SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rxz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)		 3rxz POLYSACCHARIDE
DEACETYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 5 HIS A 137
GLU A 131
ALA A 134
HIS A  85
 None
 1.34A 1errA-3rxzA:
undetectable
1errB-3rxzA:
undetectable		 1errA-3rxzA:
24.01
1errB-3rxzA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_C_EAAC223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 3rxz POLYSACCHARIDE
DEACETYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 GLY A  75
LEU A  68
VAL A  61
PHE A  78
 None
 1.01A 1gsfC-3rxzA:
undetectable		 1gsfC-3rxzA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 3rxz POLYSACCHARIDE
DEACETYLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 TYR A 141
VAL A 178
LEU A 156
HIS A 151
GLU A 119
 None
 1.15A 1mmkA-3rxzA:
undetectable		 1mmkA-3rxzA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3rxz POLYSACCHARIDE
DEACETYLASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ASP A  31
HIS A 104
HIS A 108
 ZN  A 299 (-2.1A)
ZN  A 299 (-3.4A)
ZN  A 299 (-3.4A)
 0.52A 1oe1A-3rxzA:
undetectable		 1oe1A-3rxzA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3rxz POLYSACCHARIDE
DEACETYLASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ASP A  31
HIS A 104
HIS A 108
 ZN  A 299 (-2.1A)
ZN  A 299 (-3.4A)
ZN  A 299 (-3.4A)
 0.52A 1oe3A-3rxzA:
undetectable		 1oe3A-3rxzA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3rxz POLYSACCHARIDE
DEACETYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 HIS A 104
PRO A  80
SER A 110
ASP A  31
 ZN  A 299 (-3.4A)
None
None
ZN  A 299 (-2.1A)
 1.14A 1p7lC-3rxzA:
undetectable		 1p7lC-3rxzA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3rxz POLYSACCHARIDE
DEACETYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 HIS A 104
PRO A  80
SER A 110
ASP A  31
 ZN  A 299 (-3.4A)
None
None
ZN  A 299 (-2.1A)
 1.13A 1p7lD-3rxzA:
undetectable		 1p7lD-3rxzA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3rxz POLYSACCHARIDE
DEACETYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 HIS A 104
PRO A  80
SER A 110
ASP A  31
 ZN  A 299 (-3.4A)
None
None
ZN  A 299 (-2.1A)
 1.12A 1rg9A-3rxzA:
undetectable		 1rg9A-3rxzA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3rxz POLYSACCHARIDE
DEACETYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 HIS A 104
PRO A  80
SER A 110
ASP A  31
 ZN  A 299 (-3.4A)
None
None
ZN  A 299 (-2.1A)
 1.13A 1rg9B-3rxzA:
undetectable		 1rg9B-3rxzA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3rxz POLYSACCHARIDE
DEACETYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 HIS A 104
PRO A  80
SER A 110
ASP A  31
 ZN  A 299 (-3.4A)
None
None
ZN  A 299 (-2.1A)
 1.13A 1rg9C-3rxzA:
undetectable		 1rg9C-3rxzA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3rxz POLYSACCHARIDE
DEACETYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 HIS A 104
PRO A  80
SER A 110
ASP A  31
 ZN  A 299 (-3.4A)
None
None
ZN  A 299 (-2.1A)
 1.12A 1rg9D-3rxzA:
undetectable		 1rg9D-3rxzA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3rxz POLYSACCHARIDE
DEACETYLASE
(Mycolicibacteriu
m
smegmatis) 		6 / 12 LEU A  65
LEU A  68
GLY A  98
ARG A  96
ALA A  95
ALA A 134
 None
 1.46A 2br4C-3rxzA:
undetectable		 2br4C-3rxzA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_B_CHDB304_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 3rxz POLYSACCHARIDE
DEACETYLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 10 GLN A  53
GLU A  33
THR A  83
ARG A 245
GLY A  60
 None
 1.44A 2dysA-3rxzA:
1.2
2dysB-3rxzA:
0.0
2dysT-3rxzA:
0.0		 2dysA-3rxzA:
20.83
2dysB-3rxzA:
22.07
2dysT-3rxzA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_O_CHDO229_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 3rxz POLYSACCHARIDE
DEACETYLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 ARG A 245
GLY A  60
GLN A  53
GLU A  33
THR A  83
 None
 1.30A 2eijG-3rxzA:
undetectable
2eijN-3rxzA:
undetectable
2eijO-3rxzA:
undetectable		 2eijG-3rxzA:
15.81
2eijN-3rxzA:
20.83
2eijO-3rxzA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OBV_A_SAMA501_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1)		 3rxz POLYSACCHARIDE
DEACETYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 HIS A 104
PRO A  80
SER A 110
ASP A  31
 ZN  A 299 (-3.4A)
None
None
ZN  A 299 (-2.1A)
 1.13A 2obvA-3rxzA:
undetectable		 2obvA-3rxzA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P02_A_SAMA2_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-2)		 3rxz POLYSACCHARIDE
DEACETYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 HIS A 104
PRO A  80
SER A 110
ASP A  31
 ZN  A 299 (-3.4A)
None
None
ZN  A 299 (-2.1A)
 1.18A 2p02A-3rxzA:
undetectable		 2p02A-3rxzA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_B_CLUB809_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 3rxz POLYSACCHARIDE
DEACETYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 ASP A 164
MET A 148
TYR A 141
HIS A 104
 None
None
None
ZN  A 299 (-3.4A)
 1.46A 2pncB-3rxzA:
undetectable		 2pncB-3rxzA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3rxz POLYSACCHARIDE
DEACETYLASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ASP A  31
HIS A 104
HIS A 108
 ZN  A 299 (-2.1A)
ZN  A 299 (-3.4A)
ZN  A 299 (-3.4A)
 0.52A 2xxgA-3rxzA:
undetectable		 2xxgA-3rxzA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_C_CUC1339_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3rxz POLYSACCHARIDE
DEACETYLASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 ASP A  31
HIS A 104
HIS A 108
 ZN  A 299 (-2.1A)
ZN  A 299 (-3.4A)
ZN  A 299 (-3.4A)
 0.56A 2xxgC-3rxzA:
undetectable		 2xxgC-3rxzA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_B_CHDB1086_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 3rxz POLYSACCHARIDE
DEACETYLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 GLN A  53
GLU A  33
THR A  83
ARG A 245
GLY A  60
 None
 1.47A 3abmA-3rxzA:
undetectable
3abmB-3rxzA:
undetectable
3abmT-3rxzA:
undetectable		 3abmA-3rxzA:
20.83
3abmB-3rxzA:
22.07
3abmT-3rxzA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_O_CHDO229_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 3rxz POLYSACCHARIDE
DEACETYLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 ARG A 245
GLY A  60
GLN A  53
GLU A  33
THR A  83
 None
 1.26A 3ag1G-3rxzA:
undetectable
3ag1N-3rxzA:
undetectable
3ag1O-3rxzA:
undetectable		 3ag1G-3rxzA:
15.81
3ag1N-3rxzA:
20.83
3ag1O-3rxzA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 3rxz POLYSACCHARIDE
DEACETYLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A 183
GLU A 185
GLU A 147
ASN A 149
LEU A 111
 None
 1.32A 3eigA-3rxzA:
undetectable		 3eigA-3rxzA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3rxz POLYSACCHARIDE
DEACETYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 LEU A 111
PRO A  80
SER A  34
GLY A 126
 None
 1.09A 3hcnA-3rxzA:
undetectable		 3hcnA-3rxzA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_4
(PROTEASE)		 3rxz POLYSACCHARIDE
DEACETYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 4 ASP A  29
ASP A  31
GLY A 105
THR A  38
 ZN  A 299 ( 4.4A)
ZN  A 299 (-2.1A)
None
None
 1.30A 3tl9B-3rxzA:
undetectable		 3tl9B-3rxzA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3rxz POLYSACCHARIDE
DEACETYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 HIS A 104
PRO A  80
SER A 110
ASP A  31
 ZN  A 299 (-3.4A)
None
None
ZN  A 299 (-2.1A)
 1.13A 4kttA-3rxzA:
undetectable		 4kttA-3rxzA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3rxz POLYSACCHARIDE
DEACETYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 HIS A 104
PRO A  80
SER A 110
ASP A  31
 ZN  A 299 (-3.4A)
None
None
ZN  A 299 (-2.1A)
 1.11A 4kttC-3rxzA:
undetectable		 4kttC-3rxzA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3rxz POLYSACCHARIDE
DEACETYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 HIS A 104
PRO A  80
SER A 110
ASP A  31
 ZN  A 299 (-3.4A)
None
None
ZN  A 299 (-2.1A)
 1.14A 4ndnA-3rxzA:
undetectable		 4ndnA-3rxzA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_B_SAMB1548_0
(CYSTATHIONINE
BETA-SYNTHASE)		 3rxz POLYSACCHARIDE
DEACETYLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 LEU A 167
PRO A 187
VAL A 188
THR A 237
ASP A 193
 None
 1.30A 4uuuB-3rxzA:
undetectable		 4uuuB-3rxzA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT7_A_TOPA302_1
(RV2671)		 3rxz POLYSACCHARIDE
DEACETYLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 ILE A 273
THR A  76
GLY A 269
GLU A 100
GLU A 275
 None
 1.42A 4xt7A-3rxzA:
undetectable		 4xt7A-3rxzA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT8_A_TMQA302_1
(RV2671)		 3rxz POLYSACCHARIDE
DEACETYLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ILE A 273
GLY A 269
ALA A 268
GLU A 100
GLU A 275
 None
 1.31A 4xt8A-3rxzA:
undetectable		 4xt8A-3rxzA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_0
(PROLINE--TRNA LIGASE)		 3rxz POLYSACCHARIDE
DEACETYLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 VAL A 178
PRO A 153
THR A 152
GLU A 119
GLY A 113
 None
 1.41A 4ydqB-3rxzA:
undetectable		 4ydqB-3rxzA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_ADNA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3rxz POLYSACCHARIDE
DEACETYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 HIS A 104
PRO A  80
SER A 110
ASP A  31
 ZN  A 299 (-3.4A)
None
None
ZN  A 299 (-2.1A)
 1.12A 5a1iA-3rxzA:
undetectable		 5a1iA-3rxzA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 3rxz POLYSACCHARIDE
DEACETYLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 11 VAL A 265
VAL A  24
VAL A 267
PHE A 255
LEU A 224
 None
 0.80A 5e4dB-3rxzA:
undetectable		 5e4dB-3rxzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_A_ACTA301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3rxz POLYSACCHARIDE
DEACETYLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 6 ASP A  29
ASP A  31
HIS A 104
HIS A 108
HIS A 239
 ZN  A 299 ( 4.4A)
ZN  A 299 (-2.1A)
ZN  A 299 (-3.4A)
ZN  A 299 (-3.4A)
None
 0.54A 5ncdA-3rxzA:
16.7
5ncdD-3rxzA:
16.8		 5ncdA-3rxzA:
22.48
5ncdD-3rxzA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_C_ACTC301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3rxz POLYSACCHARIDE
DEACETYLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 6 ASP A  29
ASP A  31
HIS A 104
HIS A 108
HIS A 239
 ZN  A 299 ( 4.4A)
ZN  A 299 (-2.1A)
ZN  A 299 (-3.4A)
ZN  A 299 (-3.4A)
None
 0.56A 5ncdB-3rxzA:
16.7
5ncdC-3rxzA:
16.7		 5ncdB-3rxzA:
22.48
5ncdC-3rxzA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_D_ACTD301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3rxz POLYSACCHARIDE
DEACETYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 4 ASP A  29
HIS A 104
HIS A 108
HIS A 239
 ZN  A 299 ( 4.4A)
ZN  A 299 (-3.4A)
ZN  A 299 (-3.4A)
None
 0.26A 5ncdD-3rxzA:
16.8		 5ncdD-3rxzA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_B_AZMB302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3rxz POLYSACCHARIDE
DEACETYLASE
(Mycolicibacteriu
m
smegmatis) 		6 / 8 ASP A  29
ASP A  31
HIS A 104
HIS A 108
PRO A 144
HIS A 239
 ZN  A 299 ( 4.4A)
ZN  A 299 (-2.1A)
ZN  A 299 (-3.4A)
ZN  A 299 (-3.4A)
None
None
 0.63A 5nekB-3rxzA:
16.8		 5nekB-3rxzA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_D_AZMD302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3rxz POLYSACCHARIDE
DEACETYLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 8 ASP A  29
ASP A  31
HIS A 104
HIS A 108
HIS A 239
 ZN  A 299 ( 4.4A)
ZN  A 299 (-2.1A)
ZN  A 299 (-3.4A)
ZN  A 299 (-3.4A)
None
 0.55A 5nekD-3rxzA:
16.8		 5nekD-3rxzA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_A_ACTA302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3rxz POLYSACCHARIDE
DEACETYLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 6 ASP A  29
ASP A  31
HIS A 104
HIS A 108
HIS A 239
 ZN  A 299 ( 4.4A)
ZN  A 299 (-2.1A)
ZN  A 299 (-3.4A)
ZN  A 299 (-3.4A)
None
 0.53A 5nelA-3rxzA:
16.6
5nelD-3rxzA:
16.6		 5nelA-3rxzA:
22.48
5nelD-3rxzA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_C_ACTC302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3rxz POLYSACCHARIDE
DEACETYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 ASP A  29
HIS A 104
HIS A 108
HIS A 239
 ZN  A 299 ( 4.4A)
ZN  A 299 (-3.4A)
ZN  A 299 (-3.4A)
None
 0.24A 5nelB-3rxzA:
16.7
5nelC-3rxzA:
16.7		 5nelB-3rxzA:
22.48
5nelC-3rxzA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 3rxz POLYSACCHARIDE
DEACETYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 HIS A 104
PRO A  80
SER A 110
ASP A  31
 ZN  A 299 (-3.4A)
None
None
ZN  A 299 (-2.1A)
 1.10A 5t8sB-3rxzA:
undetectable		 5t8sB-3rxzA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 3rxz POLYSACCHARIDE
DEACETYLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 PHE A 159
ILE A 127
GLY A 140
THR A 152
VAL A  79
 None
 1.07A 5x66F-3rxzA:
undetectable		 5x66F-3rxzA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3rxz POLYSACCHARIDE
DEACETYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 6 LEU A 162
VAL A 184
LEU A 186
VAL A 277
 None
 0.98A 5x7zA-3rxzA:
undetectable		 5x7zA-3rxzA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA605_0
(ALPHA-AMYLASE)		 3rxz POLYSACCHARIDE
DEACETYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 GLY A  81
ASP A  31
ASP A  29
PRO A 240
 None
ZN  A 299 (-2.1A)
ZN  A 299 ( 4.4A)
CL  A 298 (-3.7A)
 0.91A 6ag0A-3rxzA:
6.7		 6ag0A-3rxzA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3rxz POLYSACCHARIDE
DEACETYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 HIS A 104
PRO A  80
SER A 110
ASP A  31
 ZN  A 299 (-3.4A)
None
None
ZN  A 299 (-2.1A)
 1.17A 6fbnB-3rxzA:
undetectable		 6fbnB-3rxzA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBO_A_ADNA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3rxz POLYSACCHARIDE
DEACETYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 HIS A 104
PRO A  80
SER A 110
ASP A  31
 ZN  A 299 (-3.4A)
None
None
ZN  A 299 (-2.1A)
 1.11A 6fboA-3rxzA:
undetectable		 6fboA-3rxzA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCB_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3rxz POLYSACCHARIDE
DEACETYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 HIS A 104
PRO A  80
SER A 110
ASP A  31
 ZN  A 299 (-3.4A)
None
None
ZN  A 299 (-2.1A)
 1.07A 6fcbA-3rxzA:
undetectable		 6fcbA-3rxzA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCD_A_ADNA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3rxz POLYSACCHARIDE
DEACETYLASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 HIS A 104
PRO A  80
SER A 110
ASP A  31
 ZN  A 299 (-3.4A)
None
None
ZN  A 299 (-2.1A)
 1.10A 6fcdA-3rxzA:
undetectable		 6fcdA-3rxzA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_G_CHDG104_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 3rxz POLYSACCHARIDE
DEACETYLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 10 ARG A 245
GLY A  60
GLN A  53
GLU A  33
THR A  83
 None
 1.22A 6nmfG-3rxzA:
undetectable
6nmfN-3rxzA:
0.0
6nmfO-3rxzA:
undetectable		 6nmfG-3rxzA:
15.81
6nmfN-3rxzA:
20.83
6nmfO-3rxzA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_O_CHDO302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 3rxz POLYSACCHARIDE
DEACETYLASE
(Mycolicibacteriu
m
smegmatis) 		5 / 10 ARG A 245
GLY A  60
GLN A  53
GLU A  33
THR A  83
 None
 1.21A 6nmpG-3rxzA:
0.0
6nmpN-3rxzA:
0.1
6nmpO-3rxzA:
0.0		 6nmpG-3rxzA:
15.81
6nmpN-3rxzA:
20.83
6nmpO-3rxzA:
22.07