 		5 / 9 VAL A 198
GLY A  89
VAL A  86
GLU A  87
PRO A  91
 None
 1.38A 5zniA-3rxyA:
undetectable		 5zniA-3rxyA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_A_W9TA201_0
(GALECTIN-1)		 3rxy NIF3 PROTEIN
(Sphaerobacter
thermophilus) 		4 / 8 HIS A  88
ARG A 141
GLU A  87
ARG A  80
 None
 0.98A 6b94A-3rxyA:
undetectable		 6b94A-3rxyA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CCV_C_RFPC1205_1
(-)		 3rxy NIF3 PROTEIN
(Sphaerobacter
thermophilus) 		5 / 12 ASP A 251
LEU A 130
PRO A 135
ILE A 132
HIS A 247
 None
 1.45A 6ccvC-3rxyA:
undetectable		 6ccvC-3rxyA:
14.66