SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ry9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A28_A_STRA1_1
(PROGESTERONE
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		11 / 12 LEU A  32
ASN A  33
LEU A  35
GLN A  39
MET A  70
ARG A  80
LEU A 111
MET A 115
CYH A 205
THR A 208
PHE A 219
 1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.4A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.5A)
None
1CA  A 249 (-3.6A)
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 0.64A 1a28A-3ry9A:
36.7		 1a28A-3ry9A:
62.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A28_B_STRB2_1
(PROGESTERONE
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		10 / 12 LEU A  29
LEU A  32
ASN A  33
LEU A  35
GLN A  39
MET A  70
ARG A  80
MET A 115
CYH A 205
THR A 208
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.4A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
 0.53A 1a28B-3ry9A:
36.6		 1a28B-3ry9A:
62.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A28_B_STRB2_1
(PROGESTERONE
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		10 / 12 LEU A  32
ASN A  33
LEU A  35
GLN A  39
MET A  70
ARG A  80
LEU A 111
MET A 115
CYH A 205
THR A 208
 1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.4A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.5A)
None
1CA  A 249 (-3.6A)
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
 0.73A 1a28B-3ry9A:
36.6		 1a28B-3ry9A:
62.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1A28_B_STRB2_1
(PROGESTERONE
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		5 / 12 LEU A  35
LEU A  32
LEU A  29
LEU A  77
MET A 115
 1CA  A 249 ( 4.4A)
1CA  A 249 (-3.9A)
1CA  A 249 ( 3.8A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.6A)
 1.35A 1a28B-3ry9A:
36.6		 1a28B-3ry9A:
62.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GS4_A_ZK5A1918_1
(ANDROGEN RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		9 / 12 LEU A  32
ASN A  33
LEU A  35
GLY A  36
GLN A  39
TRP A  69
MET A  70
MET A 108
PHE A 219
 1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.4A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
None
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.6A)
1CA  A 249 (-4.3A)
 0.69A 1gs4A-3ry9A:
36.7		 1gs4A-3ry9A:
55.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M2Z_A_DEXA301_1
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		10 / 12 ASN A  33
GLY A  36
GLN A  39
TRP A  69
MET A  70
ARG A  80
CYH A 205
THR A 208
PHE A 219
LEU A 223
 1CA  A 249 (-3.0A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
None
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.5A)
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
None
 0.44A 1m2zA-3ry9A:
35.8		 1m2zA-3ry9A:
71.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M2Z_A_DEXA301_1
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		10 / 12 ASN A  33
GLY A  36
GLN A  39
TRP A  69
MET A  70
ARG A  80
MET A 115
CYH A 205
THR A 208
LEU A 223
 1CA  A 249 (-3.0A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
None
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
None
 0.67A 1m2zA-3ry9A:
35.8		 1m2zA-3ry9A:
71.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M2Z_A_DEXA301_1
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		9 / 12 ASN A  33
GLY A  37
GLN A  39
TRP A  69
MET A  70
CYH A 205
THR A 208
PHE A 219
LEU A 223
 1CA  A 249 (-3.0A)
None
1CA  A 249 (-3.0A)
None
1CA  A 249 ( 3.8A)
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
None
 0.98A 1m2zA-3ry9A:
35.8		 1m2zA-3ry9A:
71.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M2Z_D_DEXD401_1
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		9 / 12 ASN A  33
GLY A  36
GLN A  39
MET A  70
ARG A  80
CYH A 205
THR A 208
PHE A 219
LEU A 223
 1CA  A 249 (-3.0A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.5A)
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
None
 0.35A 1m2zD-3ry9A:
35.7		 1m2zD-3ry9A:
71.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M2Z_D_DEXD401_1
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		9 / 12 ASN A  33
GLY A  36
GLN A  39
MET A  70
ARG A  80
MET A 115
CYH A 205
THR A 208
LEU A 223
 1CA  A 249 (-3.0A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
None
 0.69A 1m2zD-3ry9A:
35.7		 1m2zD-3ry9A:
71.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1M2Z_D_DEXD401_1
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		7 / 12 ASN A  33
GLY A  37
MET A  70
CYH A 205
THR A 208
PHE A 219
LEU A 223
 1CA  A 249 (-3.0A)
None
1CA  A 249 ( 3.8A)
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
None
 0.87A 1m2zD-3ry9A:
35.7		 1m2zD-3ry9A:
71.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		7 / 12 ASN A  33
GLY A  36
GLN A  39
MET A  73
LEU A  77
ARG A  80
MET A 115
 1CA  A 249 (-3.0A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
1CA  A 249 (-3.9A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
 0.92A 1nhzA-3ry9A:
29.8		 1nhzA-3ry9A:
71.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		8 / 12 LEU A  32
GLY A  36
GLN A  39
MET A  73
LEU A  77
ARG A  80
MET A 115
LEU A 201
 1CA  A 249 (-3.9A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
1CA  A 249 (-3.9A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 ( 4.2A)
 0.64A 1nhzA-3ry9A:
29.8		 1nhzA-3ry9A:
71.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		9 / 12 LEU A  32
ASN A  33
LEU A  35
GLY A  36
GLN A  39
MET A  70
ARG A  80
MET A 115
THR A 208
 1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.4A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 (-3.2A)
 0.85A 1p93A-3ry9A:
35.2		 1p93A-3ry9A:
71.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P93_B_DEXB2999_1
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		10 / 12 ASN A  33
GLY A  36
GLN A  39
MET A  70
LEU A  77
ARG A  80
MET A 115
CYH A 205
THR A 208
PHE A 219
 1CA  A 249 (-3.0A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 0.67A 1p93B-3ry9A:
35.4		 1p93B-3ry9A:
71.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P93_B_DEXB2999_1
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		6 / 12 ASN A  33
GLY A  37
MET A  70
CYH A 205
THR A 208
PHE A 219
 1CA  A 249 (-3.0A)
None
1CA  A 249 ( 3.8A)
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 1.04A 1p93B-3ry9A:
35.4		 1p93B-3ry9A:
71.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P93_C_DEXC3999_1
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		10 / 12 ASN A  33
GLY A  36
GLN A  39
MET A  70
LEU A  77
ARG A  80
MET A 115
LEU A 201
CYH A 205
THR A 208
 1CA  A 249 (-3.0A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 ( 4.2A)
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
 0.78A 1p93C-3ry9A:
35.1		 1p93C-3ry9A:
71.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P93_C_DEXC3999_1
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		5 / 12 ASN A  33
GLY A  37
MET A  70
CYH A 205
THR A 208
 1CA  A 249 (-3.0A)
None
1CA  A 249 ( 3.8A)
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
 1.09A 1p93C-3ry9A:
35.1		 1p93C-3ry9A:
71.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P93_D_DEXD4999_1
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		10 / 12 ASN A  33
GLY A  36
GLN A  39
MET A  70
ARG A  80
PHE A  92
MET A 115
CYH A 205
THR A 208
PHE A 219
 1CA  A 249 (-3.0A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.5A)
None
1CA  A 249 (-3.6A)
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 0.76A 1p93D-3ry9A:
35.2		 1p93D-3ry9A:
71.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P93_D_DEXD4999_1
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		6 / 12 ASN A  33
GLY A  37
MET A  70
CYH A 205
THR A 208
PHE A 219
 1CA  A 249 (-3.0A)
None
1CA  A 249 ( 3.8A)
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 1.06A 1p93D-3ry9A:
35.2		 1p93D-3ry9A:
71.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1P93_D_DEXD4999_2
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		4 / 5 LEU A  32
TRP A  69
MET A  73
LEU A  77
 1CA  A 249 (-3.9A)
None
1CA  A 249 (-3.9A)
1CA  A 249 ( 4.1A)
 0.68A 1p93D-3ry9A:
35.2		 1p93D-3ry9A:
71.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_C_DESC500_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		5 / 12 LEU A  29
LEU A  32
LEU A  35
MET A  70
ARG A  80
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 ( 4.4A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.5A)
 0.45A 1s9pC-3ry9A:
26.8		 1s9pC-3ry9A:
28.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_D_DESD600_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		5 / 12 LEU A  29
LEU A  32
MET A  70
ARG A  80
LEU A 111
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.5A)
None
 0.81A 1s9pD-3ry9A:
28.5		 1s9pD-3ry9A:
28.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		5 / 12 LEU A  29
ASN A  33
MET A  70
LEU A 111
CYH A 205
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
None
1CA  A 249 (-4.0A)
 0.84A 1sqnA-3ry9A:
36.4		 1sqnA-3ry9A:
61.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		9 / 12 LEU A  29
LEU A  32
ASN A  33
LEU A  35
GLN A  39
MET A  70
MET A  73
MET A 115
CYH A 205
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.4A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.6A)
1CA  A 249 (-4.0A)
 0.47A 1sqnA-3ry9A:
36.4		 1sqnA-3ry9A:
61.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		5 / 12 LEU A  35
LEU A  32
LEU A  29
LEU A  77
MET A 115
 1CA  A 249 ( 4.4A)
1CA  A 249 (-3.9A)
1CA  A 249 ( 3.8A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.6A)
 1.28A 1sqnA-3ry9A:
36.4		 1sqnA-3ry9A:
61.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		8 / 12 LEU A  29
ASN A  33
GLN A  39
MET A  70
LEU A 111
MET A 115
LEU A 201
CYH A 205
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.0A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
None
1CA  A 249 (-3.6A)
1CA  A 249 ( 4.2A)
1CA  A 249 (-4.0A)
 0.79A 1sqnB-3ry9A:
36.9		 1sqnB-3ry9A:
61.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		10 / 12 LEU A  29
LEU A  32
ASN A  33
LEU A  35
GLN A  39
MET A  70
MET A  73
MET A 115
LEU A 201
CYH A 205
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.4A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.6A)
1CA  A 249 ( 4.2A)
1CA  A 249 (-4.0A)
 0.56A 1sqnB-3ry9A:
36.9		 1sqnB-3ry9A:
61.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		6 / 12 LEU A  35
LEU A  32
LEU A  29
LEU A  77
MET A 115
LEU A  90
 1CA  A 249 ( 4.4A)
1CA  A 249 (-3.9A)
1CA  A 249 ( 3.8A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.6A)
None
 1.23A 1sqnB-3ry9A:
36.9		 1sqnB-3ry9A:
61.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YA3_A_STRA1001_1
(MINERALOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		5 / 12 LEU A  28
LEU A  35
GLN A  39
LEU A  77
ARG A  80
 None
1CA  A 249 ( 4.4A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
 1.15A 1ya3A-3ry9A:
36.3		 1ya3A-3ry9A:
69.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YA3_A_STRA1001_1
(MINERALOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		11 / 12 LEU A  29
ASN A  33
LEU A  35
GLN A  39
MET A  70
LEU A  77
ARG A  80
MET A 108
MET A 115
CYH A 205
THR A 208
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.4A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 (-3.6A)
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
 0.42A 1ya3A-3ry9A:
36.3		 1ya3A-3ry9A:
69.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YA3_B_STRB2001_1
(MINERALOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		10 / 12 LEU A  29
ASN A  33
GLN A  39
MET A  70
LEU A  77
ARG A  80
MET A 108
LEU A 201
CYH A 205
THR A 208
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.0A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 ( 4.2A)
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
 0.43A 1ya3B-3ry9A:
36.9		 1ya3B-3ry9A:
69.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YA3_C_STRC3001_1
(MINERALOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		11 / 12 LEU A  29
LEU A  32
ASN A  33
LEU A  35
GLN A  39
MET A  70
ARG A  80
MET A 108
LEU A 201
CYH A 205
THR A 208
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.4A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 ( 4.2A)
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
 0.49A 1ya3C-3ry9A:
36.9		 1ya3C-3ry9A:
69.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z95_A_198A501_1
(ANDROGEN RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		7 / 12 LEU A  35
GLY A  36
GLN A  39
MET A  70
MET A  73
ARG A  80
ILE A 227
 1CA  A 249 ( 4.4A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.5A)
None
 0.59A 1z95A-3ry9A:
36.4		 1z95A-3ry9A:
54.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z95_A_198A501_2
(ANDROGEN RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		4 / 6 LEU A  32
ASN A  33
LEU A 201
ILE A 226
 1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.2A)
None
 0.57A 1z95A-3ry9A:
36.4		 1z95A-3ry9A:
54.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Z95_A_198A501_2
(ANDROGEN RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		4 / 6 LEU A  32
MET A 115
LEU A 201
ILE A 226
 1CA  A 249 (-3.9A)
1CA  A 249 (-3.6A)
1CA  A 249 ( 4.2A)
None
 0.93A 1z95A-3ry9A:
36.4		 1z95A-3ry9A:
54.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZUC_A_T98A201_1
(PROGESTERONE
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		7 / 10 ASN A  33
GLN A  39
LEU A  77
ARG A  80
LEU A 111
THR A 208
PHE A 219
 1CA  A 249 (-3.0A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
None
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 0.73A 1zucA-3ry9A:
36.7		 1zucA-3ry9A:
62.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZUC_A_T98A201_1
(PROGESTERONE
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		8 / 10 LEU A  29
ASN A  33
GLN A  39
MET A  73
LEU A  77
ARG A  80
THR A 208
PHE A 219
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.0A)
1CA  A 249 (-3.0A)
1CA  A 249 (-3.9A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 0.50A 1zucA-3ry9A:
36.7		 1zucA-3ry9A:
62.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZUC_A_T98A201_1
(PROGESTERONE
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		5 / 10 LEU A  29
ASN A  33
LEU A  90
THR A 208
PHE A 219
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.0A)
None
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 1.12A 1zucA-3ry9A:
36.7		 1zucA-3ry9A:
62.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZUC_B_T98B202_1
(PROGESTERONE
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		9 / 12 ASN A  33
LEU A  35
GLN A  39
MET A  70
LEU A  77
ARG A  80
LEU A 111
THR A 208
PHE A 219
 1CA  A 249 (-3.0A)
1CA  A 249 ( 4.4A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
None
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 0.70A 1zucB-3ry9A:
36.5		 1zucB-3ry9A:
62.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZUC_B_T98B202_1
(PROGESTERONE
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		11 / 12 LEU A  29
LEU A  32
ASN A  33
LEU A  35
GLN A  39
MET A  70
MET A  73
LEU A  77
ARG A  80
THR A 208
PHE A 219
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.4A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 0.56A 1zucB-3ry9A:
36.5		 1zucB-3ry9A:
62.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZUC_B_T98B202_1
(PROGESTERONE
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		6 / 12 LEU A  29
LEU A  32
ASN A  33
LEU A  90
THR A 208
PHE A 219
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
None
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 1.20A 1zucB-3ry9A:
36.5		 1zucB-3ry9A:
62.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AA5_A_STRA301_1
(MINERALOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		10 / 12 ASN A  33
LEU A  35
GLN A  39
MET A  70
LEU A  77
ARG A  80
MET A 108
MET A 115
CYH A 205
THR A 208
 1CA  A 249 (-3.0A)
1CA  A 249 ( 4.4A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 (-3.6A)
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
 0.32A 2aa5A-3ry9A:
38.0		 2aa5A-3ry9A:
65.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AA5_B_STRB302_1
(MINERALOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		5 / 12 LEU A  28
LEU A  35
GLN A  39
LEU A  77
ARG A  80
 None
1CA  A 249 ( 4.4A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
 1.32A 2aa5B-3ry9A:
37.6		 2aa5B-3ry9A:
65.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AA5_B_STRB302_1
(MINERALOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		10 / 12 LEU A  29
ASN A  33
LEU A  35
GLN A  39
MET A  70
LEU A  77
ARG A  80
MET A 108
CYH A 205
THR A 208
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.4A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
 0.33A 2aa5B-3ry9A:
37.6		 2aa5B-3ry9A:
65.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AA6_A_STRA401_1
(MINERALOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		11 / 12 LEU A  32
ASN A  33
LEU A  35
GLN A  39
MET A  70
LEU A  77
ARG A  80
MET A 108
MET A 115
CYH A 205
THR A 208
 1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.4A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 (-3.6A)
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
 0.26A 2aa6A-3ry9A:
37.6		 2aa6A-3ry9A:
65.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AA6_B_STRB402_1
(MINERALOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		11 / 12 ASN A  33
LEU A  35
GLN A  39
MET A  70
LEU A  77
ARG A  80
MET A 108
MET A 115
LEU A 201
CYH A 205
THR A 208
 1CA  A 249 (-3.0A)
1CA  A 249 ( 4.4A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 (-3.6A)
1CA  A 249 ( 4.2A)
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
 0.23A 2aa6B-3ry9A:
37.5		 2aa6B-3ry9A:
65.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AB2_A_SNLA502_1
(MINERALOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		11 / 12 LEU A  29
ASN A  33
GLN A  39
MET A  70
ARG A  80
PHE A  92
MET A 108
MET A 115
CYH A 205
THR A 208
PHE A 219
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.0A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.5A)
None
1CA  A 249 (-3.6A)
1CA  A 249 (-3.6A)
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 0.33A 2ab2A-3ry9A:
37.8		 2ab2A-3ry9A:
65.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AB2_A_SNLA502_1
(MINERALOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		6 / 12 LEU A  29
PHE A  98
MET A 108
CYH A 205
THR A 208
PHE A 219
 1CA  A 249 ( 3.8A)
None
1CA  A 249 (-3.6A)
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 1.40A 2ab2A-3ry9A:
37.8		 2ab2A-3ry9A:
65.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AB2_A_SNLA502_2
(MINERALOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		5 / 6 LEU A  32
LEU A  35
LEU A  77
CYH A 112
LEU A 201
 1CA  A 249 (-3.9A)
1CA  A 249 ( 4.4A)
1CA  A 249 ( 4.1A)
None
1CA  A 249 ( 4.2A)
 0.18A 2ab2A-3ry9A:
37.8		 2ab2A-3ry9A:
65.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AB2_B_SNLB503_1
(MINERALOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		11 / 12 LEU A  29
ASN A  33
GLN A  39
MET A  70
ARG A  80
PHE A  92
MET A 108
MET A 115
CYH A 205
THR A 208
PHE A 219
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.0A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.5A)
None
1CA  A 249 (-3.6A)
1CA  A 249 (-3.6A)
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 0.35A 2ab2B-3ry9A:
37.6		 2ab2B-3ry9A:
65.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AB2_B_SNLB503_1
(MINERALOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		6 / 12 LEU A  29
PHE A  98
MET A 108
CYH A 205
THR A 208
PHE A 219
 1CA  A 249 ( 3.8A)
None
1CA  A 249 (-3.6A)
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 1.42A 2ab2B-3ry9A:
37.6		 2ab2B-3ry9A:
65.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AB2_B_SNLB503_2
(MINERALOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		4 / 5 LEU A  32
LEU A  35
LEU A  77
CYH A 112
 1CA  A 249 (-3.9A)
1CA  A 249 ( 4.4A)
1CA  A 249 ( 4.1A)
None
 0.16A 2ab2B-3ry9A:
37.6		 2ab2B-3ry9A:
65.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AM9_A_TESA1000_1
(ANDROGEN RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		8 / 12 ASN A  33
LEU A  35
TRP A  69
MET A  70
MET A  73
ARG A  80
MET A 108
LEU A 201
 1CA  A 249 (-3.0A)
1CA  A 249 ( 4.4A)
None
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 ( 4.2A)
 0.69A 2am9A-3ry9A:
37.0		 2am9A-3ry9A:
52.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AM9_A_TESA1000_1
(ANDROGEN RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		6 / 12 LEU A  35
GLN A  39
TRP A  69
MET A  70
MET A  73
ARG A  80
 1CA  A 249 ( 4.4A)
1CA  A 249 (-3.0A)
None
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.5A)
 0.86A 2am9A-3ry9A:
37.0		 2am9A-3ry9A:
52.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OAX_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		5 / 12 LEU A  28
LEU A  35
GLN A  39
LEU A  77
ARG A  80
 None
1CA  A 249 ( 4.4A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
 1.21A 2oaxA-3ry9A:
36.8		 2oaxA-3ry9A:
69.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OAX_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		12 / 12 LEU A  29
ASN A  33
LEU A  35
GLN A  39
MET A  70
LEU A  77
ARG A  80
MET A 108
LEU A 201
CYH A 205
THR A 208
PHE A 219
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.4A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 ( 4.2A)
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 0.42A 2oaxA-3ry9A:
36.8		 2oaxA-3ry9A:
69.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OAX_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		6 / 12 LEU A  29
ASN A  33
LEU A  90
CYH A 205
THR A 208
PHE A 219
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.0A)
None
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 1.16A 2oaxA-3ry9A:
36.8		 2oaxA-3ry9A:
69.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OAX_B_SNLB2001_1
(MINERALOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		5 / 12 LEU A  28
LEU A  35
GLN A  39
LEU A  77
ARG A  80
 None
1CA  A 249 ( 4.4A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
 1.19A 2oaxB-3ry9A:
37.0		 2oaxB-3ry9A:
69.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OAX_B_SNLB2001_1
(MINERALOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		11 / 12 LEU A  29
ASN A  33
LEU A  35
GLN A  39
MET A  70
LEU A  77
ARG A  80
LEU A 201
CYH A 205
THR A 208
PHE A 219
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.4A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
1CA  A 249 ( 4.2A)
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 0.33A 2oaxB-3ry9A:
37.0		 2oaxB-3ry9A:
69.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OAX_B_SNLB2001_1
(MINERALOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		5 / 12 LEU A  29
ASN A  33
LEU A  90
THR A 208
PHE A 219
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.0A)
None
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 1.23A 2oaxB-3ry9A:
37.0		 2oaxB-3ry9A:
69.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OAX_C_SNLC3001_1
(MINERALOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		11 / 12 LEU A  29
ASN A  33
GLN A  39
TRP A  69
MET A  70
LEU A  77
ARG A  80
MET A 108
LEU A 201
THR A 208
PHE A 219
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.0A)
1CA  A 249 (-3.0A)
None
1CA  A 249 ( 3.8A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 ( 4.2A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 0.42A 2oaxC-3ry9A:
36.6		 2oaxC-3ry9A:
69.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OAX_D_SNLD4001_1
(MINERALOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		5 / 12 LEU A  28
LEU A  35
GLN A  39
LEU A  77
ARG A  80
 None
1CA  A 249 ( 4.4A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
 1.30A 2oaxD-3ry9A:
37.0		 2oaxD-3ry9A:
69.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OAX_D_SNLD4001_1
(MINERALOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		11 / 12 LEU A  29
ASN A  33
LEU A  35
GLN A  39
TRP A  69
MET A  70
LEU A  77
ARG A  80
MET A 108
LEU A 201
PHE A 219
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.4A)
1CA  A 249 (-3.0A)
None
1CA  A 249 ( 3.8A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 ( 4.2A)
1CA  A 249 (-4.3A)
 0.34A 2oaxD-3ry9A:
37.0		 2oaxD-3ry9A:
69.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OAX_E_SNLE5001_1
(MINERALOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		5 / 12 LEU A  28
LEU A  35
GLN A  39
LEU A  77
ARG A  80
 None
1CA  A 249 ( 4.4A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
 1.26A 2oaxE-3ry9A:
36.6		 2oaxE-3ry9A:
69.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OAX_E_SNLE5001_1
(MINERALOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		11 / 12 LEU A  29
ASN A  33
LEU A  35
GLN A  39
MET A  70
LEU A  77
ARG A  80
MET A 108
LEU A 201
CYH A 205
PHE A 219
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.4A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 ( 4.2A)
1CA  A 249 (-4.0A)
1CA  A 249 (-4.3A)
 0.49A 2oaxE-3ry9A:
36.6		 2oaxE-3ry9A:
69.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OAX_F_SNLF6001_1
(MINERALOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		11 / 12 ASN A  33
LEU A  35
GLN A  39
TRP A  69
MET A  70
LEU A  77
ARG A  80
LEU A 201
CYH A 205
THR A 208
PHE A 219
 1CA  A 249 (-3.0A)
1CA  A 249 ( 4.4A)
1CA  A 249 (-3.0A)
None
1CA  A 249 ( 3.8A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
1CA  A 249 ( 4.2A)
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 0.40A 2oaxF-3ry9A:
35.9		 2oaxF-3ry9A:
69.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OAX_F_SNLF6001_1
(MINERALOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		5 / 12 ASN A  33
LEU A  90
CYH A 205
THR A 208
PHE A 219
 1CA  A 249 (-3.0A)
None
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 1.18A 2oaxF-3ry9A:
35.9		 2oaxF-3ry9A:
69.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZ7_A_CA4A1_1
(ANDROGEN RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		8 / 12 LEU A  32
ASN A  33
LEU A  35
GLY A  36
GLN A  39
ARG A  80
MET A 108
PHE A 219
 1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.4A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 (-4.3A)
 0.60A 2oz7A-3ry9A:
35.5		 2oz7A-3ry9A:
55.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZ7_A_CA4A1_2
(ANDROGEN RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		4 / 6 LEU A  29
MET A  70
MET A  73
LEU A 201
 1CA  A 249 ( 3.8A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 ( 4.2A)
 1.03A 2oz7A-3ry9A:
35.5		 2oz7A-3ry9A:
55.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZ7_A_CA4A1_2
(ANDROGEN RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		4 / 6 LEU A  29
TRP A  69
MET A  70
LEU A 201
 1CA  A 249 ( 3.8A)
None
1CA  A 249 ( 3.8A)
1CA  A 249 ( 4.2A)
 1.36A 2oz7A-3ry9A:
35.5		 2oz7A-3ry9A:
55.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZ7_A_CA4A1_2
(ANDROGEN RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		4 / 6 MET A  70
MET A  73
MET A 115
LEU A 201
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.6A)
1CA  A 249 ( 4.2A)
 0.69A 2oz7A-3ry9A:
35.5		 2oz7A-3ry9A:
55.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OZ7_A_CA4A1_2
(ANDROGEN RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		4 / 6 TRP A  69
MET A  70
MET A 115
LEU A 201
 None
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.6A)
1CA  A 249 ( 4.2A)
 1.26A 2oz7A-3ry9A:
35.5		 2oz7A-3ry9A:
55.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Q7I_A_TESA205_1
(ANDROGEN RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		8 / 12 LEU A  32
ASN A  33
LEU A  35
GLN A  39
MET A  70
MET A  73
ARG A  80
MET A 108
 1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.4A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
 0.48A 2q7iA-3ry9A:
36.9		 2q7iA-3ry9A:
53.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Q7J_A_TESA203_1
(ANDROGEN RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		9 / 12 LEU A  29
ASN A  33
LEU A  35
GLN A  39
TRP A  69
MET A  70
MET A  73
ARG A  80
MET A 108
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.4A)
1CA  A 249 (-3.0A)
None
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
 0.67A 2q7jA-3ry9A:
36.9		 2q7jA-3ry9A:
53.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Q7K_A_TESA304_1
(ANDROGEN RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		8 / 12 LEU A  32
ASN A  33
LEU A  35
GLN A  39
MET A  70
ARG A  80
MET A 108
LEU A 201
 1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.4A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 ( 4.2A)
 0.61A 2q7kA-3ry9A:
37.1		 2q7kA-3ry9A:
53.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Q7L_A_TESA155_1
(ANDROGEN RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		5 / 12 ASN A  33
GLY A  37
GLN A  39
TRP A  69
ARG A  80
 1CA  A 249 (-3.0A)
None
1CA  A 249 (-3.0A)
None
1CA  A 249 (-3.5A)
 1.35A 2q7lA-3ry9A:
36.7		 2q7lA-3ry9A:
53.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Q7L_A_TESA155_1
(ANDROGEN RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		9 / 12 LEU A  32
ASN A  33
LEU A  35
GLY A  36
GLN A  39
TRP A  69
MET A  70
ARG A  80
MET A 108
 1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.4A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
None
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
 0.59A 2q7lA-3ry9A:
36.7		 2q7lA-3ry9A:
53.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		5 / 12 GLY A  36
TRP A  69
MET A  70
MET A  73
PHE A  98
 1CA  A 249 ( 4.0A)
None
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
None
 1.25A 2w8yA-3ry9A:
36.6		 2w8yA-3ry9A:
61.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		5 / 12 LEU A  28
LEU A  35
GLY A  36
GLN A  39
ARG A  80
 None
1CA  A 249 ( 4.4A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
1CA  A 249 (-3.5A)
 1.38A 2w8yA-3ry9A:
36.6		 2w8yA-3ry9A:
61.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		7 / 12 LEU A  29
GLY A  36
GLN A  39
MET A  70
ARG A  80
LEU A 111
CYH A 205
 1CA  A 249 ( 3.8A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.5A)
None
1CA  A 249 (-4.0A)
 0.76A 2w8yA-3ry9A:
36.6		 2w8yA-3ry9A:
61.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		6 / 12 LEU A  29
GLY A  37
GLN A  39
TRP A  69
MET A  70
CYH A 205
 1CA  A 249 ( 3.8A)
None
1CA  A 249 (-3.0A)
None
1CA  A 249 ( 3.8A)
1CA  A 249 (-4.0A)
 1.23A 2w8yA-3ry9A:
36.6		 2w8yA-3ry9A:
61.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		9 / 12 LEU A  29
LEU A  35
GLY A  36
GLN A  39
TRP A  69
MET A  70
MET A  73
ARG A  80
CYH A 205
 1CA  A 249 ( 3.8A)
1CA  A 249 ( 4.4A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
None
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.5A)
1CA  A 249 (-4.0A)
 0.57A 2w8yA-3ry9A:
36.6		 2w8yA-3ry9A:
61.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		10 / 12 LEU A  29
LEU A  32
ASN A  33
LEU A  35
GLN A  39
MET A  70
MET A  73
ARG A  80
MET A 115
CYH A 205
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.4A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 (-4.0A)
 0.50A 2w8yB-3ry9A:
36.7		 2w8yB-3ry9A:
61.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		5 / 12 LEU A  29
MET A  70
ARG A  80
LEU A 111
CYH A 205
 1CA  A 249 ( 3.8A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.5A)
None
1CA  A 249 (-4.0A)
 0.95A 2w8yB-3ry9A:
36.7		 2w8yB-3ry9A:
61.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		5 / 12 LEU A  35
LEU A  32
LEU A  29
LEU A  77
MET A 115
 1CA  A 249 ( 4.4A)
1CA  A 249 (-3.9A)
1CA  A 249 ( 3.8A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.6A)
 1.24A 2w8yB-3ry9A:
36.7		 2w8yB-3ry9A:
61.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YHD_A_TESA1920_1
(ANDROGEN RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		9 / 12 LEU A  29
ASN A  33
LEU A  35
GLY A  36
GLN A  39
MET A  70
MET A  73
ARG A  80
MET A 108
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.4A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
 0.54A 2yhdA-3ry9A:
36.6		 2yhdA-3ry9A:
55.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YLO_A_TESA1920_1
(ANDROGEN RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		7 / 12 LEU A  32
ASN A  33
LEU A  35
MET A  70
MET A  73
ARG A  80
PHE A 219
 1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.4A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.5A)
1CA  A 249 (-4.3A)
 0.55A 2yloA-3ry9A:
36.8		 2yloA-3ry9A:
53.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YLO_A_TESA1920_1
(ANDROGEN RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		7 / 12 LEU A  32
LEU A  35
GLN A  39
MET A  70
MET A  73
ARG A  80
PHE A 219
 1CA  A 249 (-3.9A)
1CA  A 249 ( 4.4A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.5A)
1CA  A 249 (-4.3A)
 0.72A 2yloA-3ry9A:
36.8		 2yloA-3ry9A:
53.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YLP_A_TESA1921_1
(ANDROGEN RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		8 / 11 LEU A  29
ASN A  33
LEU A  35
GLN A  39
MET A  70
MET A  73
ARG A  80
LEU A 201
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.4A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.5A)
1CA  A 249 ( 4.2A)
 0.64A 2ylpA-3ry9A:
36.9		 2ylpA-3ry9A:
53.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YLQ_A_TESA1921_1
(ANDROGEN RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		7 / 11 LEU A  29
ASN A  33
LEU A  35
GLN A  39
MET A  70
MET A  73
ARG A  80
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.4A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.5A)
 0.56A 2ylqA-3ry9A:
37.0		 2ylqA-3ry9A:
53.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CLD_A_GW6A1_1
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		11 / 12 ASN A  33
GLY A  36
GLN A  39
MET A  70
LEU A  77
ARG A  80
CYH A 112
LEU A 201
CYH A 205
THR A 208
PHE A 219
 1CA  A 249 (-3.0A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
None
1CA  A 249 ( 4.2A)
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 0.46A 3cldA-3ry9A:
36.0		 3cldA-3ry9A:
71.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CLD_A_GW6A1_1
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		6 / 12 ASN A  33
GLY A  37
MET A  70
CYH A 205
THR A 208
PHE A 219
 1CA  A 249 (-3.0A)
None
1CA  A 249 ( 3.8A)
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 1.00A 3cldA-3ry9A:
36.0		 3cldA-3ry9A:
71.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CLD_A_GW6A1_2
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		5 / 9 LEU A  32
LEU A  35
TRP A  69
MET A  73
ALA A  74
 1CA  A 249 (-3.9A)
1CA  A 249 ( 4.4A)
None
1CA  A 249 (-3.9A)
1CA  A 249 ( 4.7A)
 0.59A 3cldA-3ry9A:
36.0		 3cldA-3ry9A:
71.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CLD_A_GW6A1_2
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		5 / 9 LEU A  32
LEU A  35
TRP A  69
MET A  73
MET A 115
 1CA  A 249 (-3.9A)
1CA  A 249 ( 4.4A)
None
1CA  A 249 (-3.9A)
1CA  A 249 (-3.6A)
 0.73A 3cldA-3ry9A:
36.0		 3cldA-3ry9A:
71.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CLD_B_GW6B2_1
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		10 / 12 ASN A  33
GLY A  36
GLN A  39
MET A  70
ARG A  80
CYH A 112
LEU A 201
CYH A 205
THR A 208
PHE A 219
 1CA  A 249 (-3.0A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.5A)
None
1CA  A 249 ( 4.2A)
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 0.48A 3cldB-3ry9A:
35.9		 3cldB-3ry9A:
71.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CLD_B_GW6B2_1
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		6 / 12 ASN A  33
GLY A  37
MET A  70
CYH A 205
THR A 208
PHE A 219
 1CA  A 249 (-3.0A)
None
1CA  A 249 ( 3.8A)
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 0.99A 3cldB-3ry9A:
35.9		 3cldB-3ry9A:
71.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		4 / 8 LEU A  32
MET A  73
ALA A  74
LEU A  77
 1CA  A 249 (-3.9A)
1CA  A 249 (-3.9A)
1CA  A 249 ( 4.7A)
1CA  A 249 ( 4.1A)
 0.50A 3cldB-3ry9A:
35.9		 3cldB-3ry9A:
71.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		4 / 8 LEU A  32
MET A  73
LEU A  77
MET A 115
 1CA  A 249 (-3.9A)
1CA  A 249 (-3.9A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.6A)
 0.64A 3cldB-3ry9A:
35.9		 3cldB-3ry9A:
71.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3D90_A_NOGA1001_1
(PROGESTERONE
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		6 / 12 LEU A  29
ASN A  33
MET A  70
ARG A  80
LEU A 111
CYH A 205
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.5A)
None
1CA  A 249 (-4.0A)
 0.80A 3d90A-3ry9A:
35.8		 3d90A-3ry9A:
62.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3D90_A_NOGA1001_1
(PROGESTERONE
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		10 / 12 LEU A  29
LEU A  32
ASN A  33
LEU A  35
GLN A  39
MET A  70
MET A  73
ARG A  80
MET A 115
CYH A 205
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.4A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 (-4.0A)
 0.56A 3d90A-3ry9A:
35.8		 3d90A-3ry9A:
62.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3D90_A_NOGA1001_1
(PROGESTERONE
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		5 / 12 LEU A  35
LEU A  32
LEU A  29
LEU A  77
MET A 115
 1CA  A 249 ( 4.4A)
1CA  A 249 (-3.9A)
1CA  A 249 ( 3.8A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.6A)
 1.25A 3d90A-3ry9A:
35.8		 3d90A-3ry9A:
62.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3D90_B_NOGB2001_1
(PROGESTERONE
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		11 / 12 LEU A  29
LEU A  32
ASN A  33
LEU A  35
GLN A  39
MET A  70
LEU A  77
ARG A  80
LEU A 111
MET A 115
CYH A 205
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.4A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
None
1CA  A 249 (-3.6A)
1CA  A 249 (-4.0A)
 0.74A 3d90B-3ry9A:
36.3		 3d90B-3ry9A:
62.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3D90_B_NOGB2001_1
(PROGESTERONE
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		5 / 12 LEU A  32
LEU A  96
LEU A  90
LEU A 201
MET A 115
 1CA  A 249 (-3.9A)
None
None
1CA  A 249 ( 4.2A)
1CA  A 249 (-3.6A)
 1.30A 3d90B-3ry9A:
36.3		 3d90B-3ry9A:
62.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		3 / 3 ASP A  60
LEU A  64
GLN A 230
 None
 0.80A 3g4lA-3ry9A:
undetectable		 3g4lA-3ry9A:
19.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GN8_A_DEXA247_1
(GLUCOCORTICOID
RECEPTOR 2)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		6 / 12 ASN A  33
GLY A  37
TRP A  69
CYH A 205
THR A 208
VAL A 217
 1CA  A 249 (-3.0A)
None
None
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.9A)
 0.92A 3gn8A-3ry9A:
36.4		 3gn8A-3ry9A:
84.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GN8_A_DEXA247_1
(GLUCOCORTICOID
RECEPTOR 2)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		10 / 12 LEU A  32
ASN A  33
GLY A  36
GLN A  39
TRP A  69
MET A  70
ARG A  80
CYH A 205
THR A 208
VAL A 217
 1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
None
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.5A)
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.9A)
 0.43A 3gn8A-3ry9A:
36.4		 3gn8A-3ry9A:
84.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GN8_A_DEXA247_1
(GLUCOCORTICOID
RECEPTOR 2)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		10 / 12 LEU A  32
ASN A  33
GLY A  36
GLN A  39
TRP A  69
MET A  70
ARG A  80
MET A 115
CYH A 205
THR A 208
 1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
None
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
 0.78A 3gn8A-3ry9A:
36.4		 3gn8A-3ry9A:
84.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GN8_B_DEXB247_1
(GLUCOCORTICOID
RECEPTOR 2)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		8 / 12 ASN A  33
GLY A  37
TRP A  69
MET A  70
CYH A 205
THR A 208
VAL A 217
PHE A 219
 1CA  A 249 (-3.0A)
None
None
1CA  A 249 ( 3.8A)
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.9A)
1CA  A 249 (-4.3A)
 0.88A 3gn8B-3ry9A:
36.2		 3gn8B-3ry9A:
84.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GN8_B_DEXB247_1
(GLUCOCORTICOID
RECEPTOR 2)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		11 / 12 LEU A  32
ASN A  33
GLY A  36
GLN A  39
TRP A  69
MET A  70
ARG A  80
CYH A 205
THR A 208
VAL A 217
PHE A 219
 1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
None
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.5A)
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.9A)
1CA  A 249 (-4.3A)
 0.42A 3gn8B-3ry9A:
36.2		 3gn8B-3ry9A:
84.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GN8_B_DEXB247_1
(GLUCOCORTICOID
RECEPTOR 2)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		11 / 12 LEU A  32
ASN A  33
GLY A  36
GLN A  39
TRP A  69
MET A  70
ARG A  80
MET A 115
CYH A 205
THR A 208
PHE A 219
 1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
None
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 0.75A 3gn8B-3ry9A:
36.2		 3gn8B-3ry9A:
84.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		8 / 12 LEU A  32
ASN A  33
GLY A  36
GLN A  39
MET A  70
ARG A  80
MET A 115
LEU A 201
 1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 ( 4.2A)
 0.80A 3h52A-3ry9A:
26.2		 3h52A-3ry9A:
70.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_B_486B1_1
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		5 / 10 LEU A  32
TRP A  69
MET A  70
MET A  73
LEU A 201
 1CA  A 249 (-3.9A)
None
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 ( 4.2A)
 0.70A 3h52B-3ry9A:
27.8		 3h52B-3ry9A:
70.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_B_486B1_1
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		5 / 10 LEU A  35
TRP A  69
MET A  70
MET A 222
LEU A 223
 1CA  A 249 ( 4.4A)
None
1CA  A 249 ( 3.8A)
None
None
 1.29A 3h52B-3ry9A:
27.8		 3h52B-3ry9A:
70.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		6 / 12 GLN A  39
LEU A  77
ARG A  80
MET A 108
CYH A 112
MET A 115
 1CA  A 249 (-3.0A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
None
1CA  A 249 (-3.6A)
 1.28A 3h52B-3ry9A:
27.8		 3h52B-3ry9A:
70.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		6 / 12 GLY A  36
GLN A  39
LEU A  77
ARG A  80
MET A 115
ILE A 227
 1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
None
 1.39A 3h52B-3ry9A:
27.8		 3h52B-3ry9A:
70.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_B_486B1_2
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		9 / 12 GLY A  36
GLY A  37
GLN A  39
LEU A  77
ARG A  80
CYH A 112
MET A 115
CYH A 205
ILE A 226
 1CA  A 249 ( 4.0A)
None
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
None
1CA  A 249 (-3.6A)
1CA  A 249 (-4.0A)
None
 0.85A 3h52B-3ry9A:
27.8		 3h52B-3ry9A:
70.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_C_486C4_1
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		8 / 12 GLY A  36
GLN A  39
TRP A  69
MET A  70
LEU A  77
ARG A  80
PHE A  92
MET A 115
 1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
None
1CA  A 249 ( 3.8A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
None
1CA  A 249 (-3.6A)
 0.74A 3h52C-3ry9A:
25.6		 3h52C-3ry9A:
70.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_C_486C4_1
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		7 / 12 LEU A  32
GLY A  36
GLN A  39
TRP A  69
ARG A  80
PHE A  92
MET A 115
 1CA  A 249 (-3.9A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
None
1CA  A 249 (-3.5A)
None
1CA  A 249 (-3.6A)
 0.97A 3h52C-3ry9A:
25.6		 3h52C-3ry9A:
70.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_D_486D2_1
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		6 / 12 GLY A  36
GLN A  39
LEU A  77
ARG A  80
MET A 108
MET A 115
 1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 (-3.6A)
 1.05A 3h52D-3ry9A:
27.0		 3h52D-3ry9A:
70.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_D_486D2_1
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		7 / 12 GLY A  36
GLN A  39
MET A  70
ARG A  80
MET A 115
LEU A 201
CYH A 205
 1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 ( 4.2A)
1CA  A 249 (-4.0A)
 1.04A 3h52D-3ry9A:
27.0		 3h52D-3ry9A:
70.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_D_486D2_1
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		7 / 12 GLY A  36
GLN A  39
MET A  70
LEU A  77
ARG A  80
MET A 115
LEU A 201
 1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 ( 4.2A)
 0.82A 3h52D-3ry9A:
27.0		 3h52D-3ry9A:
70.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3H52_D_486D2_1
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		5 / 12 LEU A  77
ARG A  80
MET A 108
MET A 115
LEU A 197
 1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 (-3.6A)
None
 1.02A 3h52D-3ry9A:
27.0		 3h52D-3ry9A:
70.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		5 / 11 LEU A  32
LEU A  35
LEU A  77
ARG A  80
MET A 108
 1CA  A 249 (-3.9A)
1CA  A 249 ( 4.4A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
 0.34A 3hm1B-3ry9A:
28.1		 3hm1B-3ry9A:
29.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MNE_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		9 / 12 ASN A  33
GLY A  36
GLN A  39
TRP A  69
MET A  70
ARG A  80
LEU A 201
THR A 208
PHE A 219
 1CA  A 249 (-3.0A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
None
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.5A)
1CA  A 249 ( 4.2A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 0.45A 3mneA-3ry9A:
35.2		 3mneA-3ry9A:
71.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MNE_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		9 / 12 ASN A  33
GLY A  36
GLN A  39
TRP A  69
MET A  70
ARG A  80
MET A 115
LEU A 201
THR A 208
 1CA  A 249 (-3.0A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
None
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 ( 4.2A)
1CA  A 249 (-3.2A)
 0.79A 3mneA-3ry9A:
35.2		 3mneA-3ry9A:
71.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MNE_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		6 / 12 ASN A  33
GLY A  37
TRP A  69
MET A  70
THR A 208
PHE A 219
 1CA  A 249 (-3.0A)
None
None
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 0.92A 3mneA-3ry9A:
35.2		 3mneA-3ry9A:
71.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		9 / 12 ASN A  33
GLY A  36
GLN A  39
MET A  70
ARG A  80
LEU A 201
CYH A 205
THR A 208
PHE A 219
 1CA  A 249 (-3.0A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.5A)
1CA  A 249 ( 4.2A)
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 0.45A 3mnoA-3ry9A:
34.8		 3mnoA-3ry9A:
71.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		6 / 12 ASN A  33
GLY A  37
MET A  70
CYH A 205
THR A 208
PHE A 219
 1CA  A 249 (-3.0A)
None
1CA  A 249 ( 3.8A)
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 0.89A 3mnoA-3ry9A:
34.8		 3mnoA-3ry9A:
71.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		6 / 12 GLY A  36
GLN A  39
MET A  70
ARG A  80
MET A 115
LEU A 201
 1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 ( 4.2A)
 0.95A 3mnoA-3ry9A:
34.8		 3mnoA-3ry9A:
71.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		9 / 12 ASN A  33
GLY A  36
GLN A  39
MET A  70
ARG A  80
LEU A 201
CYH A 205
THR A 208
PHE A 219
 1CA  A 249 (-3.0A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.5A)
1CA  A 249 ( 4.2A)
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 0.46A 3mnpA-3ry9A:
35.5		 3mnpA-3ry9A:
69.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		6 / 12 ASN A  33
GLY A  37
MET A  70
CYH A 205
THR A 208
PHE A 219
 1CA  A 249 (-3.0A)
None
1CA  A 249 ( 3.8A)
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 0.90A 3mnpA-3ry9A:
35.5		 3mnpA-3ry9A:
69.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		6 / 12 GLY A  36
GLN A  39
MET A  70
ARG A  80
MET A 115
LEU A 201
 1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 ( 4.2A)
 1.00A 3mnpA-3ry9A:
35.5		 3mnpA-3ry9A:
69.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLL_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		5 / 10 LEU A  32
LEU A  35
MET A  70
LEU A  77
ARG A  80
 1CA  A 249 (-3.9A)
1CA  A 249 ( 4.4A)
1CA  A 249 ( 3.8A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
 0.30A 3ollA-3ry9A:
27.6		 3ollA-3ry9A:
29.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		5 / 12 LEU A  32
LEU A  35
MET A  70
LEU A  77
ARG A  80
 1CA  A 249 (-3.9A)
1CA  A 249 ( 4.4A)
1CA  A 249 ( 3.8A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
 0.27A 3olsA-3ry9A:
28.6		 3olsA-3ry9A:
29.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VHU_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		11 / 12 LEU A  29
ASN A  33
GLN A  39
MET A  70
LEU A  77
ARG A  80
MET A 108
LEU A 201
CYH A 205
THR A 208
PHE A 219
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.0A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 ( 4.2A)
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 0.30A 3vhuA-3ry9A:
37.7		 3vhuA-3ry9A:
65.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3VHU_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		5 / 12 LEU A  29
ASN A  33
LEU A  90
THR A 208
PHE A 219
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.0A)
None
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 1.23A 3vhuA-3ry9A:
37.7		 3vhuA-3ry9A:
65.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZQT_A_TESA1000_1
(ANDROGEN RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		7 / 12 LEU A  29
LEU A  32
ASN A  33
LEU A  35
MET A  70
MET A  73
ARG A  80
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.4A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.5A)
 0.58A 3zqtA-3ry9A:
36.8		 3zqtA-3ry9A:
53.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZQT_A_TESA1000_1
(ANDROGEN RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		7 / 12 LEU A  29
LEU A  32
LEU A  35
GLN A  39
MET A  70
MET A  73
ARG A  80
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 ( 4.4A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.5A)
 0.70A 3zqtA-3ry9A:
36.8		 3zqtA-3ry9A:
53.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FN9_A_STRA301_1
(STEROID RECEPTOR 2)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		11 / 12 LEU A  29
LEU A  32
ASN A  33
LEU A  35
GLN A  39
MET A  70
ALA A  74
ARG A  80
MET A 108
CYH A 205
THR A 208
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.4A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 ( 4.7A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
 0.38A 4fn9A-3ry9A:
38.0		 4fn9A-3ry9A:
81.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FN9_B_STRB301_1
(STEROID RECEPTOR 2)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		10 / 12 LEU A  29
LEU A  32
ASN A  33
LEU A  35
GLN A  39
TRP A  69
MET A  70
ARG A  80
MET A 108
THR A 208
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.4A)
1CA  A 249 (-3.0A)
None
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 (-3.2A)
 0.46A 4fn9B-3ry9A:
37.6		 4fn9B-3ry9A:
81.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HLW_A_TESA1001_1
(ANDROGEN RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		5 / 12 ASN A  33
GLY A  37
GLN A  39
TRP A  69
ARG A  80
 1CA  A 249 (-3.0A)
None
1CA  A 249 (-3.0A)
None
1CA  A 249 (-3.5A)
 1.38A 4hlwA-3ry9A:
36.7		 4hlwA-3ry9A:
53.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4HLW_A_TESA1001_1
(ANDROGEN RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		8 / 12 LEU A  32
ASN A  33
GLY A  36
GLN A  39
TRP A  69
MET A  70
MET A  73
ARG A  80
 1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
None
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.5A)
 0.61A 4hlwA-3ry9A:
36.7		 4hlwA-3ry9A:
53.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		5 / 12 LEU A  32
LEU A  35
MET A  70
LEU A  77
ARG A  80
 1CA  A 249 (-3.9A)
1CA  A 249 ( 4.4A)
1CA  A 249 ( 3.8A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
 0.30A 4j24A-3ry9A:
28.5		 4j24A-3ry9A:
29.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		8 / 9 THR A  25
LEU A  29
LEU A 111
GLN A 203
PHE A 204
TYR A 207
THR A 208
LEU A 215
 None
1CA  A 249 ( 3.8A)
None
None
1CA  A 249 (-4.8A)
None
1CA  A 249 (-3.2A)
None
 0.49A 4ltwA-3ry9A:
38.4		 4ltwA-3ry9A:
81.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LTW_A_STRA301_1
(ANCESTRAL STEROID
RECEPTOR 2)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		10 / 12 LEU A  29
LEU A  32
ASN A  33
LEU A  35
GLN A  39
MET A  70
ARG A  80
MET A 108
LEU A 201
CYH A 205
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.4A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 ( 4.2A)
1CA  A 249 (-4.0A)
 0.28A 4ltwA-3ry9A:
38.4		 4ltwA-3ry9A:
81.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LTW_A_STRA301_2
(ANCESTRAL STEROID
RECEPTOR 2)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		8 / 8 TRP A  69
MET A  73
ALA A  74
MET A 115
PHE A 204
THR A 208
VAL A 217
PHE A 219
 None
1CA  A 249 (-3.9A)
1CA  A 249 ( 4.7A)
1CA  A 249 (-3.6A)
1CA  A 249 (-4.8A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.9A)
1CA  A 249 (-4.3A)
 0.51A 4ltwA-3ry9A:
38.4		 4ltwA-3ry9A:
81.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		3 / 3 LEU A 166
ILE A 170
ARG A 173
 None
 0.66A 4mk4B-3ry9A:
undetectable		 4mk4B-3ry9A:
21.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OJB_A_198A1001_1
(ANDROGEN RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		6 / 12 LEU A  35
GLY A  36
GLN A  39
MET A  70
MET A  73
ARG A  80
 1CA  A 249 ( 4.4A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.5A)
 0.55A 4ojbA-3ry9A:
36.5		 4ojbA-3ry9A:
54.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OJB_A_198A1001_2
(ANDROGEN RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		4 / 7 ASN A  33
LEU A 201
ILE A 226
ILE A 227
 1CA  A 249 (-3.0A)
1CA  A 249 ( 4.2A)
None
None
 0.45A 4ojbA-3ry9A:
36.5		 4ojbA-3ry9A:
54.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OJB_A_198A1001_2
(ANDROGEN RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		4 / 7 LEU A  32
ASN A  33
ILE A 226
ILE A 227
 1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
None
None
 0.51A 4ojbA-3ry9A:
36.5		 4ojbA-3ry9A:
54.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OK1_A_198A1001_1
(ANDROGEN RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		7 / 12 LEU A  32
LEU A  35
GLY A  36
GLN A  39
MET A  70
ARG A  80
ILE A 227
 1CA  A 249 (-3.9A)
1CA  A 249 ( 4.4A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.5A)
None
 0.61A 4ok1A-3ry9A:
36.1		 4ok1A-3ry9A:
54.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OK1_A_198A1001_2
(ANDROGEN RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		4 / 8 ASN A  33
MET A  73
LEU A 201
ILE A 226
 1CA  A 249 (-3.0A)
1CA  A 249 (-3.9A)
1CA  A 249 ( 4.2A)
None
 0.84A 4ok1A-3ry9A:
36.1		 4ok1A-3ry9A:
54.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OKB_A_198A1002_1
(ANDROGEN RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		7 / 12 LEU A  35
GLY A  36
GLN A  39
MET A  70
MET A  73
ARG A  80
ILE A 227
 1CA  A 249 ( 4.4A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.5A)
None
 0.70A 4okbA-3ry9A:
36.3		 4okbA-3ry9A:
54.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OKB_A_198A1002_2
(ANDROGEN RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		4 / 6 LEU A  32
ASN A  33
MET A 115
LEU A 201
 1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
1CA  A 249 (-3.6A)
1CA  A 249 ( 4.2A)
 0.95A 4okbA-3ry9A:
36.3		 4okbA-3ry9A:
54.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OKB_A_198A1002_2
(ANDROGEN RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		4 / 6 LEU A  77
MET A 108
LEU A  32
MET A  40
 1CA  A 249 ( 4.1A)
1CA  A 249 (-3.6A)
1CA  A 249 (-3.9A)
None
 1.19A 4okbA-3ry9A:
36.3		 4okbA-3ry9A:
54.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OKT_A_198A1001_1
(ANDROGEN RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		8 / 12 LEU A  32
LEU A  35
GLY A  36
GLN A  39
MET A  70
ARG A  80
MET A 115
ILE A 227
 1CA  A 249 (-3.9A)
1CA  A 249 ( 4.4A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
None
 0.67A 4oktA-3ry9A:
35.8		 4oktA-3ry9A:
54.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OKW_A_198A1001_1
(ANDROGEN RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		7 / 12 LEU A  35
GLY A  36
GLN A  39
MET A  70
MET A  73
ARG A  80
ILE A 227
 1CA  A 249 ( 4.4A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.5A)
None
 0.58A 4okwA-3ry9A:
36.4		 4okwA-3ry9A:
54.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OKX_A_198A1002_1
(ANDROGEN RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		6 / 12 LEU A  35
GLY A  36
GLN A  39
MET A  70
MET A  73
ARG A  80
 1CA  A 249 ( 4.4A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.5A)
 0.54A 4okxA-3ry9A:
36.5		 4okxA-3ry9A:
54.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		4 / 6 LEU A  32
ASN A  33
LEU A 201
ILE A 227
 1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.2A)
None
 0.64A 4okxA-3ry9A:
36.5		 4okxA-3ry9A:
54.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		4 / 6 LEU A  32
MET A 115
LEU A 201
ILE A 227
 1CA  A 249 (-3.9A)
1CA  A 249 (-3.6A)
1CA  A 249 ( 4.2A)
None
 0.93A 4okxA-3ry9A:
36.5		 4okxA-3ry9A:
54.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OLM_A_198A1001_1
(ANDROGEN RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		7 / 12 LEU A  32
LEU A  35
GLY A  36
GLN A  39
MET A  70
MET A  73
ARG A  80
 1CA  A 249 (-3.9A)
1CA  A 249 ( 4.4A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.5A)
 0.56A 4olmA-3ry9A:
35.7		 4olmA-3ry9A:
54.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OLM_A_198A1001_2
(ANDROGEN RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		4 / 6 ASN A  33
MET A 115
ILE A 226
ILE A 227
 1CA  A 249 (-3.0A)
1CA  A 249 (-3.6A)
None
None
 0.78A 4olmA-3ry9A:
35.7		 4olmA-3ry9A:
54.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		9 / 12 LEU A  32
ASN A  33
GLY A  36
GLN A  39
MET A  70
LEU A  77
ARG A  80
THR A 208
PHE A 219
 1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 0.56A 4p6xA-3ry9A:
36.1		 4p6xA-3ry9A:
71.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P6X_C_HCYC900_1
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		8 / 11 ASN A  33
LEU A  35
GLN A  39
TRP A  69
MET A  70
MET A  73
ARG A  80
THR A 208
 1CA  A 249 (-3.0A)
1CA  A 249 ( 4.4A)
1CA  A 249 (-3.0A)
None
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.2A)
 0.58A 4p6xC-3ry9A:
36.6		 4p6xC-3ry9A:
71.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		10 / 12 LEU A  32
ASN A  33
GLY A  36
GLN A  39
MET A  70
MET A  73
LEU A  77
ARG A  80
THR A 208
PHE A 219
 1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 0.58A 4p6xE-3ry9A:
36.0		 4p6xE-3ry9A:
71.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P6X_G_HCYG900_1
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		9 / 12 ASN A  33
GLY A  36
GLN A  39
TRP A  69
MET A  70
LEU A  77
ARG A  80
MET A 115
THR A 208
 1CA  A 249 (-3.0A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
None
1CA  A 249 ( 3.8A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 (-3.2A)
 0.72A 4p6xG-3ry9A:
36.0		 4p6xG-3ry9A:
71.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P6X_G_HCYG900_1
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		9 / 12 ASN A  33
GLY A  36
GLN A  39
TRP A  69
MET A  70
LEU A  77
ARG A  80
THR A 208
PHE A 219
 1CA  A 249 (-3.0A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
None
1CA  A 249 ( 3.8A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 0.42A 4p6xG-3ry9A:
36.0		 4p6xG-3ry9A:
71.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P6X_G_HCYG900_1
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		5 / 12 ASN A  33
GLY A  37
TRP A  69
THR A 208
PHE A 219
 1CA  A 249 (-3.0A)
None
None
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 0.98A 4p6xG-3ry9A:
36.0		 4p6xG-3ry9A:
71.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		6 / 12 ASN A  33
GLY A  37
GLN A  39
MET A  70
THR A 208
PHE A 219
 1CA  A 249 (-3.0A)
None
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 1.15A 4p6xI-3ry9A:
36.1		 4p6xI-3ry9A:
71.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		10 / 12 LEU A  32
ASN A  33
GLY A  36
GLN A  39
MET A  70
LEU A  77
ARG A  80
MET A 115
THR A 208
PHE A 219
 1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 0.76A 4p6xI-3ry9A:
36.1		 4p6xI-3ry9A:
71.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P6X_K_HCYK900_1
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		9 / 12 ASN A  33
GLY A  36
GLN A  39
TRP A  69
MET A  70
ARG A  80
MET A 115
THR A 208
PHE A 219
 1CA  A 249 (-3.0A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
None
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 0.78A 4p6xK-3ry9A:
36.6		 4p6xK-3ry9A:
71.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4P6X_K_HCYK900_1
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		5 / 12 ASN A  33
GLY A  37
TRP A  69
THR A 208
PHE A 219
 1CA  A 249 (-3.0A)
None
None
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 0.98A 4p6xK-3ry9A:
36.6		 4p6xK-3ry9A:
71.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UDA_A_DEXA1985_1
(MINERALOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		10 / 12 LEU A  29
ASN A  33
GLN A  39
MET A  70
ARG A  80
MET A 108
MET A 115
LEU A 201
CYH A 205
PHE A 219
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.0A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 (-3.6A)
1CA  A 249 ( 4.2A)
1CA  A 249 (-4.0A)
1CA  A 249 (-4.3A)
 0.38A 4udaA-3ry9A:
38.2		 4udaA-3ry9A:
70.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		4 / 6 LEU A  28
PHE A 204
THR A 208
VAL A 217
 None
1CA  A 249 (-4.8A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.9A)
 1.08A 4udaA-3ry9A:
38.2		 4udaA-3ry9A:
70.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		6 / 6 LEU A  32
TRP A  69
LEU A 111
PHE A 204
THR A 208
VAL A 217
 1CA  A 249 (-3.9A)
None
None
1CA  A 249 (-4.8A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.9A)
 0.56A 4udaA-3ry9A:
38.2		 4udaA-3ry9A:
70.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UDC_A_DEXA1778_1
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		5 / 12 ASN A  33
GLY A  37
TRP A  69
THR A 208
PHE A 219
 1CA  A 249 (-3.0A)
None
None
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 1.00A 4udcA-3ry9A:
36.2		 4udcA-3ry9A:
71.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UDC_A_DEXA1778_1
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		10 / 12 LEU A  32
ASN A  33
GLY A  36
GLN A  39
TRP A  69
MET A  70
ARG A  80
MET A 115
THR A 208
PHE A 219
 1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
None
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 0.78A 4udcA-3ry9A:
36.2		 4udcA-3ry9A:
71.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		3 / 3 MET A 194
GLN A 230
TYR A  67
 None
 1.07A 4udcA-3ry9A:
36.2		 4udcA-3ry9A:
71.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_A_DESA601_1
(ESTROGEN RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		5 / 12 LEU A  32
LEU A  77
ARG A  80
MET A 108
LEU A 223
 1CA  A 249 (-3.9A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
None
 0.65A 4zn7A-3ry9A:
27.8		 4zn7A-3ry9A:
29.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MWY_A_YNUA1101_0
(MINERALOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		8 / 12 LEU A  29
LEU A  32
ASN A  33
TRP A  69
MET A  70
LEU A  77
MET A 108
LEU A 201
 1CA  A 249 ( 3.8A)
1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
None
1CA  A 249 ( 3.8A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.6A)
1CA  A 249 ( 4.2A)
 0.34A 5mwyA-3ry9A:
38.3		 5mwyA-3ry9A:
59.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MWY_A_YNUA1101_0
(MINERALOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		5 / 12 TRP A  69
MET A  70
LEU A  77
MET A 115
LEU A 201
 None
1CA  A 249 ( 3.8A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.6A)
1CA  A 249 ( 4.2A)
 0.86A 5mwyA-3ry9A:
38.3		 5mwyA-3ry9A:
59.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MWY_A_YNUA1101_1
(MINERALOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		6 / 6 GLN A  39
ARG A  80
PHE A  92
CYH A 205
THR A 208
PHE A 219
 1CA  A 249 (-3.0A)
1CA  A 249 (-3.5A)
None
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 0.29A 5mwyA-3ry9A:
38.1		 5mwyA-3ry9A:
59.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MWY_A_YNUA1101_1
(MINERALOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		4 / 6 PHE A  98
CYH A 205
THR A 208
PHE A 219
 None
1CA  A 249 (-4.0A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 1.33A 5mwyA-3ry9A:
38.1		 5mwyA-3ry9A:
59.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NFP_A_8W5A804_1
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		9 / 12 ASN A  33
GLY A  36
GLN A  39
MET A  70
ARG A  80
CYH A 112
MET A 115
THR A 208
PHE A 219
 1CA  A 249 (-3.0A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.5A)
None
1CA  A 249 (-3.6A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 0.61A 5nfpA-3ry9A:
36.6		 5nfpA-3ry9A:
66.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NFP_A_8W5A804_1
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		5 / 12 ASN A  33
GLY A  37
MET A  70
THR A 208
PHE A 219
 1CA  A 249 (-3.0A)
None
1CA  A 249 ( 3.8A)
1CA  A 249 (-3.2A)
1CA  A 249 (-4.3A)
 1.00A 5nfpA-3ry9A:
36.6		 5nfpA-3ry9A:
66.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_A_ESTA601_1
(ESTROGEN RECEPTOR
BETA)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		5 / 12 LEU A  32
LEU A  35
MET A  70
LEU A  77
ARG A  80
 1CA  A 249 (-3.9A)
1CA  A 249 ( 4.4A)
1CA  A 249 ( 3.8A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
 0.27A 5toaA-3ry9A:
25.9		 5toaA-3ry9A:
29.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		10 / 12 LEU A  32
LEU A  35
GLY A  36
GLY A  37
GLN A  39
MET A  73
LEU A  77
ARG A  80
CYH A 112
MET A 115
 1CA  A 249 (-3.9A)
1CA  A 249 ( 4.4A)
1CA  A 249 ( 4.0A)
None
1CA  A 249 (-3.0A)
1CA  A 249 (-3.9A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
None
1CA  A 249 (-3.6A)
 0.73A 5uc1A-3ry9A:
24.4		 5uc1A-3ry9A:
70.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		10 / 12 LEU A  35
GLY A  36
GLY A  37
GLN A  39
TRP A  69
MET A  73
LEU A  77
ARG A  80
CYH A 112
MET A 115
 1CA  A 249 ( 4.4A)
1CA  A 249 ( 4.0A)
None
1CA  A 249 (-3.0A)
None
1CA  A 249 (-3.9A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
None
1CA  A 249 (-3.6A)
 0.92A 5uc1A-3ry9A:
24.4		 5uc1A-3ry9A:
70.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		11 / 12 LEU A  32
ASN A  33
LEU A  35
GLY A  36
GLY A  37
GLN A  39
MET A  73
LEU A  77
ARG A  80
CYH A 112
MET A 115
 1CA  A 249 (-3.9A)
1CA  A 249 (-3.0A)
1CA  A 249 ( 4.4A)
1CA  A 249 ( 4.0A)
None
1CA  A 249 (-3.0A)
1CA  A 249 (-3.9A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
None
1CA  A 249 (-3.6A)
 0.77A 5uc1B-3ry9A:
24.4		 5uc1B-3ry9A:
70.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UC3_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		10 / 12 ASN A  33
GLY A  36
GLN A  39
TRP A  69
MET A  73
ARG A  80
PHE A  92
MET A 115
LEU A 201
CYH A 205
 1CA  A 249 (-3.0A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
None
1CA  A 249 (-3.9A)
1CA  A 249 (-3.5A)
None
1CA  A 249 (-3.6A)
1CA  A 249 ( 4.2A)
1CA  A 249 (-4.0A)
 0.75A 5uc3A-3ry9A:
31.3		 5uc3A-3ry9A:
69.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UC3_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1
(synthetic
construct) 		9 / 12 LEU A  32
GLY A  36
GLN A  39
TRP A  69
ARG A  80
PHE A  92
MET A 115
LEU A 201
CYH A 205
 1CA  A 249 (-3.9A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
None
1CA  A 249 (-3.5A)
None
1CA  A 249 (-3.6A)
1CA  A 249 ( 4.2A)
1CA  A 249 (-4.0A)
 0.72A 5uc3B-3ry9A:
31.0		 5uc3B-3ry9A:
69.23